Highly specific capture and direct MALDI-MS analysis of phosphorylated peptides using novel multifunctional chitosan-GMA-IDA-Fe (III) nanosphere

In this study, we describe a method for highly specific enrichment of phosphopeptides with multifunctional chitosan–glycidyl methacrylate (GMA)–iminodiacetic acid (IDA)–Fe (III) nanospheres for direct analysis by matrix-assisted laser desorption–ionization mass spectrometry (MALDI-MS). This is the f...

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Veröffentlicht in:	Analytical and bioanalytical chemistry 2011-09, Vol.401 (4), p.1251-1261
Hauptverfasser:	Zou, Xiajuan, Liu, Dan, Zhong, Lijun, Yang, Bin, Lou, Yaxin, Hu, Baihe, Yin, Yuxin
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical Chemistry Animals Binding Biochemistry Characterization and Evaluation of Materials Chemistry Chemistry and Materials Science Chitosan Chitosan - chemistry Chromatographic methods and physical methods associated with chromatography Enrichment Exact sciences and technology Food Science Imino Acids - chemistry Ionization Iron - chemistry Laboratory Medicine Metal Nanoparticles - chemistry Methacrylates - chemistry Microscopy, Electron, Scanning Molecular Structure Monitoring/Environmental Analysis Nanocomposites Nanomaterials Nanospheres Nanospheres - chemistry Nanostructure Organic acids Original Paper Other chromatographic methods Peptides Phosphopeptides - chemistry Spectrometric and optical methods Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Titanium dioxide
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