Fluorescence Study of Lipid Bilayer Interactions of Eu(III) Coordination Complexes
The interaction between Eu(III) tris-β-diketonato coordination complexes (EC), displaying antitumor activity, and lipid vesicles composed of zwitterionic lipid phosphatidylcholine has been studied using fluorescence spectroscopy techniques. To characterize EC-membrane binding, several fluorescent pr...
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| Veröffentlicht in: | Journal of fluorescence 2011-07, Vol.21 (4), p.1689-1695 |
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| container_title | Journal of fluorescence |
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| creator | Kutsenko, Olga K. Trusova, Valeriya M. Gorbenko, Galyna P. Deligeorgiev, Todor Vasilev, Aleksey Kaloianova, Stefka Lesev, Nedyalko |
| description | The interaction between Eu(III) tris-β-diketonato coordination complexes (EC), displaying antitumor activity, and lipid vesicles composed of zwitterionic lipid phosphatidylcholine has been studied using fluorescence spectroscopy techniques. To characterize EC-membrane binding, several fluorescent probes, including pyrene, Prodan and 1,6-diphenyl-1,3,5-hexatriene, have been employed. It has been found that EC display effective partitioning into lipid phase, giving rise to structural modifications of both polar and nonpolar lipid bilayer regions, viz. enhancement of membrane hydration and increase in tightness of lipid chain packing. The fact that EC accumulating in lipid bilayer are incapable of inducing significant disruption of membrane structural integrity creates strong prerequisites for development of liposomal nanocarriers of these potential antitumor drugs. Such a possibility is also corroborated by the observation that EC membrane incorporation does not prevent lipid bilayer partitioning of long-wavelength squaraine dyes which represent promising candidates for visualization of liposome biodistribution. |
| doi_str_mv | 10.1007/s10895-011-0861-z |
| format | Article |
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To characterize EC-membrane binding, several fluorescent probes, including pyrene, Prodan and 1,6-diphenyl-1,3,5-hexatriene, have been employed. It has been found that EC display effective partitioning into lipid phase, giving rise to structural modifications of both polar and nonpolar lipid bilayer regions, viz. enhancement of membrane hydration and increase in tightness of lipid chain packing. The fact that EC accumulating in lipid bilayer are incapable of inducing significant disruption of membrane structural integrity creates strong prerequisites for development of liposomal nanocarriers of these potential antitumor drugs. Such a possibility is also corroborated by the observation that EC membrane incorporation does not prevent lipid bilayer partitioning of long-wavelength squaraine dyes which represent promising candidates for visualization of liposome biodistribution.</description><identifier>ISSN: 1053-0509</identifier><identifier>EISSN: 1573-4994</identifier><identifier>DOI: 10.1007/s10895-011-0861-z</identifier><identifier>PMID: 21340618</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Analytical Chemistry ; Binding ; Biochemistry ; Biological and Medical Physics ; Biomedical and Life Sciences ; Biomedicine ; Biophysics ; Biotechnology ; Chains ; Europium - chemistry ; Fluorescence ; Lipid Bilayers - chemistry ; Lipids ; Membranes ; Molecular Structure ; Nanomaterials ; Nanostructure ; Organometallic Compounds - chemical synthesis ; Organometallic Compounds - chemistry ; Original Paper ; Partitioning ; Phosphatidylcholines - chemistry ; Spectrometry, Fluorescence ; Stereoisomerism</subject><ispartof>Journal of fluorescence, 2011-07, Vol.21 (4), p.1689-1695</ispartof><rights>Springer Science+Business Media, LLC 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-93777d07050a99c06cc2c46b35a2e6817c3a0686c870076f5b2d36f511d81eb43</citedby><cites>FETCH-LOGICAL-c375t-93777d07050a99c06cc2c46b35a2e6817c3a0686c870076f5b2d36f511d81eb43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10895-011-0861-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10895-011-0861-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21340618$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kutsenko, Olga K.</creatorcontrib><creatorcontrib>Trusova, Valeriya M.</creatorcontrib><creatorcontrib>Gorbenko, Galyna P.</creatorcontrib><creatorcontrib>Deligeorgiev, Todor</creatorcontrib><creatorcontrib>Vasilev, Aleksey</creatorcontrib><creatorcontrib>Kaloianova, Stefka</creatorcontrib><creatorcontrib>Lesev, Nedyalko</creatorcontrib><title>Fluorescence Study of Lipid Bilayer Interactions of Eu(III) Coordination Complexes</title><title>Journal of fluorescence</title><addtitle>J Fluoresc</addtitle><addtitle>J Fluoresc</addtitle><description>The interaction between Eu(III) tris-β-diketonato coordination complexes (EC), displaying antitumor activity, and lipid vesicles composed of zwitterionic lipid phosphatidylcholine has been studied using fluorescence spectroscopy techniques. To characterize EC-membrane binding, several fluorescent probes, including pyrene, Prodan and 1,6-diphenyl-1,3,5-hexatriene, have been employed. It has been found that EC display effective partitioning into lipid phase, giving rise to structural modifications of both polar and nonpolar lipid bilayer regions, viz. enhancement of membrane hydration and increase in tightness of lipid chain packing. The fact that EC accumulating in lipid bilayer are incapable of inducing significant disruption of membrane structural integrity creates strong prerequisites for development of liposomal nanocarriers of these potential antitumor drugs. Such a possibility is also corroborated by the observation that EC membrane incorporation does not prevent lipid bilayer partitioning of long-wavelength squaraine dyes which represent promising candidates for visualization of liposome biodistribution.</description><subject>Analytical Chemistry</subject><subject>Binding</subject><subject>Biochemistry</subject><subject>Biological and Medical Physics</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Biophysics</subject><subject>Biotechnology</subject><subject>Chains</subject><subject>Europium - chemistry</subject><subject>Fluorescence</subject><subject>Lipid Bilayers - chemistry</subject><subject>Lipids</subject><subject>Membranes</subject><subject>Molecular Structure</subject><subject>Nanomaterials</subject><subject>Nanostructure</subject><subject>Organometallic Compounds - chemical synthesis</subject><subject>Organometallic Compounds - chemistry</subject><subject>Original Paper</subject><subject>Partitioning</subject><subject>Phosphatidylcholines - chemistry</subject><subject>Spectrometry, Fluorescence</subject><subject>Stereoisomerism</subject><issn>1053-0509</issn><issn>1573-4994</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LAzEQhoMoVqs_wIvsTT2sTpLN11FLqwsFwY9zSLOpbNluarILtr_elFaPepoZ3ndeZh6ELjDcYgBxFzFIxXLAOAfJcb45QCeYCZoXShWHqQdGc2CgBug0xgUAKFnIYzQgmBbAsTxBL5Om98FF61rrsteur9aZn2fTelVX2UPdmLULWdl2Lhjb1b6NW3XcX5dleZONvA9V3ZqtkIblqnFfLp6ho7lpojvf1yF6n4zfRk_59PmxHN1Pc0sF63JFhRAViHSfUcoCt5bYgs8oM8RxiYWlBrjkVor0K5-zGaloKhhXErtZQYfoape7Cv6zd7HTyzr90TSmdb6PWhFOScEJ-dcpheJCMc6SE--cNvgYg5vrVaiXJqw1Br1lrnfMdWKut8z1Ju1c7tP72dJVvxs_kJOB7AwxSe2HC3rh-9AmNn-kfgOKNIse</recordid><startdate>20110701</startdate><enddate>20110701</enddate><creator>Kutsenko, Olga K.</creator><creator>Trusova, Valeriya M.</creator><creator>Gorbenko, Galyna P.</creator><creator>Deligeorgiev, Todor</creator><creator>Vasilev, Aleksey</creator><creator>Kaloianova, Stefka</creator><creator>Lesev, Nedyalko</creator><general>Springer US</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope></search><sort><creationdate>20110701</creationdate><title>Fluorescence Study of Lipid Bilayer Interactions of Eu(III) Coordination Complexes</title><author>Kutsenko, Olga K. ; Trusova, Valeriya M. ; Gorbenko, Galyna P. ; Deligeorgiev, Todor ; Vasilev, Aleksey ; Kaloianova, Stefka ; Lesev, Nedyalko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-93777d07050a99c06cc2c46b35a2e6817c3a0686c870076f5b2d36f511d81eb43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Analytical Chemistry</topic><topic>Binding</topic><topic>Biochemistry</topic><topic>Biological and Medical Physics</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Biophysics</topic><topic>Biotechnology</topic><topic>Chains</topic><topic>Europium - chemistry</topic><topic>Fluorescence</topic><topic>Lipid Bilayers - chemistry</topic><topic>Lipids</topic><topic>Membranes</topic><topic>Molecular Structure</topic><topic>Nanomaterials</topic><topic>Nanostructure</topic><topic>Organometallic Compounds - chemical synthesis</topic><topic>Organometallic Compounds - chemistry</topic><topic>Original Paper</topic><topic>Partitioning</topic><topic>Phosphatidylcholines - chemistry</topic><topic>Spectrometry, Fluorescence</topic><topic>Stereoisomerism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kutsenko, Olga K.</creatorcontrib><creatorcontrib>Trusova, Valeriya M.</creatorcontrib><creatorcontrib>Gorbenko, Galyna P.</creatorcontrib><creatorcontrib>Deligeorgiev, Todor</creatorcontrib><creatorcontrib>Vasilev, Aleksey</creatorcontrib><creatorcontrib>Kaloianova, Stefka</creatorcontrib><creatorcontrib>Lesev, Nedyalko</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Journal of fluorescence</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kutsenko, Olga K.</au><au>Trusova, Valeriya M.</au><au>Gorbenko, Galyna P.</au><au>Deligeorgiev, Todor</au><au>Vasilev, Aleksey</au><au>Kaloianova, Stefka</au><au>Lesev, Nedyalko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fluorescence Study of Lipid Bilayer Interactions of Eu(III) Coordination Complexes</atitle><jtitle>Journal of fluorescence</jtitle><stitle>J Fluoresc</stitle><addtitle>J Fluoresc</addtitle><date>2011-07-01</date><risdate>2011</risdate><volume>21</volume><issue>4</issue><spage>1689</spage><epage>1695</epage><pages>1689-1695</pages><issn>1053-0509</issn><eissn>1573-4994</eissn><abstract>The interaction between Eu(III) tris-β-diketonato coordination complexes (EC), displaying antitumor activity, and lipid vesicles composed of zwitterionic lipid phosphatidylcholine has been studied using fluorescence spectroscopy techniques. To characterize EC-membrane binding, several fluorescent probes, including pyrene, Prodan and 1,6-diphenyl-1,3,5-hexatriene, have been employed. It has been found that EC display effective partitioning into lipid phase, giving rise to structural modifications of both polar and nonpolar lipid bilayer regions, viz. enhancement of membrane hydration and increase in tightness of lipid chain packing. The fact that EC accumulating in lipid bilayer are incapable of inducing significant disruption of membrane structural integrity creates strong prerequisites for development of liposomal nanocarriers of these potential antitumor drugs. Such a possibility is also corroborated by the observation that EC membrane incorporation does not prevent lipid bilayer partitioning of long-wavelength squaraine dyes which represent promising candidates for visualization of liposome biodistribution.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>21340618</pmid><doi>10.1007/s10895-011-0861-z</doi><tpages>7</tpages></addata></record> |
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| subjects | Analytical Chemistry Binding Biochemistry Biological and Medical Physics Biomedical and Life Sciences Biomedicine Biophysics Biotechnology Chains Europium - chemistry Fluorescence Lipid Bilayers - chemistry Lipids Membranes Molecular Structure Nanomaterials Nanostructure Organometallic Compounds - chemical synthesis Organometallic Compounds - chemistry Original Paper Partitioning Phosphatidylcholines - chemistry Spectrometry, Fluorescence Stereoisomerism |
| title | Fluorescence Study of Lipid Bilayer Interactions of Eu(III) Coordination Complexes |
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