Validated Spectrofluorimetric Method for the Determination of Lamotrigine in Tablets and Human Plasma Through Derivatization with o-phthalaldehyde

A sensitive, simple and selective spectrofluorimetric method was developed for the determination of Lamotrigine (LMT) in pharmaceutical formulations and biological fluids. The method is based on reaction of LMT with o -phthalaldehyde in presence of 2-mercaptoethanol in borate buffer of pH 9.8 to yie...

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Veröffentlicht in:	Journal of fluorescence 2010-03, Vol.20 (2), p.463-472
Hauptverfasser:	El-Enany, Nahed M., El-Sherbiny, Dina T., Abdelal, Amina A., Belal, Fathalla F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical Chemistry Biochemistry Biological Biological and Medical Physics Biomedical and Life Sciences Biomedicine Biophysics Biotechnology Blood Chemical Analysis - methods Child Derivatives Drugs Epilepsy - blood Epilepsy - drug therapy Fluid flow Fluorescence Human Humans Hydrogen-Ion Concentration Linear Models Male Mercaptoethanol - chemistry Models, Chemical o-Phthalaldehyde - chemistry Original Paper Plasma - chemistry Proposals Reproducibility of Results Sensitivity and Specificity Spectrometry, Fluorescence - methods Tablets Tablets - chemistry Time Factors Triazines - analysis Triazines - chemistry
Online-Zugang:	Volltext
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