Lentiviral Transduction of Face and Limb Flaps: Implications for Immunomodulation of Vascularized Composite Allografts

Ex vivo introduction of an immunomodulatory transgene into a face or hand allograft may improve the risk-to-benefit ratio of vascularized composite allografts. Abrogation of the immunogenicity of the skin component of a face or hand allograft may decrease alloreactivity and permit the induction of i...

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Veröffentlicht in:	Plastic and reconstructive surgery (1963) 2012-02, Vol.129 (2), p.391-400
Hauptverfasser:	Leto Barone, Angelo A., Zhou, Zhao Y., Hughes, Michael W., Park, Ryan, Schulman, Ruth M., Lee, Steven, Vidar, Evan N., Shiba, Travis L., Weber, Erin L., Cetrulo, Curtis L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Extremities - surgery Face - surgery Gene Transfer Techniques Humans Immunomodulation Lentivirus - genetics Medical sciences Rats Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgical Flaps - blood supply Surgical Flaps - immunology Transduction, Genetic
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