Association of Medication with the Human Plasma N-Glycome
Glycosylation is highly variable depending on many environmental factors. Using our fully quantitative high-throughput normal phase hydrophilic interaction liquid chromatography platform we have identified glycosylation changes associated with medication in the plasma N-glycome from three different...
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| Veröffentlicht in: | Journal of proteome research 2012-03, Vol.11 (3), p.1821-1831 |
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| creator | Saldova, Radka Huffman, Jennifer E Adamczyk, Barbara Mužinić, Ana Kattla, Jayesh J Pučić, Maja Novokmet, Mislav Abrahams, Jodie L Hayward, Caroline Rudan, Igor Wild, Sarah H Wright, Alan F Polašek, Ozren Lauc, Gordan Campbell, Harry Wilson, James F Rudd, Pauline M |
| description | Glycosylation is highly variable depending on many environmental factors. Using our fully quantitative high-throughput normal phase hydrophilic interaction liquid chromatography platform we have identified glycosylation changes associated with medication in the plasma N-glycome from three different population cohorts: ORCADES from the Orkney Islands in Scotland and CROATIA-Vis and CROATIA-Korcula from the Croatian islands of Vis and Korcula. Associations between glycosylation and the use of hormones (oral contraceptives, hormone replacement therapy), nonsteroidal anti-inflammatory drugs (aspirin and other NSAIDs), oral steroids (prednisolone) and steroid inhalers (beclomethasone) were investigated. Significant differences associated with usage of oral contraceptives were found with increased core-fucosylated biantennary glycans. Decreases in core-fucosylated biantennary glycans, core-fucosylated triantennary glycans with outer-arm fucose, and high mannosylated glycans were associated with the use of anti-inflammatory drugs. All of the changes in glycosylation were independent of blood group status. In conclusion, hormones and anti-inflammatory medication were associated with changes in glycosylation, possibly as a result of the modulatory effect of these drugs on the inflammatory response. In general, cancer is associated with inflammation, and many glycoproteins in the plasma are acute phase related to the host response. These preliminary data indicate the importance of correcting the levels of glycans used as biomarkers for the effects of medication. |
| doi_str_mv | 10.1021/pr2010605 |
| format | Article |
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Using our fully quantitative high-throughput normal phase hydrophilic interaction liquid chromatography platform we have identified glycosylation changes associated with medication in the plasma N-glycome from three different population cohorts: ORCADES from the Orkney Islands in Scotland and CROATIA-Vis and CROATIA-Korcula from the Croatian islands of Vis and Korcula. Associations between glycosylation and the use of hormones (oral contraceptives, hormone replacement therapy), nonsteroidal anti-inflammatory drugs (aspirin and other NSAIDs), oral steroids (prednisolone) and steroid inhalers (beclomethasone) were investigated. Significant differences associated with usage of oral contraceptives were found with increased core-fucosylated biantennary glycans. Decreases in core-fucosylated biantennary glycans, core-fucosylated triantennary glycans with outer-arm fucose, and high mannosylated glycans were associated with the use of anti-inflammatory drugs. All of the changes in glycosylation were independent of blood group status. In conclusion, hormones and anti-inflammatory medication were associated with changes in glycosylation, possibly as a result of the modulatory effect of these drugs on the inflammatory response. In general, cancer is associated with inflammation, and many glycoproteins in the plasma are acute phase related to the host response. These preliminary data indicate the importance of correcting the levels of glycans used as biomarkers for the effects of medication.</description><identifier>ISSN: 1535-3893</identifier><identifier>EISSN: 1535-3907</identifier><identifier>DOI: 10.1021/pr2010605</identifier><identifier>PMID: 22256781</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>ABO Blood-Group System - blood ; ABO Blood-Group System - chemistry ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Anti-Inflammatory Agents, Non-Steroidal - pharmacology ; Biomarkers - blood ; Case-Control Studies ; Female ; Glycomics ; Glycosylation - drug effects ; Hormones - pharmacology ; Humans ; Male ; Middle Aged ; Polysaccharides - blood ; Polysaccharides - chemistry ; Proteome - metabolism ; Steroids - pharmacology ; Young Adult</subject><ispartof>Journal of proteome research, 2012-03, Vol.11 (3), p.1821-1831</ispartof><rights>Copyright © 2012 American Chemical Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a314t-7fd683d94992843f6371c566b1de738f4c0a66482353fd41b320fe5e82036f603</citedby><cites>FETCH-LOGICAL-a314t-7fd683d94992843f6371c566b1de738f4c0a66482353fd41b320fe5e82036f603</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/pr2010605$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/pr2010605$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2752,27053,27901,27902,56713,56763</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22256781$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Saldova, Radka</creatorcontrib><creatorcontrib>Huffman, Jennifer E</creatorcontrib><creatorcontrib>Adamczyk, Barbara</creatorcontrib><creatorcontrib>Mužinić, Ana</creatorcontrib><creatorcontrib>Kattla, Jayesh J</creatorcontrib><creatorcontrib>Pučić, Maja</creatorcontrib><creatorcontrib>Novokmet, Mislav</creatorcontrib><creatorcontrib>Abrahams, Jodie L</creatorcontrib><creatorcontrib>Hayward, Caroline</creatorcontrib><creatorcontrib>Rudan, Igor</creatorcontrib><creatorcontrib>Wild, Sarah H</creatorcontrib><creatorcontrib>Wright, Alan F</creatorcontrib><creatorcontrib>Polašek, Ozren</creatorcontrib><creatorcontrib>Lauc, Gordan</creatorcontrib><creatorcontrib>Campbell, Harry</creatorcontrib><creatorcontrib>Wilson, James F</creatorcontrib><creatorcontrib>Rudd, Pauline M</creatorcontrib><title>Association of Medication with the Human Plasma N-Glycome</title><title>Journal of proteome research</title><addtitle>J. Proteome Res</addtitle><description>Glycosylation is highly variable depending on many environmental factors. Using our fully quantitative high-throughput normal phase hydrophilic interaction liquid chromatography platform we have identified glycosylation changes associated with medication in the plasma N-glycome from three different population cohorts: ORCADES from the Orkney Islands in Scotland and CROATIA-Vis and CROATIA-Korcula from the Croatian islands of Vis and Korcula. Associations between glycosylation and the use of hormones (oral contraceptives, hormone replacement therapy), nonsteroidal anti-inflammatory drugs (aspirin and other NSAIDs), oral steroids (prednisolone) and steroid inhalers (beclomethasone) were investigated. Significant differences associated with usage of oral contraceptives were found with increased core-fucosylated biantennary glycans. Decreases in core-fucosylated biantennary glycans, core-fucosylated triantennary glycans with outer-arm fucose, and high mannosylated glycans were associated with the use of anti-inflammatory drugs. All of the changes in glycosylation were independent of blood group status. In conclusion, hormones and anti-inflammatory medication were associated with changes in glycosylation, possibly as a result of the modulatory effect of these drugs on the inflammatory response. In general, cancer is associated with inflammation, and many glycoproteins in the plasma are acute phase related to the host response. These preliminary data indicate the importance of correcting the levels of glycans used as biomarkers for the effects of medication.</description><subject>ABO Blood-Group System - blood</subject><subject>ABO Blood-Group System - chemistry</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</subject><subject>Biomarkers - blood</subject><subject>Case-Control Studies</subject><subject>Female</subject><subject>Glycomics</subject><subject>Glycosylation - drug effects</subject><subject>Hormones - pharmacology</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Polysaccharides - blood</subject><subject>Polysaccharides - chemistry</subject><subject>Proteome - metabolism</subject><subject>Steroids - pharmacology</subject><subject>Young Adult</subject><issn>1535-3893</issn><issn>1535-3907</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkM9LwzAUgIMobk4P_gPSi4iHal7SpMlxDN2E-eOg55ClCetom5m0yP57K9128vTeg48P3ofQNeAHwAQet4FgwByzEzQGRllKJc5PD7uQdIQuYtxgDCzH9ByNCCGM5wLGSE5j9KbUbembxLvk1RalGa6fsl0n7domi67WTfJR6Vjr5C2dVzvja3uJzpyuor3azwn6en76nC3S5fv8ZTZdpppC1qa5K7ighcykJCKjjtMcDON8BYXNqXCZwZrzTBDKqCsyWFGCnWVWEEy545hO0N3g3Qb_3dnYqrqMxlaVbqzvopKEAwMJ0JP3A2mCjzFYp7ahrHXYKcDqL5Q6hurZm721W9W2OJKHMj1wOwDaRLXxXWj6J_8R_QI1i2vQ</recordid><startdate>20120302</startdate><enddate>20120302</enddate><creator>Saldova, Radka</creator><creator>Huffman, Jennifer E</creator><creator>Adamczyk, Barbara</creator><creator>Mužinić, Ana</creator><creator>Kattla, Jayesh J</creator><creator>Pučić, Maja</creator><creator>Novokmet, Mislav</creator><creator>Abrahams, Jodie L</creator><creator>Hayward, Caroline</creator><creator>Rudan, Igor</creator><creator>Wild, Sarah H</creator><creator>Wright, Alan F</creator><creator>Polašek, Ozren</creator><creator>Lauc, Gordan</creator><creator>Campbell, Harry</creator><creator>Wilson, James F</creator><creator>Rudd, Pauline M</creator><general>American Chemical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120302</creationdate><title>Association of Medication with the Human Plasma N-Glycome</title><author>Saldova, Radka ; 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Proteome Res</addtitle><date>2012-03-02</date><risdate>2012</risdate><volume>11</volume><issue>3</issue><spage>1821</spage><epage>1831</epage><pages>1821-1831</pages><issn>1535-3893</issn><eissn>1535-3907</eissn><abstract>Glycosylation is highly variable depending on many environmental factors. Using our fully quantitative high-throughput normal phase hydrophilic interaction liquid chromatography platform we have identified glycosylation changes associated with medication in the plasma N-glycome from three different population cohorts: ORCADES from the Orkney Islands in Scotland and CROATIA-Vis and CROATIA-Korcula from the Croatian islands of Vis and Korcula. Associations between glycosylation and the use of hormones (oral contraceptives, hormone replacement therapy), nonsteroidal anti-inflammatory drugs (aspirin and other NSAIDs), oral steroids (prednisolone) and steroid inhalers (beclomethasone) were investigated. Significant differences associated with usage of oral contraceptives were found with increased core-fucosylated biantennary glycans. Decreases in core-fucosylated biantennary glycans, core-fucosylated triantennary glycans with outer-arm fucose, and high mannosylated glycans were associated with the use of anti-inflammatory drugs. All of the changes in glycosylation were independent of blood group status. In conclusion, hormones and anti-inflammatory medication were associated with changes in glycosylation, possibly as a result of the modulatory effect of these drugs on the inflammatory response. In general, cancer is associated with inflammation, and many glycoproteins in the plasma are acute phase related to the host response. These preliminary data indicate the importance of correcting the levels of glycans used as biomarkers for the effects of medication.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>22256781</pmid><doi>10.1021/pr2010605</doi><tpages>11</tpages></addata></record> |
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| ispartof | Journal of proteome research, 2012-03, Vol.11 (3), p.1821-1831 |
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| subjects | ABO Blood-Group System - blood ABO Blood-Group System - chemistry Adolescent Adult Aged Aged, 80 and over Anti-Inflammatory Agents, Non-Steroidal - pharmacology Biomarkers - blood Case-Control Studies Female Glycomics Glycosylation - drug effects Hormones - pharmacology Humans Male Middle Aged Polysaccharides - blood Polysaccharides - chemistry Proteome - metabolism Steroids - pharmacology Young Adult |
| title | Association of Medication with the Human Plasma N-Glycome |
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