Uterine heterologous malignant mixed Müllerian tumor in a dwarf rabbit (Oryctolagus cuniculus)
Malignant mixed Müllerian tumor (MMMT) is a rare neoplasm of the female genital system. A case of MMMT in the uterus of an 8-year-old female dwarf rabbit, which died with clinical signs associated with severe acute dyspnea and anorexia, is described. At necropsy, an oval, firm tumor was found in eac...
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| Veröffentlicht in: | Journal of veterinary diagnostic investigation 2012-03, Vol.24 (2), p.418-422 |
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| creator | Zadravec, Marko Gombac, Mitja Racnik, Jozko Rojs, Olga Zorman Pogacnik, Milan Svara, Tanja |
| description | Malignant mixed Müllerian tumor (MMMT) is a rare neoplasm of the female genital system. A case of MMMT in the uterus of an 8-year-old female dwarf rabbit, which died with clinical signs associated with severe acute dyspnea and anorexia, is described. At necropsy, an oval, firm tumor was found in each of the 2 uterine horns. Numerous metastases were scattered throughout the mediastinum, thoracic diaphragm, and all pulmonary lobes. Microscopically, the tumors consisted of a poorly demarcated, unencapsulated neoplasm, composed of closely associated carcinomatous and sarcomatous components and areas of osteosarcomatous differentiation. Metastases were composed entirely of the sarcomatous component with osteosarcomatous differentiation. Immunohistochemically, the neoplastic epithelial component was positive for cytokeratin and negative for α-smooth muscle actin (α-SMA), vimentin, and desmin. The sarcomatous component was diffusely and strongly positive for vimentin, focally positive for α-SMA ( |
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A case of MMMT in the uterus of an 8-year-old female dwarf rabbit, which died with clinical signs associated with severe acute dyspnea and anorexia, is described. At necropsy, an oval, firm tumor was found in each of the 2 uterine horns. Numerous metastases were scattered throughout the mediastinum, thoracic diaphragm, and all pulmonary lobes. Microscopically, the tumors consisted of a poorly demarcated, unencapsulated neoplasm, composed of closely associated carcinomatous and sarcomatous components and areas of osteosarcomatous differentiation. Metastases were composed entirely of the sarcomatous component with osteosarcomatous differentiation. Immunohistochemically, the neoplastic epithelial component was positive for cytokeratin and negative for α-smooth muscle actin (α-SMA), vimentin, and desmin. The sarcomatous component was diffusely and strongly positive for vimentin, focally positive for α-SMA (<20% of cells positive), and negative for desmin. The neoplasm was diagnosed as a heterologous MMMT with metastases to the lung, mediastinum, and thoracic diaphragm.</description><identifier>ISSN: 1040-6387</identifier><identifier>EISSN: 1943-4936</identifier><identifier>DOI: 10.1177/1040638711433324</identifier><identifier>PMID: 22379058</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>actin ; Animals ; anorexia ; desmin ; diaphragm ; dyspnea ; Fatal Outcome ; Female ; female genitalia ; Immunohistochemistry - veterinary ; mediastinum ; metastasis ; Mixed Tumor, Mullerian - pathology ; Mixed Tumor, Mullerian - veterinary ; necropsy ; neoplasms ; Oryctolagus cuniculus ; Rabbits ; Uterine Neoplasms - pathology ; Uterine Neoplasms - veterinary ; uterus ; vimentin</subject><ispartof>Journal of veterinary diagnostic investigation, 2012-03, Vol.24 (2), p.418-422</ispartof><rights>2012 American Association of Veterinary Laboratory Diagnosticians</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c468t-fc52504d42f0f3f7273289819686d0d0e8f1cc475f2e273fb4217447667ce4713</citedby><cites>FETCH-LOGICAL-c468t-fc52504d42f0f3f7273289819686d0d0e8f1cc475f2e273fb4217447667ce4713</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/1040638711433324$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/1040638711433324$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21819,27924,27925,43621,43622</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22379058$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zadravec, Marko</creatorcontrib><creatorcontrib>Gombac, Mitja</creatorcontrib><creatorcontrib>Racnik, Jozko</creatorcontrib><creatorcontrib>Rojs, Olga Zorman</creatorcontrib><creatorcontrib>Pogacnik, Milan</creatorcontrib><creatorcontrib>Svara, Tanja</creatorcontrib><title>Uterine heterologous malignant mixed Müllerian tumor in a dwarf rabbit (Oryctolagus cuniculus)</title><title>Journal of veterinary diagnostic investigation</title><addtitle>J Vet Diagn Invest</addtitle><description>Malignant mixed Müllerian tumor (MMMT) is a rare neoplasm of the female genital system. A case of MMMT in the uterus of an 8-year-old female dwarf rabbit, which died with clinical signs associated with severe acute dyspnea and anorexia, is described. At necropsy, an oval, firm tumor was found in each of the 2 uterine horns. Numerous metastases were scattered throughout the mediastinum, thoracic diaphragm, and all pulmonary lobes. Microscopically, the tumors consisted of a poorly demarcated, unencapsulated neoplasm, composed of closely associated carcinomatous and sarcomatous components and areas of osteosarcomatous differentiation. Metastases were composed entirely of the sarcomatous component with osteosarcomatous differentiation. Immunohistochemically, the neoplastic epithelial component was positive for cytokeratin and negative for α-smooth muscle actin (α-SMA), vimentin, and desmin. The sarcomatous component was diffusely and strongly positive for vimentin, focally positive for α-SMA (<20% of cells positive), and negative for desmin. The neoplasm was diagnosed as a heterologous MMMT with metastases to the lung, mediastinum, and thoracic diaphragm.</description><subject>actin</subject><subject>Animals</subject><subject>anorexia</subject><subject>desmin</subject><subject>diaphragm</subject><subject>dyspnea</subject><subject>Fatal Outcome</subject><subject>Female</subject><subject>female genitalia</subject><subject>Immunohistochemistry - veterinary</subject><subject>mediastinum</subject><subject>metastasis</subject><subject>Mixed Tumor, Mullerian - pathology</subject><subject>Mixed Tumor, Mullerian - veterinary</subject><subject>necropsy</subject><subject>neoplasms</subject><subject>Oryctolagus cuniculus</subject><subject>Rabbits</subject><subject>Uterine Neoplasms - pathology</subject><subject>Uterine Neoplasms - veterinary</subject><subject>uterus</subject><subject>vimentin</subject><issn>1040-6387</issn><issn>1943-4936</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kD1PxiAUhYnR-L07KZs6VLlASzsa41eicdB3JrwUKoYWhTbqf3Pzj4l51cHB6d7kPOfk3oPQDpAjACGOgXBSsVoAcMYY5UtoHRrOCt6wajnvWS6-9DW0kdIjISUtBayiNUqZaEhZryM5G010g8EPJi_Bhy5MCffKu25Qw4h792pafPPx7n3m1IDHqQ8RuwEr3L6oaHFU87kb8cFtfNNj8KrLfj0NTk9-SodbaMUqn8z299xEs_Oz-9PL4vr24ur05LrQvKrHwup8GuEtp5ZYZgUVjNZNDU1VVy1piaktaM1FaanJmp1zCoJzUVVCGy6AbaL9Re5TDM-TSaPsXdLGezWY_JFsaAUlQFlmkixIHUNK0Vj5FF2v4psEIr9alX9bzZbd7_Bp3pv21_BTYwaKBZBUZ-RjmOKQn_0vcG_BWxWk6qJLcnZHCXBCiBAlp-wTf3yIWg</recordid><startdate>20120301</startdate><enddate>20120301</enddate><creator>Zadravec, Marko</creator><creator>Gombac, Mitja</creator><creator>Racnik, Jozko</creator><creator>Rojs, Olga Zorman</creator><creator>Pogacnik, Milan</creator><creator>Svara, Tanja</creator><general>SAGE Publications</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120301</creationdate><title>Uterine heterologous malignant mixed Müllerian tumor in a dwarf rabbit (Oryctolagus cuniculus)</title><author>Zadravec, Marko ; Gombac, Mitja ; Racnik, Jozko ; Rojs, Olga Zorman ; Pogacnik, Milan ; Svara, Tanja</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c468t-fc52504d42f0f3f7273289819686d0d0e8f1cc475f2e273fb4217447667ce4713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>actin</topic><topic>Animals</topic><topic>anorexia</topic><topic>desmin</topic><topic>diaphragm</topic><topic>dyspnea</topic><topic>Fatal Outcome</topic><topic>Female</topic><topic>female genitalia</topic><topic>Immunohistochemistry - veterinary</topic><topic>mediastinum</topic><topic>metastasis</topic><topic>Mixed Tumor, Mullerian - pathology</topic><topic>Mixed Tumor, Mullerian - veterinary</topic><topic>necropsy</topic><topic>neoplasms</topic><topic>Oryctolagus cuniculus</topic><topic>Rabbits</topic><topic>Uterine Neoplasms - pathology</topic><topic>Uterine Neoplasms - veterinary</topic><topic>uterus</topic><topic>vimentin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zadravec, Marko</creatorcontrib><creatorcontrib>Gombac, Mitja</creatorcontrib><creatorcontrib>Racnik, Jozko</creatorcontrib><creatorcontrib>Rojs, Olga Zorman</creatorcontrib><creatorcontrib>Pogacnik, Milan</creatorcontrib><creatorcontrib>Svara, Tanja</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of veterinary diagnostic investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zadravec, Marko</au><au>Gombac, Mitja</au><au>Racnik, Jozko</au><au>Rojs, Olga Zorman</au><au>Pogacnik, Milan</au><au>Svara, Tanja</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Uterine heterologous malignant mixed Müllerian tumor in a dwarf rabbit (Oryctolagus cuniculus)</atitle><jtitle>Journal of veterinary diagnostic investigation</jtitle><addtitle>J Vet Diagn Invest</addtitle><date>2012-03-01</date><risdate>2012</risdate><volume>24</volume><issue>2</issue><spage>418</spage><epage>422</epage><pages>418-422</pages><issn>1040-6387</issn><eissn>1943-4936</eissn><abstract>Malignant mixed Müllerian tumor (MMMT) is a rare neoplasm of the female genital system. A case of MMMT in the uterus of an 8-year-old female dwarf rabbit, which died with clinical signs associated with severe acute dyspnea and anorexia, is described. At necropsy, an oval, firm tumor was found in each of the 2 uterine horns. Numerous metastases were scattered throughout the mediastinum, thoracic diaphragm, and all pulmonary lobes. Microscopically, the tumors consisted of a poorly demarcated, unencapsulated neoplasm, composed of closely associated carcinomatous and sarcomatous components and areas of osteosarcomatous differentiation. Metastases were composed entirely of the sarcomatous component with osteosarcomatous differentiation. Immunohistochemically, the neoplastic epithelial component was positive for cytokeratin and negative for α-smooth muscle actin (α-SMA), vimentin, and desmin. The sarcomatous component was diffusely and strongly positive for vimentin, focally positive for α-SMA (<20% of cells positive), and negative for desmin. The neoplasm was diagnosed as a heterologous MMMT with metastases to the lung, mediastinum, and thoracic diaphragm.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>22379058</pmid><doi>10.1177/1040638711433324</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | actin Animals anorexia desmin diaphragm dyspnea Fatal Outcome Female female genitalia Immunohistochemistry - veterinary mediastinum metastasis Mixed Tumor, Mullerian - pathology Mixed Tumor, Mullerian - veterinary necropsy neoplasms Oryctolagus cuniculus Rabbits Uterine Neoplasms - pathology Uterine Neoplasms - veterinary uterus vimentin |
| title | Uterine heterologous malignant mixed Müllerian tumor in a dwarf rabbit (Oryctolagus cuniculus) |
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