Regional differences in grey and white matter in children and adults with autism spectrum disorders: an activation likelihood estimate (ALE) meta-analysis
Structural alterations in brain morphology have been inconsistently reported in children compared to adults with autism spectrum disorder (ASD). We assessed these differences by performing meta‐analysis on the data from 19 voxel‐based morphometry studies. Common findings across the age groups were g...
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| Veröffentlicht in: | Autism research 2012-02, Vol.5 (1), p.49-66 |
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| creator | Duerden, Emma G. Mak-Fan, Kathleen M. Taylor, Margot J. Roberts, S. Wendy |
| description | Structural alterations in brain morphology have been inconsistently reported in children compared to adults with autism spectrum disorder (ASD). We assessed these differences by performing meta‐analysis on the data from 19 voxel‐based morphometry studies. Common findings across the age groups were grey matter reduction in left putamen and medial prefrontal cortex (mPFC) and grey matter increases in the lateral PFC, while white matter decreases were seen mainly in the children in frontostriatal pathways. In the ASD sample, children/adolescents were more likely than adults to have increased grey matter in bilateral fusiform gyrus, right cingulate and insula. Results show that clear maturational differences exist in social cognition and limbic processing regions only in children/adolescents and not in adults with ASD, and may underlie the emotional regulation that improves with age in this population. Autism Res 2012,5:49–66. © 2011 International Society for Autism Research, Wiley Periodicals, Inc. |
| doi_str_mv | 10.1002/aur.235 |
| format | Article |
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Results show that clear maturational differences exist in social cognition and limbic processing regions only in children/adolescents and not in adults with ASD, and may underlie the emotional regulation that improves with age in this population. 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Results show that clear maturational differences exist in social cognition and limbic processing regions only in children/adolescents and not in adults with ASD, and may underlie the emotional regulation that improves with age in this population. 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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Adolescent Adult Age Factors Brain - pathology Brain Mapping - methods Child Child Development Disorders, Pervasive - pathology Female Humans Likelihood Functions Magnetic Resonance Imaging - methods Male Nerve Fibers, Myelinated - pathology pediatrics structural MRI |
| title | Regional differences in grey and white matter in children and adults with autism spectrum disorders: an activation likelihood estimate (ALE) meta-analysis |
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