Forskolin Enhances In Vivo Bone Formation by Human Mesenchymal Stromal Cells

Activation of the protein kinase A (PKA) pathway with dibutyryl cyclic adenosine monophosphate (db-cAMP) was recently shown to enhance osteogenic differentiation of human mesenchymal stromal cells (hMSCs) in vitro and bone formation in vivo . The major drawback of this compound is its inhibitory eff...

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Veröffentlicht in:	Tissue engineering. Part A 2012-03, Vol.18 (5-6), p.558-567
Hauptverfasser:	Doorn, Joyce, Siddappa, Ramakrishnaiah, van Blitterswijk, Clemens A., de Boer, Jan
Format:	Artikel
Sprache:	eng
Schlagworte:	8-Bromo Cyclic Adenosine Monophosphate - pharmacology Adenosine Alkaline phosphatase Animals Antigens, Differentiation - biosynthesis Bone Bones Cell culture Cell Differentiation - drug effects Cell Proliferation - drug effects Colforsin - pharmacology Cyclic AMP Cyclic AMP-Dependent Protein Kinases - metabolism Data processing Differentiation Dose-Response Relationship, Drug Enzyme Activation - drug effects Forskolin Humans Insulin-like growth factor I Kinases Mesenchymal Stem Cell Transplantation Mesenchymal Stromal Cells - metabolism Mesenchyme Mice Original Articles Osteogenesis Osteogenesis - drug effects Protein kinase A Proteins Secretion stromal cells Tissue engineering Transplantation, Heterologous
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