A Critical Analysis of the Long-Term Impact of Radical Prostatectomy on Cancer Control and Function Outcomes
Abstract Context The optimal management strategy for men with newly diagnosed clinically localized prostate cancer remains a matter of debate. Numerous series have reported cancer control and quality-of-life (QoL) outcomes following treatment with radical prostatectomy (RP). Objective Critically rev...
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| Veröffentlicht in: | European urology 2012-04, Vol.61 (4), p.664-675 |
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| creator | Boorjian, Stephen A Eastham, James A Graefen, Markus Guillonneau, Bertrand Karnes, R. Jeffrey Moul, Judd W Schaeffer, Edward M Stief, Christian Zorn, Kevin C |
| description | Abstract Context The optimal management strategy for men with newly diagnosed clinically localized prostate cancer remains a matter of debate. Numerous series have reported cancer control and quality-of-life (QoL) outcomes following treatment with radical prostatectomy (RP). Objective Critically review published oncologic and functional outcomes after RP, and evaluate factors associated with these outcome measures. Evidence acquisition A review of the literature was performed using the Medline and Web of Sciences databases. Relevant reports published between 1980 and 2011 identified using the keywords prostate cancer, radical prostatectomy, prostate-specific antigen, biochemical recurrence, incontinence , and erectile dysfunction were reviewed and summarized. Evidence synthesis Cancer control rates following RP largely depend on the definition of treatment efficacy. While up to 40% of men have been reported to experience postoperative biochemical recurrence on long-term follow-up, death from prostate cancer has been noted in |
| doi_str_mv | 10.1016/j.eururo.2011.11.053 |
| format | Article |
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Jeffrey ; Moul, Judd W ; Schaeffer, Edward M ; Stief, Christian ; Zorn, Kevin C</creator><creatorcontrib>Boorjian, Stephen A ; Eastham, James A ; Graefen, Markus ; Guillonneau, Bertrand ; Karnes, R. Jeffrey ; Moul, Judd W ; Schaeffer, Edward M ; Stief, Christian ; Zorn, Kevin C</creatorcontrib><description>Abstract Context The optimal management strategy for men with newly diagnosed clinically localized prostate cancer remains a matter of debate. Numerous series have reported cancer control and quality-of-life (QoL) outcomes following treatment with radical prostatectomy (RP). Objective Critically review published oncologic and functional outcomes after RP, and evaluate factors associated with these outcome measures. Evidence acquisition A review of the literature was performed using the Medline and Web of Sciences databases. Relevant reports published between 1980 and 2011 identified using the keywords prostate cancer, radical prostatectomy, prostate-specific antigen, biochemical recurrence, incontinence , and erectile dysfunction were reviewed and summarized. Evidence synthesis Cancer control rates following RP largely depend on the definition of treatment efficacy. While up to 40% of men have been reported to experience postoperative biochemical recurrence on long-term follow-up, death from prostate cancer has been noted in <10% of men at 15 yr after surgery in contemporary series. For men with high-risk disease, surgery affords pathologic staging, thereby facilitating the selective application of secondary therapies, and has been associated with decreased mortality risk versus radiation in retrospective series. Reported functional outcomes after surgery, particularly urinary continence and erectile dysfunction, have varied greatly to date. These assessments have been limited by nonstandardized reporting methodology. The use of robot-assisted radical prostatectomy has increased in recent years, and while follow-up is thus far short, available data do not suggest the superiority of either approach in terms of functional or oncologic outcomes. Conclusions RP is associated with excellent long-term cancer control. Continued efforts to conduct prospective assessments of postoperative functional outcomes are necessary using validated QoL instruments. The importance of surgical approach will also require further study, incorporating comparative oncologic, functional, and economic data.</description><identifier>ISSN: 0302-2838</identifier><identifier>EISSN: 1873-7560</identifier><identifier>DOI: 10.1016/j.eururo.2011.11.053</identifier><identifier>PMID: 22169079</identifier><identifier>CODEN: EUURAV</identifier><language>eng</language><publisher>Kidlington: Elsevier B.V</publisher><subject>Biochemical recurrence ; Biological and medical sciences ; Erectile dysfunction ; Erectile Dysfunction - etiology ; Evidence-Based Medicine ; Gynecology. Andrology. Obstetrics ; Humans ; Incontinence ; Male ; Male genital diseases ; Medical sciences ; Neoplasm Recurrence, Local ; Nephrology. Urinary tract diseases ; Prostate cancer ; Prostate-specific antigen ; Prostatectomy - adverse effects ; Prostatectomy - mortality ; Prostatic Neoplasms - mortality ; Prostatic Neoplasms - pathology ; Prostatic Neoplasms - surgery ; Quality of Life ; Radical prostatectomy ; Risk Assessment ; Risk Factors ; Time Factors ; Treatment Outcome ; Tumors ; Tumors of the urinary system ; Urinary Incontinence - etiology ; Urinary tract. Prostate gland ; Urology</subject><ispartof>European urology, 2012-04, Vol.61 (4), p.664-675</ispartof><rights>European Association of Urology</rights><rights>2011 European Association of Urology</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 European Association of Urology. Published by Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c512t-a0d52f2c768017c851b6bed9d7d754cad94a0a5957058d96d00ced14b3a6ea1e3</citedby><cites>FETCH-LOGICAL-c512t-a0d52f2c768017c851b6bed9d7d754cad94a0a5957058d96d00ced14b3a6ea1e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0302283811013534$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25631195$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22169079$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Boorjian, Stephen A</creatorcontrib><creatorcontrib>Eastham, James A</creatorcontrib><creatorcontrib>Graefen, Markus</creatorcontrib><creatorcontrib>Guillonneau, Bertrand</creatorcontrib><creatorcontrib>Karnes, R. Jeffrey</creatorcontrib><creatorcontrib>Moul, Judd W</creatorcontrib><creatorcontrib>Schaeffer, Edward M</creatorcontrib><creatorcontrib>Stief, Christian</creatorcontrib><creatorcontrib>Zorn, Kevin C</creatorcontrib><title>A Critical Analysis of the Long-Term Impact of Radical Prostatectomy on Cancer Control and Function Outcomes</title><title>European urology</title><addtitle>Eur Urol</addtitle><description>Abstract Context The optimal management strategy for men with newly diagnosed clinically localized prostate cancer remains a matter of debate. Numerous series have reported cancer control and quality-of-life (QoL) outcomes following treatment with radical prostatectomy (RP). Objective Critically review published oncologic and functional outcomes after RP, and evaluate factors associated with these outcome measures. Evidence acquisition A review of the literature was performed using the Medline and Web of Sciences databases. Relevant reports published between 1980 and 2011 identified using the keywords prostate cancer, radical prostatectomy, prostate-specific antigen, biochemical recurrence, incontinence , and erectile dysfunction were reviewed and summarized. Evidence synthesis Cancer control rates following RP largely depend on the definition of treatment efficacy. While up to 40% of men have been reported to experience postoperative biochemical recurrence on long-term follow-up, death from prostate cancer has been noted in <10% of men at 15 yr after surgery in contemporary series. For men with high-risk disease, surgery affords pathologic staging, thereby facilitating the selective application of secondary therapies, and has been associated with decreased mortality risk versus radiation in retrospective series. Reported functional outcomes after surgery, particularly urinary continence and erectile dysfunction, have varied greatly to date. These assessments have been limited by nonstandardized reporting methodology. The use of robot-assisted radical prostatectomy has increased in recent years, and while follow-up is thus far short, available data do not suggest the superiority of either approach in terms of functional or oncologic outcomes. Conclusions RP is associated with excellent long-term cancer control. Continued efforts to conduct prospective assessments of postoperative functional outcomes are necessary using validated QoL instruments. The importance of surgical approach will also require further study, incorporating comparative oncologic, functional, and economic data.</description><subject>Biochemical recurrence</subject><subject>Biological and medical sciences</subject><subject>Erectile dysfunction</subject><subject>Erectile Dysfunction - etiology</subject><subject>Evidence-Based Medicine</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Incontinence</subject><subject>Male</subject><subject>Male genital diseases</subject><subject>Medical sciences</subject><subject>Neoplasm Recurrence, Local</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Prostate cancer</subject><subject>Prostate-specific antigen</subject><subject>Prostatectomy - adverse effects</subject><subject>Prostatectomy - mortality</subject><subject>Prostatic Neoplasms - mortality</subject><subject>Prostatic Neoplasms - pathology</subject><subject>Prostatic Neoplasms - surgery</subject><subject>Quality of Life</subject><subject>Radical prostatectomy</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>Tumors</subject><subject>Tumors of the urinary system</subject><subject>Urinary Incontinence - etiology</subject><subject>Urinary tract. Prostate gland</subject><subject>Urology</subject><issn>0302-2838</issn><issn>1873-7560</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFklGL1DAQgIMo3nr6D0TyIj51nSRN074IS_H0YOFEz-eQTWY1a9usSSrsvzd1VwVfhEAg-WYm-WYIec5gzYA1rw9rnOMcw5oDY-uyQIoHZMVaJSolG3hIViCAV7wV7RV5ktIBAITsxGNyxTlrOlDdigwb2kefvTUD3UxmOCWfaNjT_BXpNkxfqnuMI70dj8bm5fyjcb_YDzGkbDLaHMYTDRPtzWQx0j5MOYaBmsnRm3my2Ze7uznbMGJ6Sh7tzZDw2WW_Jp9v3t7376vt3bvbfrOtrGQ8Vwac5HtuVdMCU7aVbNfs0HVOOSVra1xXGzCykwpk67rGAVh0rN4J06BhKK7Jq3PeYwzfZ0xZjz5ZHAYzYZiT7rhUTCkmC1mfSVv-kyLu9TH60cSTZqAXzfqgz5r1olmXVTSXsBeXAvNuRPcn6LfXAry8ACYVXftY7Pj0l5ONYKxb6r85c1h0_PAYdbIei0nnY3GrXfD_e8m_Cezgp6VF3_CE6RDmWLqaNNOJa9CflpFYJoKVlEKKWvwE25eyXA</recordid><startdate>20120401</startdate><enddate>20120401</enddate><creator>Boorjian, Stephen A</creator><creator>Eastham, James A</creator><creator>Graefen, Markus</creator><creator>Guillonneau, Bertrand</creator><creator>Karnes, R. Jeffrey</creator><creator>Moul, Judd W</creator><creator>Schaeffer, Edward M</creator><creator>Stief, Christian</creator><creator>Zorn, Kevin C</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120401</creationdate><title>A Critical Analysis of the Long-Term Impact of Radical Prostatectomy on Cancer Control and Function Outcomes</title><author>Boorjian, Stephen A ; Eastham, James A ; Graefen, Markus ; Guillonneau, Bertrand ; Karnes, R. Jeffrey ; Moul, Judd W ; Schaeffer, Edward M ; Stief, Christian ; Zorn, Kevin C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c512t-a0d52f2c768017c851b6bed9d7d754cad94a0a5957058d96d00ced14b3a6ea1e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Biochemical recurrence</topic><topic>Biological and medical sciences</topic><topic>Erectile dysfunction</topic><topic>Erectile Dysfunction - etiology</topic><topic>Evidence-Based Medicine</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Incontinence</topic><topic>Male</topic><topic>Male genital diseases</topic><topic>Medical sciences</topic><topic>Neoplasm Recurrence, Local</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Prostate cancer</topic><topic>Prostate-specific antigen</topic><topic>Prostatectomy - adverse effects</topic><topic>Prostatectomy - mortality</topic><topic>Prostatic Neoplasms - mortality</topic><topic>Prostatic Neoplasms - pathology</topic><topic>Prostatic Neoplasms - surgery</topic><topic>Quality of Life</topic><topic>Radical prostatectomy</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><topic>Tumors</topic><topic>Tumors of the urinary system</topic><topic>Urinary Incontinence - etiology</topic><topic>Urinary tract. Prostate gland</topic><topic>Urology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Boorjian, Stephen A</creatorcontrib><creatorcontrib>Eastham, James A</creatorcontrib><creatorcontrib>Graefen, Markus</creatorcontrib><creatorcontrib>Guillonneau, Bertrand</creatorcontrib><creatorcontrib>Karnes, R. Jeffrey</creatorcontrib><creatorcontrib>Moul, Judd W</creatorcontrib><creatorcontrib>Schaeffer, Edward M</creatorcontrib><creatorcontrib>Stief, Christian</creatorcontrib><creatorcontrib>Zorn, Kevin C</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European urology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Boorjian, Stephen A</au><au>Eastham, James A</au><au>Graefen, Markus</au><au>Guillonneau, Bertrand</au><au>Karnes, R. Jeffrey</au><au>Moul, Judd W</au><au>Schaeffer, Edward M</au><au>Stief, Christian</au><au>Zorn, Kevin C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Critical Analysis of the Long-Term Impact of Radical Prostatectomy on Cancer Control and Function Outcomes</atitle><jtitle>European urology</jtitle><addtitle>Eur Urol</addtitle><date>2012-04-01</date><risdate>2012</risdate><volume>61</volume><issue>4</issue><spage>664</spage><epage>675</epage><pages>664-675</pages><issn>0302-2838</issn><eissn>1873-7560</eissn><coden>EUURAV</coden><abstract>Abstract Context The optimal management strategy for men with newly diagnosed clinically localized prostate cancer remains a matter of debate. Numerous series have reported cancer control and quality-of-life (QoL) outcomes following treatment with radical prostatectomy (RP). Objective Critically review published oncologic and functional outcomes after RP, and evaluate factors associated with these outcome measures. Evidence acquisition A review of the literature was performed using the Medline and Web of Sciences databases. Relevant reports published between 1980 and 2011 identified using the keywords prostate cancer, radical prostatectomy, prostate-specific antigen, biochemical recurrence, incontinence , and erectile dysfunction were reviewed and summarized. Evidence synthesis Cancer control rates following RP largely depend on the definition of treatment efficacy. While up to 40% of men have been reported to experience postoperative biochemical recurrence on long-term follow-up, death from prostate cancer has been noted in <10% of men at 15 yr after surgery in contemporary series. For men with high-risk disease, surgery affords pathologic staging, thereby facilitating the selective application of secondary therapies, and has been associated with decreased mortality risk versus radiation in retrospective series. Reported functional outcomes after surgery, particularly urinary continence and erectile dysfunction, have varied greatly to date. These assessments have been limited by nonstandardized reporting methodology. The use of robot-assisted radical prostatectomy has increased in recent years, and while follow-up is thus far short, available data do not suggest the superiority of either approach in terms of functional or oncologic outcomes. Conclusions RP is associated with excellent long-term cancer control. Continued efforts to conduct prospective assessments of postoperative functional outcomes are necessary using validated QoL instruments. The importance of surgical approach will also require further study, incorporating comparative oncologic, functional, and economic data.</abstract><cop>Kidlington</cop><pub>Elsevier B.V</pub><pmid>22169079</pmid><doi>10.1016/j.eururo.2011.11.053</doi><tpages>12</tpages></addata></record> |
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| subjects | Biochemical recurrence Biological and medical sciences Erectile dysfunction Erectile Dysfunction - etiology Evidence-Based Medicine Gynecology. Andrology. Obstetrics Humans Incontinence Male Male genital diseases Medical sciences Neoplasm Recurrence, Local Nephrology. Urinary tract diseases Prostate cancer Prostate-specific antigen Prostatectomy - adverse effects Prostatectomy - mortality Prostatic Neoplasms - mortality Prostatic Neoplasms - pathology Prostatic Neoplasms - surgery Quality of Life Radical prostatectomy Risk Assessment Risk Factors Time Factors Treatment Outcome Tumors Tumors of the urinary system Urinary Incontinence - etiology Urinary tract. Prostate gland Urology |
| title | A Critical Analysis of the Long-Term Impact of Radical Prostatectomy on Cancer Control and Function Outcomes |
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