Concentrated Dispersions of Equilibrium Protein Nanoclusters That Reversibly Dissociate into Active Monomers

Stabilizing proteins at high concentration is of broad interest in drug delivery, for treatment of cancer and many other diseases. Herein, we create highly concentrated antibody dispersions (up to 260 mg/mL) comprising dense equilibrium nanoclusters of protein (monoclonal antibody 1B7, polyclonal sh...

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Veröffentlicht in:	ACS nano 2012-02, Vol.6 (2), p.1357-1369
Hauptverfasser:	Johnston, Keith P, Maynard, Jennifer A, Truskett, Thomas M, Borwankar, Ameya U, Miller, Maria A, Wilson, Brian K, Dinin, Aileen K, Khan, Tarik A, Kaczorowski, Kevin J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Biocompatibility Buffers Cattle Clusters Colloids Dispersions Drug Carriers - chemistry Drug Carriers - pharmacokinetics Mathematical models Mice Models, Molecular Monomers Nanostructure Nanostructures - chemistry Protein Conformation Protein Stability Proteins Proteins - chemistry Trehalose - chemistry
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