Production of 3-hydroxypropionic acid via malonyl-CoA pathway using recombinant Escherichia coli strains

Malonyl-CoA is an intermediary compound that is produced during fatty acid metabolism. Our study aimed to produce the commercially important platform chemical 3-hydroxypropionic acid (3-HP) from its immediate precursor malonyl-CoA by recombinant Escherichia coli strains heterologously expressing the...

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Veröffentlicht in:	Journal of biotechnology 2012-02, Vol.157 (4), p.633-640
Hauptverfasser:	Rathnasingh, Chelladurai, Raj, Subramanian Mohan, Lee, Youjin, Catherine, Christy, Ashok, Somasundar, Park, Sunghoon
Format:	Artikel
Sprache:	eng
Schlagworte:	3-hydroxypropionic acid Acetyl-CoA carboxylase Acetyl-CoA Carboxylase - metabolism Aerobiosis Anaerobiosis Chloroflexus aurantiacus Escherichia coli - cytology Escherichia coli - enzymology Escherichia coli - genetics Escherichia coli - growth & development Gene Deletion Glucose - metabolism Lactic Acid - analogs & derivatives Lactic Acid - biosynthesis Malonyl Coenzyme A - metabolism Malonyl-CoA Malonyl-CoA reductase Metabolic Networks and Pathways NADP Transhydrogenases - metabolism Oxidoreductases - metabolism Plasmids - genetics Recombination, Genetic - genetics Temperature Time Factors Transhydrogenase
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