Blood platelet biochemistry
Abstract Defects in platelet function or formation increase the risk for bleeding or thrombosis, which indicates the crucial role for platelets in maintaining haemostasis in normal life. Upon vascular injury, platelets instantly adhere to the exposed extracellular matrix which results in platelet ac...
Gespeichert in:
| Veröffentlicht in: | Thrombosis research 2012-03, Vol.129 (3), p.245-249 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 249 |
|---|---|
| container_issue | 3 |
| container_start_page | 245 |
| container_title | Thrombosis research |
| container_volume | 129 |
| creator | Broos, Katleen De Meyer, Simon F Feys, Hendrik B Vanhoorelbeke, Karen Deckmyn, Hans |
| description | Abstract Defects in platelet function or formation increase the risk for bleeding or thrombosis, which indicates the crucial role for platelets in maintaining haemostasis in normal life. Upon vascular injury, platelets instantly adhere to the exposed extracellular matrix which results in platelet activation and aggregation and the formation a haemostatic plug that stops bleeding. To prevent excessive platelet aggregate formation that eventually would occlude the vessels, this self-amplifying process nevertheless requires a tight control. This review intends to give a comprehensive overview of the currently established main mechanisms in platelet function. |
| doi_str_mv | 10.1016/j.thromres.2011.11.002 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_924961813</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0049384811005780</els_id><sourcerecordid>924961813</sourcerecordid><originalsourceid>FETCH-LOGICAL-c452t-db544230349842a4e7aa9b7b65652df83649376592990c42a3117a796efb19a83</originalsourceid><addsrcrecordid>eNqFkU1LHEEQhhsx6Kr5BQHxEjzNpqs_pqcuIYloEhA8aM5NT08N9mZ2eu2eDey_t5ddFXIRCuryVL3FU4ydA58Dh_rLYj49prhMlOeCA8xLcS4O2Awag5VQRhyyGecKK9mo5pid5LzgHAygPmLHQgCgQpyxTz-GGLuL1eAmGmi6aEP0j7QMeUqbM_ahd0Omj_t-yv7cXD9c_apu737-vvp-W3mlxVR1rVZKSC4VNko4RcY5bE1b61qLrm9krVCaWqNA5L4QEsA4gzX1LaBr5Cm73O1dpfi0pjzZku9pGNxIcZ0tCoU1NCALWe9In2LOiXq7SmHp0sYCt1svdmFfvNitF1uqeCmD5_uIdbuk7nXsRUQBPu8Bl70b-uRGH_Ibpw1qIXXhvu04KkL-BUo2-0Cjpy4k8pPtYnj_lq__rfBDGENJ_Usbyou4TmPRbcFmYbm9335x-0QAzrVpuHwG5gKWeg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>924961813</pqid></control><display><type>article</type><title>Blood platelet biochemistry</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Broos, Katleen ; De Meyer, Simon F ; Feys, Hendrik B ; Vanhoorelbeke, Karen ; Deckmyn, Hans</creator><creatorcontrib>Broos, Katleen ; De Meyer, Simon F ; Feys, Hendrik B ; Vanhoorelbeke, Karen ; Deckmyn, Hans</creatorcontrib><description>Abstract Defects in platelet function or formation increase the risk for bleeding or thrombosis, which indicates the crucial role for platelets in maintaining haemostasis in normal life. Upon vascular injury, platelets instantly adhere to the exposed extracellular matrix which results in platelet activation and aggregation and the formation a haemostatic plug that stops bleeding. To prevent excessive platelet aggregate formation that eventually would occlude the vessels, this self-amplifying process nevertheless requires a tight control. This review intends to give a comprehensive overview of the currently established main mechanisms in platelet function.</description><identifier>ISSN: 0049-3848</identifier><identifier>EISSN: 1879-2472</identifier><identifier>DOI: 10.1016/j.thromres.2011.11.002</identifier><identifier>PMID: 22119499</identifier><identifier>CODEN: THBRAA</identifier><language>eng</language><publisher>Amsterdam: Elsevier Ltd</publisher><subject>activation ; aggregation ; Animals ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood coagulation. Blood cells ; Blood Platelets - metabolism ; Cardiology. Vascular system ; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous ; Fundamental and applied biological sciences. Psychology ; Hematology, Oncology and Palliative Medicine ; Hemostasis ; Humans ; Integrin alpha2beta1 - blood ; Medical sciences ; Membrane Glycoproteins - blood ; Molecular and cellular biology ; Platelet ; Platelet Activation ; Platelet adhesion ; Platelet Adhesiveness ; Platelet Aggregation ; Platelet Glycoprotein GPIb-IX Complex ; Platelet Membrane Glycoproteins - metabolism ; secretion ; Signal Transduction ; Thrombosis - blood ; Thrombosis - prevention & control ; von Willebrand Factor - metabolism</subject><ispartof>Thrombosis research, 2012-03, Vol.129 (3), p.245-249</ispartof><rights>Elsevier Ltd</rights><rights>2011 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c452t-db544230349842a4e7aa9b7b65652df83649376592990c42a3117a796efb19a83</citedby><cites>FETCH-LOGICAL-c452t-db544230349842a4e7aa9b7b65652df83649376592990c42a3117a796efb19a83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.thromres.2011.11.002$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,776,780,785,786,3536,23910,23911,25119,27903,27904,45974</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25795235$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22119499$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Broos, Katleen</creatorcontrib><creatorcontrib>De Meyer, Simon F</creatorcontrib><creatorcontrib>Feys, Hendrik B</creatorcontrib><creatorcontrib>Vanhoorelbeke, Karen</creatorcontrib><creatorcontrib>Deckmyn, Hans</creatorcontrib><title>Blood platelet biochemistry</title><title>Thrombosis research</title><addtitle>Thromb Res</addtitle><description>Abstract Defects in platelet function or formation increase the risk for bleeding or thrombosis, which indicates the crucial role for platelets in maintaining haemostasis in normal life. Upon vascular injury, platelets instantly adhere to the exposed extracellular matrix which results in platelet activation and aggregation and the formation a haemostatic plug that stops bleeding. To prevent excessive platelet aggregate formation that eventually would occlude the vessels, this self-amplifying process nevertheless requires a tight control. This review intends to give a comprehensive overview of the currently established main mechanisms in platelet function.</description><subject>activation</subject><subject>aggregation</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Blood coagulation. Blood cells</subject><subject>Blood Platelets - metabolism</subject><subject>Cardiology. Vascular system</subject><subject>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Hemostasis</subject><subject>Humans</subject><subject>Integrin alpha2beta1 - blood</subject><subject>Medical sciences</subject><subject>Membrane Glycoproteins - blood</subject><subject>Molecular and cellular biology</subject><subject>Platelet</subject><subject>Platelet Activation</subject><subject>Platelet adhesion</subject><subject>Platelet Adhesiveness</subject><subject>Platelet Aggregation</subject><subject>Platelet Glycoprotein GPIb-IX Complex</subject><subject>Platelet Membrane Glycoproteins - metabolism</subject><subject>secretion</subject><subject>Signal Transduction</subject><subject>Thrombosis - blood</subject><subject>Thrombosis - prevention & control</subject><subject>von Willebrand Factor - metabolism</subject><issn>0049-3848</issn><issn>1879-2472</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1LHEEQhhsx6Kr5BQHxEjzNpqs_pqcuIYloEhA8aM5NT08N9mZ2eu2eDey_t5ddFXIRCuryVL3FU4ydA58Dh_rLYj49prhMlOeCA8xLcS4O2Awag5VQRhyyGecKK9mo5pid5LzgHAygPmLHQgCgQpyxTz-GGLuL1eAmGmi6aEP0j7QMeUqbM_ahd0Omj_t-yv7cXD9c_apu737-vvp-W3mlxVR1rVZKSC4VNko4RcY5bE1b61qLrm9krVCaWqNA5L4QEsA4gzX1LaBr5Cm73O1dpfi0pjzZku9pGNxIcZ0tCoU1NCALWe9In2LOiXq7SmHp0sYCt1svdmFfvNitF1uqeCmD5_uIdbuk7nXsRUQBPu8Bl70b-uRGH_Ibpw1qIXXhvu04KkL-BUo2-0Cjpy4k8pPtYnj_lq__rfBDGENJ_Usbyou4TmPRbcFmYbm9335x-0QAzrVpuHwG5gKWeg</recordid><startdate>20120301</startdate><enddate>20120301</enddate><creator>Broos, Katleen</creator><creator>De Meyer, Simon F</creator><creator>Feys, Hendrik B</creator><creator>Vanhoorelbeke, Karen</creator><creator>Deckmyn, Hans</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120301</creationdate><title>Blood platelet biochemistry</title><author>Broos, Katleen ; De Meyer, Simon F ; Feys, Hendrik B ; Vanhoorelbeke, Karen ; Deckmyn, Hans</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-db544230349842a4e7aa9b7b65652df83649376592990c42a3117a796efb19a83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>activation</topic><topic>aggregation</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Blood coagulation. Blood cells</topic><topic>Blood Platelets - metabolism</topic><topic>Cardiology. Vascular system</topic><topic>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Hemostasis</topic><topic>Humans</topic><topic>Integrin alpha2beta1 - blood</topic><topic>Medical sciences</topic><topic>Membrane Glycoproteins - blood</topic><topic>Molecular and cellular biology</topic><topic>Platelet</topic><topic>Platelet Activation</topic><topic>Platelet adhesion</topic><topic>Platelet Adhesiveness</topic><topic>Platelet Aggregation</topic><topic>Platelet Glycoprotein GPIb-IX Complex</topic><topic>Platelet Membrane Glycoproteins - metabolism</topic><topic>secretion</topic><topic>Signal Transduction</topic><topic>Thrombosis - blood</topic><topic>Thrombosis - prevention & control</topic><topic>von Willebrand Factor - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Broos, Katleen</creatorcontrib><creatorcontrib>De Meyer, Simon F</creatorcontrib><creatorcontrib>Feys, Hendrik B</creatorcontrib><creatorcontrib>Vanhoorelbeke, Karen</creatorcontrib><creatorcontrib>Deckmyn, Hans</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Thrombosis research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Broos, Katleen</au><au>De Meyer, Simon F</au><au>Feys, Hendrik B</au><au>Vanhoorelbeke, Karen</au><au>Deckmyn, Hans</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Blood platelet biochemistry</atitle><jtitle>Thrombosis research</jtitle><addtitle>Thromb Res</addtitle><date>2012-03-01</date><risdate>2012</risdate><volume>129</volume><issue>3</issue><spage>245</spage><epage>249</epage><pages>245-249</pages><issn>0049-3848</issn><eissn>1879-2472</eissn><coden>THBRAA</coden><abstract>Abstract Defects in platelet function or formation increase the risk for bleeding or thrombosis, which indicates the crucial role for platelets in maintaining haemostasis in normal life. Upon vascular injury, platelets instantly adhere to the exposed extracellular matrix which results in platelet activation and aggregation and the formation a haemostatic plug that stops bleeding. To prevent excessive platelet aggregate formation that eventually would occlude the vessels, this self-amplifying process nevertheless requires a tight control. This review intends to give a comprehensive overview of the currently established main mechanisms in platelet function.</abstract><cop>Amsterdam</cop><pub>Elsevier Ltd</pub><pmid>22119499</pmid><doi>10.1016/j.thromres.2011.11.002</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0049-3848 |
| ispartof | Thrombosis research, 2012-03, Vol.129 (3), p.245-249 |
| issn | 0049-3848 1879-2472 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_924961813 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | activation aggregation Animals Biological and medical sciences Blood and lymphatic vessels Blood coagulation. Blood cells Blood Platelets - metabolism Cardiology. Vascular system Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Fundamental and applied biological sciences. Psychology Hematology, Oncology and Palliative Medicine Hemostasis Humans Integrin alpha2beta1 - blood Medical sciences Membrane Glycoproteins - blood Molecular and cellular biology Platelet Platelet Activation Platelet adhesion Platelet Adhesiveness Platelet Aggregation Platelet Glycoprotein GPIb-IX Complex Platelet Membrane Glycoproteins - metabolism secretion Signal Transduction Thrombosis - blood Thrombosis - prevention & control von Willebrand Factor - metabolism |
| title | Blood platelet biochemistry |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-23T00%3A52%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Blood%20platelet%20biochemistry&rft.jtitle=Thrombosis%20research&rft.au=Broos,%20Katleen&rft.date=2012-03-01&rft.volume=129&rft.issue=3&rft.spage=245&rft.epage=249&rft.pages=245-249&rft.issn=0049-3848&rft.eissn=1879-2472&rft.coden=THBRAA&rft_id=info:doi/10.1016/j.thromres.2011.11.002&rft_dat=%3Cproquest_cross%3E924961813%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=924961813&rft_id=info:pmid/22119499&rft_els_id=S0049384811005780&rfr_iscdi=true |