miR-200bc/429 cluster modulates multidrug resistance of human cancer cell lines by targeting BCL2 and XIAP

Purpose MicroRNAs (miRNAs) are short non-coding RNA molecules, which post-transcriptionally regulate genes expression and play crucial roles in diverse biological processes. Recent studies have shown that dysregulation of miRNAs might modulate the resistance of cancer cells to anti-cancer drugs, yet...

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Veröffentlicht in:	Cancer chemotherapy and pharmacology 2012-03, Vol.69 (3), p.723-731
Hauptverfasser:	Zhu, Wei, Xu, Huaguo, Zhu, DanXia, Zhi, Hui, Wang, Tongshan, Wang, Jian, Jiang, Binghua, Shu, Yongqian, Liu, Ping
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Antineoplastic Agents - pharmacology Apoptosis - drug effects Apoptosis - genetics Biological and medical sciences Blotting, Western Cancer Research Cell Line, Tumor Drug Resistance, Multiple - genetics Drug Resistance, Neoplasm - genetics Humans Medical sciences Medicine Medicine & Public Health MicroRNAs - genetics MicroRNAs - physiology Multigene Family Oncology Original Article Pharmacology. Drug treatments Pharmacology/Toxicology Proto-Oncogene Proteins c-bcl-2 - genetics Real-Time Polymerase Chain Reaction Transfection X-Linked Inhibitor of Apoptosis Protein - genetics
Online-Zugang:	Volltext
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