Halo naevi and leukotrichia are strong predictors of the passage to mixed vitiligo in a subgroup of segmental vitiligo
Summary Background Until now, segmental vitiligo has been considered as a stable entity and mixed vitiligo, the association of segmental and nonsegmental vitiligo, has been reported rarely. Objectives The aim of this study was to search for factors associated with the generalization of vitiligo in...
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| Veröffentlicht in: | British journal of dermatology (1951) 2012-03, Vol.166 (3), p.539-544 |
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| container_title | British journal of dermatology (1951) |
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| creator | Ezzedine, K. Diallo, A. Léauté-Labrèze, C. Séneschal, J. Prey, S. Ballanger, F. Alghamdi, K. Cario-André, M. Jouary, T. Gauthier, Y. Taieb, A. |
| description | Summary
Background Until now, segmental vitiligo has been considered as a stable entity and mixed vitiligo, the association of segmental and nonsegmental vitiligo, has been reported rarely.
Objectives The aim of this study was to search for factors associated with the generalization of vitiligo in patients with segmental vitiligo.
Patients and methods This was a prospective observational study conducted in the vitiligo clinic of the Department of Dermatology of Bordeaux, France. The Vitiligo European Task Force questionnaire was completed for each patient attending the clinic with a confirmed diagnosis of segmental vitiligo after exclusion of other forms of vitiligo (focal, mucosal, not classifiable.) Thyroid function and antithyroid antibodies were screened if not obtained in the previous year.
Results One hundred and twenty‐seven patients were recruited: 101 had segmental vitiligo and 26 had segmental vitiligo that evolved into mixed vitiligo; 56 were male and 71 were female. Most patients had onset of segmental vitiligo before the age of 18. When conducting multivariate analysis, we found the following to be independent factors associated with the evolution of patients’ disease from segmental vitiligo to mixed vitiligo: initial percentage of body surface involvement of the segment > 1% [odds ratio (OR) 15·14, P = 0·002], the presence of halo naevi (OR 24·82, P = 0·0001) and leukotrichia (OR 25·73, P = 0·0009).
Conclusions Halo naevi association and leukotrichia at first consultation in segmental vitiligo are risk factors for the progression of segmental vitiligo to mixed vitiligo. In addition, this progression of segmental vitiligo to mixed vitiligo carries a stronger link if initial segmental involvement is situated on the trunk.
See also the Commentary by Picardo |
| doi_str_mv | 10.1111/j.1365-2133.2011.10709.x |
| format | Article |
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Background Until now, segmental vitiligo has been considered as a stable entity and mixed vitiligo, the association of segmental and nonsegmental vitiligo, has been reported rarely.
Objectives The aim of this study was to search for factors associated with the generalization of vitiligo in patients with segmental vitiligo.
Patients and methods This was a prospective observational study conducted in the vitiligo clinic of the Department of Dermatology of Bordeaux, France. The Vitiligo European Task Force questionnaire was completed for each patient attending the clinic with a confirmed diagnosis of segmental vitiligo after exclusion of other forms of vitiligo (focal, mucosal, not classifiable.) Thyroid function and antithyroid antibodies were screened if not obtained in the previous year.
Results One hundred and twenty‐seven patients were recruited: 101 had segmental vitiligo and 26 had segmental vitiligo that evolved into mixed vitiligo; 56 were male and 71 were female. Most patients had onset of segmental vitiligo before the age of 18. When conducting multivariate analysis, we found the following to be independent factors associated with the evolution of patients’ disease from segmental vitiligo to mixed vitiligo: initial percentage of body surface involvement of the segment > 1% [odds ratio (OR) 15·14, P = 0·002], the presence of halo naevi (OR 24·82, P = 0·0001) and leukotrichia (OR 25·73, P = 0·0009).
Conclusions Halo naevi association and leukotrichia at first consultation in segmental vitiligo are risk factors for the progression of segmental vitiligo to mixed vitiligo. In addition, this progression of segmental vitiligo to mixed vitiligo carries a stronger link if initial segmental involvement is situated on the trunk.
See also the Commentary by Picardo</description><identifier>ISSN: 0007-0963</identifier><identifier>EISSN: 1365-2133</identifier><identifier>DOI: 10.1111/j.1365-2133.2011.10709.x</identifier><identifier>PMID: 22032627</identifier><identifier>CODEN: BJDEAZ</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; Age of Onset ; Biological and medical sciences ; Child ; Child, Preschool ; Dermatology ; Disease Progression ; Female ; Hair Color ; Hair Diseases - complications ; Humans ; Infant ; Male ; Medical sciences ; Multivariate Analysis ; Nevus, Halo - complications ; Pigmentary diseases of the skin ; Prospective Studies ; Risk Factors ; Tumors of the skin and soft tissue. Premalignant lesions ; Vitiligo - etiology ; Young Adult</subject><ispartof>British journal of dermatology (1951), 2012-03, Vol.166 (3), p.539-544</ispartof><rights>2011 The Authors. BJD © 2011 British Association of Dermatologists</rights><rights>2015 INIST-CNRS</rights><rights>2011 The Authors. BJD © 2011 British Association of Dermatologists.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4549-7ea8500c784d2bba33c2ec04cac6903b19641a42c9323c1ebcd286ff8244f6053</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2133.2011.10709.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2133.2011.10709.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27929,27930,45579,45580</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25631805$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22032627$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ezzedine, K.</creatorcontrib><creatorcontrib>Diallo, A.</creatorcontrib><creatorcontrib>Léauté-Labrèze, C.</creatorcontrib><creatorcontrib>Séneschal, J.</creatorcontrib><creatorcontrib>Prey, S.</creatorcontrib><creatorcontrib>Ballanger, F.</creatorcontrib><creatorcontrib>Alghamdi, K.</creatorcontrib><creatorcontrib>Cario-André, M.</creatorcontrib><creatorcontrib>Jouary, T.</creatorcontrib><creatorcontrib>Gauthier, Y.</creatorcontrib><creatorcontrib>Taieb, A.</creatorcontrib><title>Halo naevi and leukotrichia are strong predictors of the passage to mixed vitiligo in a subgroup of segmental vitiligo</title><title>British journal of dermatology (1951)</title><addtitle>Br J Dermatol</addtitle><description>Summary
Background Until now, segmental vitiligo has been considered as a stable entity and mixed vitiligo, the association of segmental and nonsegmental vitiligo, has been reported rarely.
Objectives The aim of this study was to search for factors associated with the generalization of vitiligo in patients with segmental vitiligo.
Patients and methods This was a prospective observational study conducted in the vitiligo clinic of the Department of Dermatology of Bordeaux, France. The Vitiligo European Task Force questionnaire was completed for each patient attending the clinic with a confirmed diagnosis of segmental vitiligo after exclusion of other forms of vitiligo (focal, mucosal, not classifiable.) Thyroid function and antithyroid antibodies were screened if not obtained in the previous year.
Results One hundred and twenty‐seven patients were recruited: 101 had segmental vitiligo and 26 had segmental vitiligo that evolved into mixed vitiligo; 56 were male and 71 were female. Most patients had onset of segmental vitiligo before the age of 18. When conducting multivariate analysis, we found the following to be independent factors associated with the evolution of patients’ disease from segmental vitiligo to mixed vitiligo: initial percentage of body surface involvement of the segment > 1% [odds ratio (OR) 15·14, P = 0·002], the presence of halo naevi (OR 24·82, P = 0·0001) and leukotrichia (OR 25·73, P = 0·0009).
Conclusions Halo naevi association and leukotrichia at first consultation in segmental vitiligo are risk factors for the progression of segmental vitiligo to mixed vitiligo. In addition, this progression of segmental vitiligo to mixed vitiligo carries a stronger link if initial segmental involvement is situated on the trunk.
See also the Commentary by Picardo</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age of Onset</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Dermatology</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Hair Color</subject><subject>Hair Diseases - complications</subject><subject>Humans</subject><subject>Infant</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Multivariate Analysis</subject><subject>Nevus, Halo - complications</subject><subject>Pigmentary diseases of the skin</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><subject>Tumors of the skin and soft tissue. Premalignant lesions</subject><subject>Vitiligo - etiology</subject><subject>Young Adult</subject><issn>0007-0963</issn><issn>1365-2133</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkcFu1DAQhi0EokvLKyBfEKeEsZ04yQUJtrQFVUVIrdqbNXGc1NskTu1k2b49m91lmcuMNJ_-keYjhDKI2bY-r2ImZBpxJkTMgbGYQQZFvHlFFsfFa7IAgCyCQooT8i6EFQATkMJbcsI5CC55tiDrK2wd7dGsLcW-oq2ZntzorX60SNEbGkbv-oYO3lRWj84H6mo6Pho6YAjYGDo62tmNqejajra1jaO2p0jDVDbeTcOMB9N0ph-xPTJn5E2NbTDvD_2U3F18v11eRde_Ln8sv15HOkmTIsoM5imAzvKk4mWJQmhuNCQatSxAlKyQCcOE60JwoZkpdcVzWdc5T5JaQipOyad97uDd82TCqDobtGlb7I2bgiq4SHOQrNiSHw7kVHamUoO3HfoX9e9VW-DjAcCgsa099tqG_1wqBct3J7_suT-2NS_HPQM1q1MrNRtSsyE1q1M7dWqjvv08343bgGgfYMNoNscA9E9KZiJL1f3Npfp9wW_OH7J7tRR_AUgSnC8</recordid><startdate>201203</startdate><enddate>201203</enddate><creator>Ezzedine, K.</creator><creator>Diallo, A.</creator><creator>Léauté-Labrèze, C.</creator><creator>Séneschal, J.</creator><creator>Prey, S.</creator><creator>Ballanger, F.</creator><creator>Alghamdi, K.</creator><creator>Cario-André, M.</creator><creator>Jouary, T.</creator><creator>Gauthier, Y.</creator><creator>Taieb, A.</creator><general>Blackwell Publishing Ltd</general><general>Wiley-Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201203</creationdate><title>Halo naevi and leukotrichia are strong predictors of the passage to mixed vitiligo in a subgroup of segmental vitiligo</title><author>Ezzedine, K. ; Diallo, A. ; Léauté-Labrèze, C. ; Séneschal, J. ; Prey, S. ; Ballanger, F. ; Alghamdi, K. ; Cario-André, M. ; Jouary, T. ; Gauthier, Y. ; Taieb, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4549-7ea8500c784d2bba33c2ec04cac6903b19641a42c9323c1ebcd286ff8244f6053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age of Onset</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Dermatology</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Hair Color</topic><topic>Hair Diseases - complications</topic><topic>Humans</topic><topic>Infant</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Multivariate Analysis</topic><topic>Nevus, Halo - complications</topic><topic>Pigmentary diseases of the skin</topic><topic>Prospective Studies</topic><topic>Risk Factors</topic><topic>Tumors of the skin and soft tissue. Premalignant lesions</topic><topic>Vitiligo - etiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ezzedine, K.</creatorcontrib><creatorcontrib>Diallo, A.</creatorcontrib><creatorcontrib>Léauté-Labrèze, C.</creatorcontrib><creatorcontrib>Séneschal, J.</creatorcontrib><creatorcontrib>Prey, S.</creatorcontrib><creatorcontrib>Ballanger, F.</creatorcontrib><creatorcontrib>Alghamdi, K.</creatorcontrib><creatorcontrib>Cario-André, M.</creatorcontrib><creatorcontrib>Jouary, T.</creatorcontrib><creatorcontrib>Gauthier, Y.</creatorcontrib><creatorcontrib>Taieb, A.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of dermatology (1951)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ezzedine, K.</au><au>Diallo, A.</au><au>Léauté-Labrèze, C.</au><au>Séneschal, J.</au><au>Prey, S.</au><au>Ballanger, F.</au><au>Alghamdi, K.</au><au>Cario-André, M.</au><au>Jouary, T.</au><au>Gauthier, Y.</au><au>Taieb, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Halo naevi and leukotrichia are strong predictors of the passage to mixed vitiligo in a subgroup of segmental vitiligo</atitle><jtitle>British journal of dermatology (1951)</jtitle><addtitle>Br J Dermatol</addtitle><date>2012-03</date><risdate>2012</risdate><volume>166</volume><issue>3</issue><spage>539</spage><epage>544</epage><pages>539-544</pages><issn>0007-0963</issn><eissn>1365-2133</eissn><coden>BJDEAZ</coden><abstract>Summary
Background Until now, segmental vitiligo has been considered as a stable entity and mixed vitiligo, the association of segmental and nonsegmental vitiligo, has been reported rarely.
Objectives The aim of this study was to search for factors associated with the generalization of vitiligo in patients with segmental vitiligo.
Patients and methods This was a prospective observational study conducted in the vitiligo clinic of the Department of Dermatology of Bordeaux, France. The Vitiligo European Task Force questionnaire was completed for each patient attending the clinic with a confirmed diagnosis of segmental vitiligo after exclusion of other forms of vitiligo (focal, mucosal, not classifiable.) Thyroid function and antithyroid antibodies were screened if not obtained in the previous year.
Results One hundred and twenty‐seven patients were recruited: 101 had segmental vitiligo and 26 had segmental vitiligo that evolved into mixed vitiligo; 56 were male and 71 were female. Most patients had onset of segmental vitiligo before the age of 18. When conducting multivariate analysis, we found the following to be independent factors associated with the evolution of patients’ disease from segmental vitiligo to mixed vitiligo: initial percentage of body surface involvement of the segment > 1% [odds ratio (OR) 15·14, P = 0·002], the presence of halo naevi (OR 24·82, P = 0·0001) and leukotrichia (OR 25·73, P = 0·0009).
Conclusions Halo naevi association and leukotrichia at first consultation in segmental vitiligo are risk factors for the progression of segmental vitiligo to mixed vitiligo. In addition, this progression of segmental vitiligo to mixed vitiligo carries a stronger link if initial segmental involvement is situated on the trunk.
See also the Commentary by Picardo</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>22032627</pmid><doi>10.1111/j.1365-2133.2011.10709.x</doi><tpages>6</tpages></addata></record> |
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| ispartof | British journal of dermatology (1951), 2012-03, Vol.166 (3), p.539-544 |
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| source | MEDLINE; Access via Wiley Online Library; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Adolescent Adult Age of Onset Biological and medical sciences Child Child, Preschool Dermatology Disease Progression Female Hair Color Hair Diseases - complications Humans Infant Male Medical sciences Multivariate Analysis Nevus, Halo - complications Pigmentary diseases of the skin Prospective Studies Risk Factors Tumors of the skin and soft tissue. Premalignant lesions Vitiligo - etiology Young Adult |
| title | Halo naevi and leukotrichia are strong predictors of the passage to mixed vitiligo in a subgroup of segmental vitiligo |
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