Low serum high-density lipoprotein cholesterol in childhood is associated with adolescent asthma
Summary Background Whilst emerging evidence from animal and cell experiments has shown high‐density lipoprotein cholesterol to have anti‐inflammatory effects consistent with a protective role in asthma, human studies investigating the relationship of high‐density lipoprotein cholesterol with asthma...
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| Veröffentlicht in: | Clinical and experimental allergy 2012-03, Vol.42 (3), p.423-432 |
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| creator | Yiallouros, P. K. Savva, S. C. Kolokotroni, O. Behbod, B. Zeniou, M. Economou, M. Chadjigeorgiou, C. Kourides, Y. A. Tornaritis, M. J. Lamnisos, D. Middleton, N. Milton, D. K. |
| description | Summary
Background
Whilst emerging evidence from animal and cell experiments has shown high‐density lipoprotein cholesterol to have anti‐inflammatory effects consistent with a protective role in asthma, human studies investigating the relationship of high‐density lipoprotein cholesterol with asthma have produced conflicting results.
Objective
To examine the association between serum lipids among Cypriot children aged 11–12 years and prevalence of asthma at age 15–17 years.
Methods
In 3982 children, we assessed serum lipids, body mass index and maximal oxygen consumption at baseline (2001–2003) and explored associations with respiratory health at follow‐up (2007) using multiple logistic regression models.
Results
Lower levels of high‐density lipoprotein cholesterol at age 11–12 years were found in subjects who reported ever asthma (58.2 vs. 60.0 mg/dL, P = 0.005) and active asthma (57.5 vs. 59.9 mg/dL, P = 0.010) in adolescence, in comparison with their respective reference groups. Total cholesterol, low‐density lipoprotein and triglycerides had no association with any of the asthma outcomes. In contrast, with estimated odds ratios of 1.89 (95% CI 1.19–3.00) and 1.89 (95% CI 1.02–3.53), ever asthma and active asthma respectively appeared particularly pronounced among those who at baseline had high‐density lipoprotein cholesterol |
| doi_str_mv | 10.1111/j.1365-2222.2011.03940.x |
| format | Article |
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Background
Whilst emerging evidence from animal and cell experiments has shown high‐density lipoprotein cholesterol to have anti‐inflammatory effects consistent with a protective role in asthma, human studies investigating the relationship of high‐density lipoprotein cholesterol with asthma have produced conflicting results.
Objective
To examine the association between serum lipids among Cypriot children aged 11–12 years and prevalence of asthma at age 15–17 years.
Methods
In 3982 children, we assessed serum lipids, body mass index and maximal oxygen consumption at baseline (2001–2003) and explored associations with respiratory health at follow‐up (2007) using multiple logistic regression models.
Results
Lower levels of high‐density lipoprotein cholesterol at age 11–12 years were found in subjects who reported ever asthma (58.2 vs. 60.0 mg/dL, P = 0.005) and active asthma (57.5 vs. 59.9 mg/dL, P = 0.010) in adolescence, in comparison with their respective reference groups. Total cholesterol, low‐density lipoprotein and triglycerides had no association with any of the asthma outcomes. In contrast, with estimated odds ratios of 1.89 (95% CI 1.19–3.00) and 1.89 (95% CI 1.02–3.53), ever asthma and active asthma respectively appeared particularly pronounced among those who at baseline had high‐density lipoprotein cholesterol <40 mg/dL, even after adjusting for potential confounders including body mass index and maximal oxygen consumption.
Conclusions & Clinical Relevance
Low‐serum high‐density lipoprotein cholesterol in childhood is associated with an increased risk for asthma in adolescence, suggesting a potential role of this lipoprotein in the pathogenesis of paediatric asthma.</description><identifier>ISSN: 0954-7894</identifier><identifier>EISSN: 1365-2222</identifier><identifier>DOI: 10.1111/j.1365-2222.2011.03940.x</identifier><identifier>PMID: 22356143</identifier><language>eng</language><publisher>Oxford: Blackwell Publishing Ltd</publisher><subject>adiposity ; Adolescence ; Adolescent ; adolescents ; Age ; Asthma ; Asthma - blood ; Asthma - epidemiology ; Biological and medical sciences ; Body Mass Index ; Children ; Cholesterol ; Cholesterol, HDL - blood ; Cholesterol, HDL - immunology ; Chronic obstructive pulmonary disease, asthma ; Female ; Follow-Up Studies ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; high-density lipoprotein cholesterol ; Humans ; Inflammation ; Lipoproteins ; Male ; Medical sciences ; Oxygen consumption ; Pediatrics ; Physical Fitness ; Pneumology ; Prevalence ; Regression analysis ; Serum lipids ; Triglycerides</subject><ispartof>Clinical and experimental allergy, 2012-03, Vol.42 (3), p.423-432</ispartof><rights>2011 Blackwell Publishing Ltd</rights><rights>2015 INIST-CNRS</rights><rights>2011 Blackwell Publishing Ltd.</rights><rights>Copyright © 2012 Blackwell Publishing Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4970-23bec8a7cb589a93138390fae78fae240cd96c7fec272d2ad277fa67277e89403</citedby><cites>FETCH-LOGICAL-c4970-23bec8a7cb589a93138390fae78fae240cd96c7fec272d2ad277fa67277e89403</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2222.2011.03940.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2222.2011.03940.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25566413$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22356143$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yiallouros, P. K.</creatorcontrib><creatorcontrib>Savva, S. C.</creatorcontrib><creatorcontrib>Kolokotroni, O.</creatorcontrib><creatorcontrib>Behbod, B.</creatorcontrib><creatorcontrib>Zeniou, M.</creatorcontrib><creatorcontrib>Economou, M.</creatorcontrib><creatorcontrib>Chadjigeorgiou, C.</creatorcontrib><creatorcontrib>Kourides, Y. A.</creatorcontrib><creatorcontrib>Tornaritis, M. J.</creatorcontrib><creatorcontrib>Lamnisos, D.</creatorcontrib><creatorcontrib>Middleton, N.</creatorcontrib><creatorcontrib>Milton, D. K.</creatorcontrib><title>Low serum high-density lipoprotein cholesterol in childhood is associated with adolescent asthma</title><title>Clinical and experimental allergy</title><addtitle>Clin Exp Allergy</addtitle><description>Summary
Background
Whilst emerging evidence from animal and cell experiments has shown high‐density lipoprotein cholesterol to have anti‐inflammatory effects consistent with a protective role in asthma, human studies investigating the relationship of high‐density lipoprotein cholesterol with asthma have produced conflicting results.
Objective
To examine the association between serum lipids among Cypriot children aged 11–12 years and prevalence of asthma at age 15–17 years.
Methods
In 3982 children, we assessed serum lipids, body mass index and maximal oxygen consumption at baseline (2001–2003) and explored associations with respiratory health at follow‐up (2007) using multiple logistic regression models.
Results
Lower levels of high‐density lipoprotein cholesterol at age 11–12 years were found in subjects who reported ever asthma (58.2 vs. 60.0 mg/dL, P = 0.005) and active asthma (57.5 vs. 59.9 mg/dL, P = 0.010) in adolescence, in comparison with their respective reference groups. Total cholesterol, low‐density lipoprotein and triglycerides had no association with any of the asthma outcomes. In contrast, with estimated odds ratios of 1.89 (95% CI 1.19–3.00) and 1.89 (95% CI 1.02–3.53), ever asthma and active asthma respectively appeared particularly pronounced among those who at baseline had high‐density lipoprotein cholesterol <40 mg/dL, even after adjusting for potential confounders including body mass index and maximal oxygen consumption.
Conclusions & Clinical Relevance
Low‐serum high‐density lipoprotein cholesterol in childhood is associated with an increased risk for asthma in adolescence, suggesting a potential role of this lipoprotein in the pathogenesis of paediatric asthma.</description><subject>adiposity</subject><subject>Adolescence</subject><subject>Adolescent</subject><subject>adolescents</subject><subject>Age</subject><subject>Asthma</subject><subject>Asthma - blood</subject><subject>Asthma - epidemiology</subject><subject>Biological and medical sciences</subject><subject>Body Mass Index</subject><subject>Children</subject><subject>Cholesterol</subject><subject>Cholesterol, HDL - blood</subject><subject>Cholesterol, HDL - immunology</subject><subject>Chronic obstructive pulmonary disease, asthma</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>high-density lipoprotein cholesterol</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Lipoproteins</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Oxygen consumption</subject><subject>Pediatrics</subject><subject>Physical Fitness</subject><subject>Pneumology</subject><subject>Prevalence</subject><subject>Regression analysis</subject><subject>Serum lipids</subject><subject>Triglycerides</subject><issn>0954-7894</issn><issn>1365-2222</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU2P0zAQhi0EYrsLfwFZQgguCf6IY_vAYVUtC6sKDoDgZlzHIS5JXOxEbf_9Ok0pEgfEHDyy5pnXM34BgBjlOMXrTY5pyTKSIicI4xxRWaB8_wAszoWHYIEkKzIuZHEBLmPcIIQok-IxuCCEshIXdAG-r_wORhvGDjbuR5NVto9uOMDWbf02-MG6HprGtzYONvgWHq-urRrvK-gi1DF64_RgK7hzQwN1NbHG9kMqDU2nn4BHtW6jfXrKV-DL25vPy3fZ6uPt--X1KjOF5CgjdG2N0NysmZBaUkwFlajWlot0kAKZSpaG19YQTiqiK8J5rUuekk0LInoFXs66aepfYxpXdS7N0ba6t36MSqaVedKViXz1TxIjIhBFSOCEPv8L3fgx9GkPhVmR9Ep2pMRMmeBjDLZW2-A6HQ5JSk1-qY2abFGTLWrySx39UvvU-uz0wLjubHVu_G1QAl6cAB2Nbuuge-PiH46xsizwxL2ZuZ1r7eG_B1DLm2s6f18297tk9P7cr8NPVXLKmfr64VaJu-ITL---KUrvAQQ8v10</recordid><startdate>201203</startdate><enddate>201203</enddate><creator>Yiallouros, P. K.</creator><creator>Savva, S. C.</creator><creator>Kolokotroni, O.</creator><creator>Behbod, B.</creator><creator>Zeniou, M.</creator><creator>Economou, M.</creator><creator>Chadjigeorgiou, C.</creator><creator>Kourides, Y. A.</creator><creator>Tornaritis, M. J.</creator><creator>Lamnisos, D.</creator><creator>Middleton, N.</creator><creator>Milton, D. K.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201203</creationdate><title>Low serum high-density lipoprotein cholesterol in childhood is associated with adolescent asthma</title><author>Yiallouros, P. K. ; Savva, S. C. ; Kolokotroni, O. ; Behbod, B. ; Zeniou, M. ; Economou, M. ; Chadjigeorgiou, C. ; Kourides, Y. A. ; Tornaritis, M. J. ; Lamnisos, D. ; Middleton, N. ; Milton, D. K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4970-23bec8a7cb589a93138390fae78fae240cd96c7fec272d2ad277fa67277e89403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>adiposity</topic><topic>Adolescence</topic><topic>Adolescent</topic><topic>adolescents</topic><topic>Age</topic><topic>Asthma</topic><topic>Asthma - blood</topic><topic>Asthma - epidemiology</topic><topic>Biological and medical sciences</topic><topic>Body Mass Index</topic><topic>Children</topic><topic>Cholesterol</topic><topic>Cholesterol, HDL - blood</topic><topic>Cholesterol, HDL - immunology</topic><topic>Chronic obstructive pulmonary disease, asthma</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>high-density lipoprotein cholesterol</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Lipoproteins</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Oxygen consumption</topic><topic>Pediatrics</topic><topic>Physical Fitness</topic><topic>Pneumology</topic><topic>Prevalence</topic><topic>Regression analysis</topic><topic>Serum lipids</topic><topic>Triglycerides</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yiallouros, P. K.</creatorcontrib><creatorcontrib>Savva, S. C.</creatorcontrib><creatorcontrib>Kolokotroni, O.</creatorcontrib><creatorcontrib>Behbod, B.</creatorcontrib><creatorcontrib>Zeniou, M.</creatorcontrib><creatorcontrib>Economou, M.</creatorcontrib><creatorcontrib>Chadjigeorgiou, C.</creatorcontrib><creatorcontrib>Kourides, Y. A.</creatorcontrib><creatorcontrib>Tornaritis, M. J.</creatorcontrib><creatorcontrib>Lamnisos, D.</creatorcontrib><creatorcontrib>Middleton, N.</creatorcontrib><creatorcontrib>Milton, D. K.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental allergy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yiallouros, P. K.</au><au>Savva, S. C.</au><au>Kolokotroni, O.</au><au>Behbod, B.</au><au>Zeniou, M.</au><au>Economou, M.</au><au>Chadjigeorgiou, C.</au><au>Kourides, Y. A.</au><au>Tornaritis, M. J.</au><au>Lamnisos, D.</au><au>Middleton, N.</au><au>Milton, D. K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low serum high-density lipoprotein cholesterol in childhood is associated with adolescent asthma</atitle><jtitle>Clinical and experimental allergy</jtitle><addtitle>Clin Exp Allergy</addtitle><date>2012-03</date><risdate>2012</risdate><volume>42</volume><issue>3</issue><spage>423</spage><epage>432</epage><pages>423-432</pages><issn>0954-7894</issn><eissn>1365-2222</eissn><abstract>Summary
Background
Whilst emerging evidence from animal and cell experiments has shown high‐density lipoprotein cholesterol to have anti‐inflammatory effects consistent with a protective role in asthma, human studies investigating the relationship of high‐density lipoprotein cholesterol with asthma have produced conflicting results.
Objective
To examine the association between serum lipids among Cypriot children aged 11–12 years and prevalence of asthma at age 15–17 years.
Methods
In 3982 children, we assessed serum lipids, body mass index and maximal oxygen consumption at baseline (2001–2003) and explored associations with respiratory health at follow‐up (2007) using multiple logistic regression models.
Results
Lower levels of high‐density lipoprotein cholesterol at age 11–12 years were found in subjects who reported ever asthma (58.2 vs. 60.0 mg/dL, P = 0.005) and active asthma (57.5 vs. 59.9 mg/dL, P = 0.010) in adolescence, in comparison with their respective reference groups. Total cholesterol, low‐density lipoprotein and triglycerides had no association with any of the asthma outcomes. In contrast, with estimated odds ratios of 1.89 (95% CI 1.19–3.00) and 1.89 (95% CI 1.02–3.53), ever asthma and active asthma respectively appeared particularly pronounced among those who at baseline had high‐density lipoprotein cholesterol <40 mg/dL, even after adjusting for potential confounders including body mass index and maximal oxygen consumption.
Conclusions & Clinical Relevance
Low‐serum high‐density lipoprotein cholesterol in childhood is associated with an increased risk for asthma in adolescence, suggesting a potential role of this lipoprotein in the pathogenesis of paediatric asthma.</abstract><cop>Oxford</cop><pub>Blackwell Publishing Ltd</pub><pmid>22356143</pmid><doi>10.1111/j.1365-2222.2011.03940.x</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0954-7894 |
| ispartof | Clinical and experimental allergy, 2012-03, Vol.42 (3), p.423-432 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library |
| subjects | adiposity Adolescence Adolescent adolescents Age Asthma Asthma - blood Asthma - epidemiology Biological and medical sciences Body Mass Index Children Cholesterol Cholesterol, HDL - blood Cholesterol, HDL - immunology Chronic obstructive pulmonary disease, asthma Female Follow-Up Studies Fundamental and applied biological sciences. Psychology Fundamental immunology high-density lipoprotein cholesterol Humans Inflammation Lipoproteins Male Medical sciences Oxygen consumption Pediatrics Physical Fitness Pneumology Prevalence Regression analysis Serum lipids Triglycerides |
| title | Low serum high-density lipoprotein cholesterol in childhood is associated with adolescent asthma |
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