Small-Molecule Stabilization of Protein-Protein Interactions: An Underestimated Concept in Drug Discovery?

The modulation of protein–protein interactions (PPIs) has been recognized as one of the most challenging tasks in drug discovery. While their systematic development has long been considered as intractable, this view has changed over the last years, with the first drug candidates undergoing clinical...

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Veröffentlicht in:	Angewandte Chemie International Edition 2012-02, Vol.51 (9), p.2012-2018
Hauptverfasser:	Thiel, Philipp, Kaiser, Markus, Ottmann, Christian
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Products - chemistry Biological Products - pharmacology Construction drug design Drug Discovery - methods Drugs Humans Inhibitors Medical research Models, Molecular Modulation Modulators Pharmaceutical industry Protein Binding - drug effects Protein Interaction Mapping protein-protein interaction Proteins Proteins - chemistry Proteins - metabolism Recognition Small Molecule Libraries - chemistry Small Molecule Libraries - pharmacology small-molecule drugs Stabilization Strategy Tasks
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