FOXP3 and FOXP3-regulated microRNAs suppress SATB1 in breast cancer cells

The transcription factor FOXP3 has been identified as a tumour suppressor in the breast and prostate epithelia, but little is known about its specific mechanism of action. We have identified a feed-forward regulatory loop in which FOXP3 suppresses the expression of the oncogene SATB1. In particular,...

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Veröffentlicht in:	Oncogene 2012-02, Vol.31 (8), p.1045-1054
Hauptverfasser:	McInnes, N, Sadlon, T J, Brown, C Y, Pederson, S, Beyer, M, Schultze, J L, McColl, S, Goodall, G J, Barry, S C
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated regions Apoptosis Breast cancer Breast Neoplasms Care and treatment Cell Biology Cell Line, Tumor Cell Proliferation Down-Regulation Epithelium Female Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism Foxp3 protein Gene Expression Gene Expression Regulation, Neoplastic Genes, Reporter Genetic aspects Genomics Human Genetics Humans Internal Medicine Luciferases, Firefly - biosynthesis Luciferases, Firefly - genetics Matrix Attachment Region Binding Proteins - genetics Matrix Attachment Region Binding Proteins - metabolism Medicine Medicine & Public Health MicroRNA MicroRNAs - genetics MicroRNAs - metabolism miRNA Oncogenes Oncology original-article Phenotypes Physiological aspects Promoter Regions, Genetic Prostate Ribonucleic acid RNA RNA Interference Transcription factors Transformation Tumor suppressor genes Tumors
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