Antibacterial activities of dendritic amphiphiles against nontuberculous mycobacteria

Summary The anti-mycobacterial activities of nine series of dicarboxyl and tricarboxyl dendritic amphiphiles with one alkyl, two alkyl, and cholestanyl tails against Mycobacterium abscessus, Mycobacterium avium, Mycobacterium chelonae, Mycobacterium marinum and Mycobacterium smegmatis have been meas...

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Veröffentlicht in:	Tuberculosis (Edinburgh, Scotland) Scotland), 2012-03, Vol.92 (2), p.173-181
Hauptverfasser:	Falkinham, Joseph O, Macri, Richard V, Maisuria, Bhadreshkumar B, Actis, Marcelo L, Sugandhi, Eko W, Williams, André A, Snyder, Alyson V, Jackson, Faunice R, Poppe, Michael A, Chen, Liang, Ganesh, Krithika, Gandour, Richard D
Format:	Artikel
Sprache:	eng
Schlagworte:	alcohols amines Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Anti-mycobacterial agents Antibacterial activity Antibiotics Biofilms - drug effects Critical micelle concentration Dendrimers - chemistry Dendrimers - pharmacology Dendritic amphiphiles Drug Evaluation, Preclinical - methods Drug Resistance, Bacterial Fatty acids Hemolysis - drug effects Hemolytic activity Humans Infectious Disease Membrane Fluidity - drug effects Micelles Microbial Sensitivity Tests - methods Mycobacterium abscessus Mycobacterium avium Mycobacterium avium - drug effects Mycobacterium avium - growth & development Mycobacterium avium - physiology Mycobacterium chelonae Mycobacterium marinum Mycobacterium smegmatis Nontuberculous mycobacteria Nontuberculous Mycobacteria - classification Nontuberculous Mycobacteria - drug effects Nontuberculous Mycobacteria - growth & development Nontuberculous Mycobacteria - physiology Physicochemical properties Pulmonary/Respiratory Solubility Species Specificity Structure-Activity Relationship Tails Temperature Tuberculosis
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