Intrauterine myelomeningocele repair Postnatal results and follow-up at 3.5 years of age — initial experience from a single reference service in Brazil
Purpose Present the outcomes of six cases submitted to intrauterine myelomeningocele (MMC) repair. Methods Descriptive observational study of six children submitted to antenatal surgical repair of MMC between 26 and 27 weeks gestation. All deliveries were through cesarean section. The following neon...
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| Veröffentlicht in: | Child's nervous system 2012-03, Vol.28 (3), p.461-467 |
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| creator | Hisaba, Wagner Jou Cavalheiro, Sérgio Almodim, Carlos Gilberto Borges, Carolina Peixoto de Faria, Tereza Cristina Carbonari Araujo Júnior, Edward Nardozza, Luciano Marcondes Machado Moron, Antonio Fernandes |
| description | Purpose
Present the outcomes of six cases submitted to intrauterine myelomeningocele (MMC) repair.
Methods
Descriptive observational study of six children submitted to antenatal surgical repair of MMC between 26 and 27 weeks gestation. All deliveries were through cesarean section. The following neonatal variables were assessed: gestational age at delivery, birth weight, Apgar scores, need for intubation, duration of hospital stay and need for postnatal shunt procedures. After 3.5 years, the children were evaluated using the Columbia Mental Maturity Scale or Denver II tests and the Hoffer Ambulation Scale.
Results
All deliveries were preterm at a mean gestational age of 32 + 4 weeks and mean birth weight was 1,942 g. Two infants had Apgar scores |
| doi_str_mv | 10.1007/s00381-011-1662-z |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_923575348</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>923575348</sourcerecordid><originalsourceid>FETCH-LOGICAL-c409t-a78f1f1c41ac4b032908a2f4b8b02b9aafdca4f47882c574eb513c24ddb561103</originalsourceid><addsrcrecordid>eNp9kc1u1DAQxy0EokvhAbgg3ziljL82yREqPipVggOcrUkyXrlK7GAn0N0TD8GJE8_Co_AkuN3CkdNI4_-HRz_Gngo4EwD1iwygGlGBEJXYbmV1uMc2QitVgTJwn21Amm1Vg4YT9ijnKwBhGtk-ZCdSSjBGiQ37cRGWhOtCyQfi057GOFHwYRd7GoknmtEn_iHmJeCCY1nkdVwyxzBwF8cxfq3WmePC1Zn59XNPmDKPjuOO-O9v37kPfvHFRtdzaaDQE3cpThx5Lh23BY7S7T5T-uLL9IG_Snjw42P2wOGY6cndPGWf3rz-eP6uunz_9uL85WXVa2iXCuvGCSd6LbDXHSjZQoPS6a7pQHYtoht61E7XTSN7U2vqjFC91MPQma0QoE7Z82PunOLnlfJiJ5_L9SMGimu2rVSmNko3RSmOyj7FnMvX7Zz8hGlvBdgbIvZIxBYi9oaIPRTPs7v0tZto-Of4i6AI5FGQy1PYUbJXcU2hXPyf1D95-5uE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>923575348</pqid></control><display><type>article</type><title>Intrauterine myelomeningocele repair Postnatal results and follow-up at 3.5 years of age — initial experience from a single reference service in Brazil</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Hisaba, Wagner Jou ; Cavalheiro, Sérgio ; Almodim, Carlos Gilberto ; Borges, Carolina Peixoto ; de Faria, Tereza Cristina Carbonari ; Araujo Júnior, Edward ; Nardozza, Luciano Marcondes Machado ; Moron, Antonio Fernandes</creator><creatorcontrib>Hisaba, Wagner Jou ; Cavalheiro, Sérgio ; Almodim, Carlos Gilberto ; Borges, Carolina Peixoto ; de Faria, Tereza Cristina Carbonari ; Araujo Júnior, Edward ; Nardozza, Luciano Marcondes Machado ; Moron, Antonio Fernandes</creatorcontrib><description>Purpose
Present the outcomes of six cases submitted to intrauterine myelomeningocele (MMC) repair.
Methods
Descriptive observational study of six children submitted to antenatal surgical repair of MMC between 26 and 27 weeks gestation. All deliveries were through cesarean section. The following neonatal variables were assessed: gestational age at delivery, birth weight, Apgar scores, need for intubation, duration of hospital stay and need for postnatal shunt procedures. After 3.5 years, the children were evaluated using the Columbia Mental Maturity Scale or Denver II tests and the Hoffer Ambulation Scale.
Results
All deliveries were preterm at a mean gestational age of 32 + 4 weeks and mean birth weight was 1,942 g. Two infants had Apgar scores <7 at 1 min and 1 at 5 min. Ventricular–peritoneal shunts were placed in two cases. All six children are alive: five have normal cognitive development and one has a neuropsychomotor developmental delay. Two children had normal leg movements, a sacral functional level and are community ambulators. Three children had upper lumbar anatomical level lesions and one had a lower thoracic level lesion at the time of fetal surgery. One child, with an L1–L2 anatomical level lesion, in noambulatory and fully dependent on a wheelchair for mobility.
Conclusion
Antenatal surgical repair of MMC reduced the need for postnatal shunt placements. Despite preterm delivery, the cognitive development of most children at 3.5 years was normal. Antenatal surgery seemed to improve lower limb motor function in these cases.</description><identifier>ISSN: 0256-7040</identifier><identifier>EISSN: 1433-0350</identifier><identifier>DOI: 10.1007/s00381-011-1662-z</identifier><identifier>PMID: 22205531</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Brazil ; Child, Preschool ; Delivery, Obstetric ; Female ; Fetal Diseases - diagnostic imaging ; Fetal Diseases - physiopathology ; Fetal Diseases - surgery ; Gestational Age ; Humans ; Hysterotomy - methods ; Infant, Newborn ; Longitudinal Studies ; Male ; Medicine ; Medicine & Public Health ; Meningomyelocele - diagnostic imaging ; Meningomyelocele - physiopathology ; Meningomyelocele - surgery ; Neurosciences ; Neurosurgery ; Original Paper ; Pregnancy ; Pregnancy Complications - surgery ; Pregnancy, High-Risk ; Retrospective Studies ; Ultrasonography, Prenatal</subject><ispartof>Child's nervous system, 2012-03, Vol.28 (3), p.461-467</ispartof><rights>Springer-Verlag 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c409t-a78f1f1c41ac4b032908a2f4b8b02b9aafdca4f47882c574eb513c24ddb561103</citedby><cites>FETCH-LOGICAL-c409t-a78f1f1c41ac4b032908a2f4b8b02b9aafdca4f47882c574eb513c24ddb561103</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00381-011-1662-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00381-011-1662-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22205531$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hisaba, Wagner Jou</creatorcontrib><creatorcontrib>Cavalheiro, Sérgio</creatorcontrib><creatorcontrib>Almodim, Carlos Gilberto</creatorcontrib><creatorcontrib>Borges, Carolina Peixoto</creatorcontrib><creatorcontrib>de Faria, Tereza Cristina Carbonari</creatorcontrib><creatorcontrib>Araujo Júnior, Edward</creatorcontrib><creatorcontrib>Nardozza, Luciano Marcondes Machado</creatorcontrib><creatorcontrib>Moron, Antonio Fernandes</creatorcontrib><title>Intrauterine myelomeningocele repair Postnatal results and follow-up at 3.5 years of age — initial experience from a single reference service in Brazil</title><title>Child's nervous system</title><addtitle>Childs Nerv Syst</addtitle><addtitle>Childs Nerv Syst</addtitle><description>Purpose
Present the outcomes of six cases submitted to intrauterine myelomeningocele (MMC) repair.
Methods
Descriptive observational study of six children submitted to antenatal surgical repair of MMC between 26 and 27 weeks gestation. All deliveries were through cesarean section. The following neonatal variables were assessed: gestational age at delivery, birth weight, Apgar scores, need for intubation, duration of hospital stay and need for postnatal shunt procedures. After 3.5 years, the children were evaluated using the Columbia Mental Maturity Scale or Denver II tests and the Hoffer Ambulation Scale.
Results
All deliveries were preterm at a mean gestational age of 32 + 4 weeks and mean birth weight was 1,942 g. Two infants had Apgar scores <7 at 1 min and 1 at 5 min. Ventricular–peritoneal shunts were placed in two cases. All six children are alive: five have normal cognitive development and one has a neuropsychomotor developmental delay. Two children had normal leg movements, a sacral functional level and are community ambulators. Three children had upper lumbar anatomical level lesions and one had a lower thoracic level lesion at the time of fetal surgery. One child, with an L1–L2 anatomical level lesion, in noambulatory and fully dependent on a wheelchair for mobility.
Conclusion
Antenatal surgical repair of MMC reduced the need for postnatal shunt placements. Despite preterm delivery, the cognitive development of most children at 3.5 years was normal. Antenatal surgery seemed to improve lower limb motor function in these cases.</description><subject>Brazil</subject><subject>Child, Preschool</subject><subject>Delivery, Obstetric</subject><subject>Female</subject><subject>Fetal Diseases - diagnostic imaging</subject><subject>Fetal Diseases - physiopathology</subject><subject>Fetal Diseases - surgery</subject><subject>Gestational Age</subject><subject>Humans</subject><subject>Hysterotomy - methods</subject><subject>Infant, Newborn</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Meningomyelocele - diagnostic imaging</subject><subject>Meningomyelocele - physiopathology</subject><subject>Meningomyelocele - surgery</subject><subject>Neurosciences</subject><subject>Neurosurgery</subject><subject>Original Paper</subject><subject>Pregnancy</subject><subject>Pregnancy Complications - surgery</subject><subject>Pregnancy, High-Risk</subject><subject>Retrospective Studies</subject><subject>Ultrasonography, Prenatal</subject><issn>0256-7040</issn><issn>1433-0350</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1DAQxy0EokvhAbgg3ziljL82yREqPipVggOcrUkyXrlK7GAn0N0TD8GJE8_Co_AkuN3CkdNI4_-HRz_Gngo4EwD1iwygGlGBEJXYbmV1uMc2QitVgTJwn21Amm1Vg4YT9ijnKwBhGtk-ZCdSSjBGiQ37cRGWhOtCyQfi057GOFHwYRd7GoknmtEn_iHmJeCCY1nkdVwyxzBwF8cxfq3WmePC1Zn59XNPmDKPjuOO-O9v37kPfvHFRtdzaaDQE3cpThx5Lh23BY7S7T5T-uLL9IG_Snjw42P2wOGY6cndPGWf3rz-eP6uunz_9uL85WXVa2iXCuvGCSd6LbDXHSjZQoPS6a7pQHYtoht61E7XTSN7U2vqjFC91MPQma0QoE7Z82PunOLnlfJiJ5_L9SMGimu2rVSmNko3RSmOyj7FnMvX7Zz8hGlvBdgbIvZIxBYi9oaIPRTPs7v0tZto-Of4i6AI5FGQy1PYUbJXcU2hXPyf1D95-5uE</recordid><startdate>20120301</startdate><enddate>20120301</enddate><creator>Hisaba, Wagner Jou</creator><creator>Cavalheiro, Sérgio</creator><creator>Almodim, Carlos Gilberto</creator><creator>Borges, Carolina Peixoto</creator><creator>de Faria, Tereza Cristina Carbonari</creator><creator>Araujo Júnior, Edward</creator><creator>Nardozza, Luciano Marcondes Machado</creator><creator>Moron, Antonio Fernandes</creator><general>Springer-Verlag</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120301</creationdate><title>Intrauterine myelomeningocele repair Postnatal results and follow-up at 3.5 years of age — initial experience from a single reference service in Brazil</title><author>Hisaba, Wagner Jou ; Cavalheiro, Sérgio ; Almodim, Carlos Gilberto ; Borges, Carolina Peixoto ; de Faria, Tereza Cristina Carbonari ; Araujo Júnior, Edward ; Nardozza, Luciano Marcondes Machado ; Moron, Antonio Fernandes</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c409t-a78f1f1c41ac4b032908a2f4b8b02b9aafdca4f47882c574eb513c24ddb561103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Brazil</topic><topic>Child, Preschool</topic><topic>Delivery, Obstetric</topic><topic>Female</topic><topic>Fetal Diseases - diagnostic imaging</topic><topic>Fetal Diseases - physiopathology</topic><topic>Fetal Diseases - surgery</topic><topic>Gestational Age</topic><topic>Humans</topic><topic>Hysterotomy - methods</topic><topic>Infant, Newborn</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Meningomyelocele - diagnostic imaging</topic><topic>Meningomyelocele - physiopathology</topic><topic>Meningomyelocele - surgery</topic><topic>Neurosciences</topic><topic>Neurosurgery</topic><topic>Original Paper</topic><topic>Pregnancy</topic><topic>Pregnancy Complications - surgery</topic><topic>Pregnancy, High-Risk</topic><topic>Retrospective Studies</topic><topic>Ultrasonography, Prenatal</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hisaba, Wagner Jou</creatorcontrib><creatorcontrib>Cavalheiro, Sérgio</creatorcontrib><creatorcontrib>Almodim, Carlos Gilberto</creatorcontrib><creatorcontrib>Borges, Carolina Peixoto</creatorcontrib><creatorcontrib>de Faria, Tereza Cristina Carbonari</creatorcontrib><creatorcontrib>Araujo Júnior, Edward</creatorcontrib><creatorcontrib>Nardozza, Luciano Marcondes Machado</creatorcontrib><creatorcontrib>Moron, Antonio Fernandes</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Child's nervous system</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hisaba, Wagner Jou</au><au>Cavalheiro, Sérgio</au><au>Almodim, Carlos Gilberto</au><au>Borges, Carolina Peixoto</au><au>de Faria, Tereza Cristina Carbonari</au><au>Araujo Júnior, Edward</au><au>Nardozza, Luciano Marcondes Machado</au><au>Moron, Antonio Fernandes</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intrauterine myelomeningocele repair Postnatal results and follow-up at 3.5 years of age — initial experience from a single reference service in Brazil</atitle><jtitle>Child's nervous system</jtitle><stitle>Childs Nerv Syst</stitle><addtitle>Childs Nerv Syst</addtitle><date>2012-03-01</date><risdate>2012</risdate><volume>28</volume><issue>3</issue><spage>461</spage><epage>467</epage><pages>461-467</pages><issn>0256-7040</issn><eissn>1433-0350</eissn><abstract>Purpose
Present the outcomes of six cases submitted to intrauterine myelomeningocele (MMC) repair.
Methods
Descriptive observational study of six children submitted to antenatal surgical repair of MMC between 26 and 27 weeks gestation. All deliveries were through cesarean section. The following neonatal variables were assessed: gestational age at delivery, birth weight, Apgar scores, need for intubation, duration of hospital stay and need for postnatal shunt procedures. After 3.5 years, the children were evaluated using the Columbia Mental Maturity Scale or Denver II tests and the Hoffer Ambulation Scale.
Results
All deliveries were preterm at a mean gestational age of 32 + 4 weeks and mean birth weight was 1,942 g. Two infants had Apgar scores <7 at 1 min and 1 at 5 min. Ventricular–peritoneal shunts were placed in two cases. All six children are alive: five have normal cognitive development and one has a neuropsychomotor developmental delay. Two children had normal leg movements, a sacral functional level and are community ambulators. Three children had upper lumbar anatomical level lesions and one had a lower thoracic level lesion at the time of fetal surgery. One child, with an L1–L2 anatomical level lesion, in noambulatory and fully dependent on a wheelchair for mobility.
Conclusion
Antenatal surgical repair of MMC reduced the need for postnatal shunt placements. Despite preterm delivery, the cognitive development of most children at 3.5 years was normal. Antenatal surgery seemed to improve lower limb motor function in these cases.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>22205531</pmid><doi>10.1007/s00381-011-1662-z</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0256-7040 |
| ispartof | Child's nervous system, 2012-03, Vol.28 (3), p.461-467 |
| issn | 0256-7040 1433-0350 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Brazil Child, Preschool Delivery, Obstetric Female Fetal Diseases - diagnostic imaging Fetal Diseases - physiopathology Fetal Diseases - surgery Gestational Age Humans Hysterotomy - methods Infant, Newborn Longitudinal Studies Male Medicine Medicine & Public Health Meningomyelocele - diagnostic imaging Meningomyelocele - physiopathology Meningomyelocele - surgery Neurosciences Neurosurgery Original Paper Pregnancy Pregnancy Complications - surgery Pregnancy, High-Risk Retrospective Studies Ultrasonography, Prenatal |
| title | Intrauterine myelomeningocele repair Postnatal results and follow-up at 3.5 years of age — initial experience from a single reference service in Brazil |
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