Evaluation of Native Kidney Recovery After Simultaneous Liver-Kidney Transplantation
Debate continues about which liver transplantation candidates with impaired renal function should undergo liver transplant alone versus simultaneous liver-kidney transplantation (SLK). Identifying predictors of native kidney function recovery after SLK requires an accurate measure of the relative fu...
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| Veröffentlicht in: | Transplantation 2012-03, Vol.93 (5), p.530-535 |
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| creator | FRANCIS, Jean M PALMER, Matthew R DONOHOE, Kevin CURRY, Michael JOHNSON, Scott R KARP, Seth J EVENSON, Amy R PAVLAKIS, Martha HANTO, Douglas W MANDELBROT, Didier A |
| description | Debate continues about which liver transplantation candidates with impaired renal function should undergo liver transplant alone versus simultaneous liver-kidney transplantation (SLK). Identifying predictors of native kidney function recovery after SLK requires an accurate measure of the relative function of all three kidneys in patients with SLK.
The distance of a transplanted kidney from the renal scan camera can be substantially different from that of native kidneys. We developed a technique to correct attenuation of counts of all three kidneys based on their depth.
In our series of 13 SLK recipients, attenuation correction increased the measured renal function of native kidneys by up to 40%, demonstrating the importance of this procedure for accurately measuring kidney function. Eight patients met the United Network for Organ Sharing (UNOS)-proposed criteria for receiving a SLK, but four of these still had significant native kidney function (>40% of total function) after transplant. Five patients did not meet the UNOS-proposed criteria for SLK, yet only one of these had native kidney function recovery.
The criteria proposed by UNOS to determine that SLK is indicated, and thus that native kidney recovery is not expected, are not always accurate. Further study of factors associated with native kidney recovery after SLK is required. |
| doi_str_mv | 10.1097/TP.0b013e3182449161 |
| format | Article |
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The distance of a transplanted kidney from the renal scan camera can be substantially different from that of native kidneys. We developed a technique to correct attenuation of counts of all three kidneys based on their depth.
In our series of 13 SLK recipients, attenuation correction increased the measured renal function of native kidneys by up to 40%, demonstrating the importance of this procedure for accurately measuring kidney function. Eight patients met the United Network for Organ Sharing (UNOS)-proposed criteria for receiving a SLK, but four of these still had significant native kidney function (>40% of total function) after transplant. Five patients did not meet the UNOS-proposed criteria for SLK, yet only one of these had native kidney function recovery.
The criteria proposed by UNOS to determine that SLK is indicated, and thus that native kidney recovery is not expected, are not always accurate. Further study of factors associated with native kidney recovery after SLK is required.</description><identifier>ISSN: 0041-1337</identifier><identifier>EISSN: 1534-6080</identifier><identifier>DOI: 10.1097/TP.0b013e3182449161</identifier><identifier>PMID: 22245875</identifier><identifier>CODEN: TRPLAU</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Boston ; Cameras ; Female ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Humans ; Kidney - diagnostic imaging ; Kidney - physiopathology ; Kidney - surgery ; Kidney transplantation ; Kidney Transplantation - adverse effects ; Liver transplantation ; Liver Transplantation - adverse effects ; Liver, biliary tract, pancreas, portal circulation, spleen ; Male ; Medical sciences ; Middle Aged ; Multimodal Imaging ; Patient Selection ; Positron-Emission Tomography ; Practice Guidelines as Topic ; Predictive Value of Tests ; Radiopharmaceuticals ; Recovery of Function ; Renal function ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the digestive system ; Surgery of the urinary system ; Time Factors ; Tissue, organ and graft immunology ; Tomography, X-Ray Computed ; Treatment Outcome</subject><ispartof>Transplantation, 2012-03, Vol.93 (5), p.530-535</ispartof><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-2b6ea4f4d1e4270e35f6b732656d18bdbc3ecfb8d9c62f16cfb5146f231b53d13</citedby><cites>FETCH-LOGICAL-c412t-2b6ea4f4d1e4270e35f6b732656d18bdbc3ecfb8d9c62f16cfb5146f231b53d13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25703978$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22245875$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>FRANCIS, Jean M</creatorcontrib><creatorcontrib>PALMER, Matthew R</creatorcontrib><creatorcontrib>DONOHOE, Kevin</creatorcontrib><creatorcontrib>CURRY, Michael</creatorcontrib><creatorcontrib>JOHNSON, Scott R</creatorcontrib><creatorcontrib>KARP, Seth J</creatorcontrib><creatorcontrib>EVENSON, Amy R</creatorcontrib><creatorcontrib>PAVLAKIS, Martha</creatorcontrib><creatorcontrib>HANTO, Douglas W</creatorcontrib><creatorcontrib>MANDELBROT, Didier A</creatorcontrib><title>Evaluation of Native Kidney Recovery After Simultaneous Liver-Kidney Transplantation</title><title>Transplantation</title><addtitle>Transplantation</addtitle><description>Debate continues about which liver transplantation candidates with impaired renal function should undergo liver transplant alone versus simultaneous liver-kidney transplantation (SLK). Identifying predictors of native kidney function recovery after SLK requires an accurate measure of the relative function of all three kidneys in patients with SLK.
The distance of a transplanted kidney from the renal scan camera can be substantially different from that of native kidneys. We developed a technique to correct attenuation of counts of all three kidneys based on their depth.
In our series of 13 SLK recipients, attenuation correction increased the measured renal function of native kidneys by up to 40%, demonstrating the importance of this procedure for accurately measuring kidney function. Eight patients met the United Network for Organ Sharing (UNOS)-proposed criteria for receiving a SLK, but four of these still had significant native kidney function (>40% of total function) after transplant. Five patients did not meet the UNOS-proposed criteria for SLK, yet only one of these had native kidney function recovery.
The criteria proposed by UNOS to determine that SLK is indicated, and thus that native kidney recovery is not expected, are not always accurate. Further study of factors associated with native kidney recovery after SLK is required.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Boston</subject><subject>Cameras</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Humans</subject><subject>Kidney - diagnostic imaging</subject><subject>Kidney - physiopathology</subject><subject>Kidney - surgery</subject><subject>Kidney transplantation</subject><subject>Kidney Transplantation - adverse effects</subject><subject>Liver transplantation</subject><subject>Liver Transplantation - adverse effects</subject><subject>Liver, biliary tract, pancreas, portal circulation, spleen</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multimodal Imaging</subject><subject>Patient Selection</subject><subject>Positron-Emission Tomography</subject><subject>Practice Guidelines as Topic</subject><subject>Predictive Value of Tests</subject><subject>Radiopharmaceuticals</subject><subject>Recovery of Function</subject><subject>Renal function</subject><subject>Retrospective Studies</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the digestive system</subject><subject>Surgery of the urinary system</subject><subject>Time Factors</subject><subject>Tissue, organ and graft immunology</subject><subject>Tomography, X-Ray Computed</subject><subject>Treatment Outcome</subject><issn>0041-1337</issn><issn>1534-6080</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90EtLxDAQB_Agiq6PTyBIL6KXaiaTR3sU8YWLitZzSdMEKt12TdqF_fZGd1Xw4Gnm8JsHf0IOgZ4BzdV58XRGKwpoETLGeQ4SNsgEBPJU0oxukgmlHFJAVDtkN4Q3SqlApbbJDmOMi0yJCSmuFrod9dD0XdK75CF2C5vcN3Vnl8mzNf3C-mVy4Qbrk5dmNraD7mw_hmQanU_XsPC6C_NWd8PXpn2y5XQb7MG67pHX66vi8jadPt7cXV5MU8OBDSmrpNXc8RosZ4paFE5WCpkUsoasqiuD1rgqq3MjmQMZewFcOoZQCawB98jJau_c9--jDUM5a4Kxbbv6scwZChWTwShP_5VAaZahVMgjxRU1vg_BW1fOfTPTfhlR-Rl8WTyVf4OPU0frA2M1s_XPzHfSERyvgQ5Gty4mZprw64SimKsMPwAuCowh</recordid><startdate>20120315</startdate><enddate>20120315</enddate><creator>FRANCIS, Jean M</creator><creator>PALMER, Matthew R</creator><creator>DONOHOE, Kevin</creator><creator>CURRY, Michael</creator><creator>JOHNSON, Scott R</creator><creator>KARP, Seth J</creator><creator>EVENSON, Amy R</creator><creator>PAVLAKIS, Martha</creator><creator>HANTO, Douglas W</creator><creator>MANDELBROT, Didier A</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20120315</creationdate><title>Evaluation of Native Kidney Recovery After Simultaneous Liver-Kidney Transplantation</title><author>FRANCIS, Jean M ; PALMER, Matthew R ; DONOHOE, Kevin ; CURRY, Michael ; JOHNSON, Scott R ; KARP, Seth J ; EVENSON, Amy R ; PAVLAKIS, Martha ; HANTO, Douglas W ; MANDELBROT, Didier A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-2b6ea4f4d1e4270e35f6b732656d18bdbc3ecfb8d9c62f16cfb5146f231b53d13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Boston</topic><topic>Cameras</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Humans</topic><topic>Kidney - diagnostic imaging</topic><topic>Kidney - physiopathology</topic><topic>Kidney - surgery</topic><topic>Kidney transplantation</topic><topic>Kidney Transplantation - adverse effects</topic><topic>Liver transplantation</topic><topic>Liver Transplantation - adverse effects</topic><topic>Liver, biliary tract, pancreas, portal circulation, spleen</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multimodal Imaging</topic><topic>Patient Selection</topic><topic>Positron-Emission Tomography</topic><topic>Practice Guidelines as Topic</topic><topic>Predictive Value of Tests</topic><topic>Radiopharmaceuticals</topic><topic>Recovery of Function</topic><topic>Renal function</topic><topic>Retrospective Studies</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the digestive system</topic><topic>Surgery of the urinary system</topic><topic>Time Factors</topic><topic>Tissue, organ and graft immunology</topic><topic>Tomography, X-Ray Computed</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>FRANCIS, Jean M</creatorcontrib><creatorcontrib>PALMER, Matthew R</creatorcontrib><creatorcontrib>DONOHOE, Kevin</creatorcontrib><creatorcontrib>CURRY, Michael</creatorcontrib><creatorcontrib>JOHNSON, Scott R</creatorcontrib><creatorcontrib>KARP, Seth J</creatorcontrib><creatorcontrib>EVENSON, Amy R</creatorcontrib><creatorcontrib>PAVLAKIS, Martha</creatorcontrib><creatorcontrib>HANTO, Douglas W</creatorcontrib><creatorcontrib>MANDELBROT, Didier A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>FRANCIS, Jean M</au><au>PALMER, Matthew R</au><au>DONOHOE, Kevin</au><au>CURRY, Michael</au><au>JOHNSON, Scott R</au><au>KARP, Seth J</au><au>EVENSON, Amy R</au><au>PAVLAKIS, Martha</au><au>HANTO, Douglas W</au><au>MANDELBROT, Didier A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of Native Kidney Recovery After Simultaneous Liver-Kidney Transplantation</atitle><jtitle>Transplantation</jtitle><addtitle>Transplantation</addtitle><date>2012-03-15</date><risdate>2012</risdate><volume>93</volume><issue>5</issue><spage>530</spage><epage>535</epage><pages>530-535</pages><issn>0041-1337</issn><eissn>1534-6080</eissn><coden>TRPLAU</coden><abstract>Debate continues about which liver transplantation candidates with impaired renal function should undergo liver transplant alone versus simultaneous liver-kidney transplantation (SLK). Identifying predictors of native kidney function recovery after SLK requires an accurate measure of the relative function of all three kidneys in patients with SLK.
The distance of a transplanted kidney from the renal scan camera can be substantially different from that of native kidneys. We developed a technique to correct attenuation of counts of all three kidneys based on their depth.
In our series of 13 SLK recipients, attenuation correction increased the measured renal function of native kidneys by up to 40%, demonstrating the importance of this procedure for accurately measuring kidney function. Eight patients met the United Network for Organ Sharing (UNOS)-proposed criteria for receiving a SLK, but four of these still had significant native kidney function (>40% of total function) after transplant. Five patients did not meet the UNOS-proposed criteria for SLK, yet only one of these had native kidney function recovery.
The criteria proposed by UNOS to determine that SLK is indicated, and thus that native kidney recovery is not expected, are not always accurate. Further study of factors associated with native kidney recovery after SLK is required.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>22245875</pmid><doi>10.1097/TP.0b013e3182449161</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Transplantation, 2012-03, Vol.93 (5), p.530-535 |
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| subjects | Adult Aged Biological and medical sciences Boston Cameras Female Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Kidney - diagnostic imaging Kidney - physiopathology Kidney - surgery Kidney transplantation Kidney Transplantation - adverse effects Liver transplantation Liver Transplantation - adverse effects Liver, biliary tract, pancreas, portal circulation, spleen Male Medical sciences Middle Aged Multimodal Imaging Patient Selection Positron-Emission Tomography Practice Guidelines as Topic Predictive Value of Tests Radiopharmaceuticals Recovery of Function Renal function Retrospective Studies Risk Assessment Risk Factors Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the digestive system Surgery of the urinary system Time Factors Tissue, organ and graft immunology Tomography, X-Ray Computed Treatment Outcome |
| title | Evaluation of Native Kidney Recovery After Simultaneous Liver-Kidney Transplantation |
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