Protective role of antidiabetic drug metformin against gentamicin induced apoptosis in auditory cell line

Besides their prominent function in cellular energy metabolism, the central role of mitochondria has been focused on control of cellular death in last decades. The mitochondrial permeability transition pore (PTP) is involved in the intrinsic pathway of apoptosis via the release of cytochrome c into...

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Veröffentlicht in:	Hearing research 2011-12, Vol.282 (1), p.92-96
Hauptverfasser:	Jung, Hak Hyun, Chang, Jiwon, Yang, Ji Yoon, Choi, June, Im, Gi Jung, Chae, Sung Won
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Biological and medical sciences Blotting, Western Calcium - metabolism Caspase 3 - metabolism Cell Line Cell Survival - drug effects Cytoprotection Drug toxicity and drugs side effects treatment Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology Gentamicins - toxicity Hypoglycemic Agents - pharmacology Medical sciences Metformin - pharmacology Mice Molecular Imaging Non tumoral diseases Organ of Corti - drug effects Organ of Corti - metabolism Organ of Corti - pathology Otorhinolaryngology. Stomatology Pharmacology. Drug treatments Poly(ADP-ribose) Polymerases - metabolism Reactive Oxygen Species - metabolism Toxicity: respiratory system, ent, stomatology
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