d-methionine ( d-met) significantly rescues noise-induced hearing loss: Timing studies
We have previously reported rescue from noise-induced auditory brainstem response (ABR) threshold shifts with d-methionine ( d-met) administration 1 h after noise exposure. The present study investigated further d-met rescue intervals at 3, 5 and 7 h post-noise exposure. Chinchillas laniger were exp...
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| Veröffentlicht in: | Hearing research 2011-12, Vol.282 (1), p.138-144 |
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| creator | Campbell, Kathleen Claussen, Alex Meech, Robert Verhulst, Steven Fox, Daniel Hughes, Larry |
| description | We have previously reported rescue from noise-induced auditory brainstem response (ABR) threshold shifts with
d-methionine (
d-met) administration 1 h after noise exposure. The present study investigated further
d-met rescue intervals at 3, 5 and 7 h post-noise exposure.
Chinchillas laniger were exposed to a 6 h 105 dB sound pressure level (dB SPL) octave band noise (OBN) and then administered
d-met i.p. starting 3, 5, or 7 h after noise exposure; controls received saline i.p. immediately after noise exposure. ABR assessments were performed at baseline and on post-exposure days 1 and 21. Outer hair cell (OHC) loss was measured in cochleae obtained at sacrifice 21 days post-exposure. Administration of
d-met starting at any of the delay times of 3–7 h post-noise exposure significantly reduced day 21 ABR threshold shift at 2 and 4 kHz and OHC loss at all hair cell regions measured (2, 4, 6 and 8 kHz). ABR threshold shifts in the control group at 6 and 8 kHz were only 8 and 11 dB respectively allowing little opportunity to observe protection at those 2 frequencies.
[Display omitted]
► D-met provides consistent, significant rescue from noise-induced hearing loss (PTS). ► Rescue is significant even if D-met is delayed up to 7 hours after noise exposure. ► D-met rescue includes protection from ABR threshold shift and outer hair cell loss. ► Rescue from permanent, but not temporary, threshold shift is consistent in studies. ► We predict protection may be seen with epochs beyond 7 hours. |
| doi_str_mv | 10.1016/j.heares.2011.08.003 |
| format | Article |
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d-methionine (
d-met) administration 1 h after noise exposure. The present study investigated further
d-met rescue intervals at 3, 5 and 7 h post-noise exposure.
Chinchillas laniger were exposed to a 6 h 105 dB sound pressure level (dB SPL) octave band noise (OBN) and then administered
d-met i.p. starting 3, 5, or 7 h after noise exposure; controls received saline i.p. immediately after noise exposure. ABR assessments were performed at baseline and on post-exposure days 1 and 21. Outer hair cell (OHC) loss was measured in cochleae obtained at sacrifice 21 days post-exposure. Administration of
d-met starting at any of the delay times of 3–7 h post-noise exposure significantly reduced day 21 ABR threshold shift at 2 and 4 kHz and OHC loss at all hair cell regions measured (2, 4, 6 and 8 kHz). ABR threshold shifts in the control group at 6 and 8 kHz were only 8 and 11 dB respectively allowing little opportunity to observe protection at those 2 frequencies.
[Display omitted]
► D-met provides consistent, significant rescue from noise-induced hearing loss (PTS). ► Rescue is significant even if D-met is delayed up to 7 hours after noise exposure. ► D-met rescue includes protection from ABR threshold shift and outer hair cell loss. ► Rescue from permanent, but not temporary, threshold shift is consistent in studies. ► We predict protection may be seen with epochs beyond 7 hours.</description><identifier>ISSN: 0378-5955</identifier><identifier>EISSN: 1878-5891</identifier><identifier>DOI: 10.1016/j.heares.2011.08.003</identifier><identifier>PMID: 21924333</identifier><identifier>CODEN: HERED3</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Acoustic Stimulation ; Animals ; Biological and medical sciences ; Brain Stem - drug effects ; Brain Stem - pathology ; Brain Stem - physiopathology ; Chinchilla ; Cytoprotection ; Disease Models, Animal ; Drug Administration Schedule ; Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation ; Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology ; Evoked Potentials, Auditory, Brain Stem - drug effects ; Fundamental and applied biological sciences. Psychology ; Hair Cells, Auditory, Outer - drug effects ; Hair Cells, Auditory, Outer - pathology ; Hearing Loss, Noise-Induced - pathology ; Hearing Loss, Noise-Induced - physiopathology ; Hearing Loss, Noise-Induced - prevention & control ; Male ; Medical sciences ; Methionine - administration & dosage ; Non tumoral diseases ; Otorhinolaryngology. Stomatology ; Protective Agents - administration & dosage ; Rodentia ; Time Factors ; Vertebrates: nervous system and sense organs</subject><ispartof>Hearing research, 2011-12, Vol.282 (1), p.138-144</ispartof><rights>2011 Elsevier B.V.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c617t-d78f8bf0c6db52ec612cd662257d42991514fdf5e547dea95f0b239c3a2034eb3</citedby><cites>FETCH-LOGICAL-c617t-d78f8bf0c6db52ec612cd662257d42991514fdf5e547dea95f0b239c3a2034eb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.heares.2011.08.003$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25289914$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21924333$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Campbell, Kathleen</creatorcontrib><creatorcontrib>Claussen, Alex</creatorcontrib><creatorcontrib>Meech, Robert</creatorcontrib><creatorcontrib>Verhulst, Steven</creatorcontrib><creatorcontrib>Fox, Daniel</creatorcontrib><creatorcontrib>Hughes, Larry</creatorcontrib><title>d-methionine ( d-met) significantly rescues noise-induced hearing loss: Timing studies</title><title>Hearing research</title><addtitle>Hear Res</addtitle><description>We have previously reported rescue from noise-induced auditory brainstem response (ABR) threshold shifts with
d-methionine (
d-met) administration 1 h after noise exposure. The present study investigated further
d-met rescue intervals at 3, 5 and 7 h post-noise exposure.
Chinchillas laniger were exposed to a 6 h 105 dB sound pressure level (dB SPL) octave band noise (OBN) and then administered
d-met i.p. starting 3, 5, or 7 h after noise exposure; controls received saline i.p. immediately after noise exposure. ABR assessments were performed at baseline and on post-exposure days 1 and 21. Outer hair cell (OHC) loss was measured in cochleae obtained at sacrifice 21 days post-exposure. Administration of
d-met starting at any of the delay times of 3–7 h post-noise exposure significantly reduced day 21 ABR threshold shift at 2 and 4 kHz and OHC loss at all hair cell regions measured (2, 4, 6 and 8 kHz). ABR threshold shifts in the control group at 6 and 8 kHz were only 8 and 11 dB respectively allowing little opportunity to observe protection at those 2 frequencies.
[Display omitted]
► D-met provides consistent, significant rescue from noise-induced hearing loss (PTS). ► Rescue is significant even if D-met is delayed up to 7 hours after noise exposure. ► D-met rescue includes protection from ABR threshold shift and outer hair cell loss. ► Rescue from permanent, but not temporary, threshold shift is consistent in studies. ► We predict protection may be seen with epochs beyond 7 hours.</description><subject>Acoustic Stimulation</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain Stem - drug effects</subject><subject>Brain Stem - pathology</subject><subject>Brain Stem - physiopathology</subject><subject>Chinchilla</subject><subject>Cytoprotection</subject><subject>Disease Models, Animal</subject><subject>Drug Administration Schedule</subject><subject>Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation</subject><subject>Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology</subject><subject>Evoked Potentials, Auditory, Brain Stem - drug effects</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hair Cells, Auditory, Outer - drug effects</subject><subject>Hair Cells, Auditory, Outer - pathology</subject><subject>Hearing Loss, Noise-Induced - pathology</subject><subject>Hearing Loss, Noise-Induced - physiopathology</subject><subject>Hearing Loss, Noise-Induced - prevention & control</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Methionine - administration & dosage</subject><subject>Non tumoral diseases</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Protective Agents - administration & dosage</subject><subject>Rodentia</subject><subject>Time Factors</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0378-5955</issn><issn>1878-5891</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNks1u1TAQhS1ERS-FN0AoGwQsEsZ_id0FEqqAIlViU9hajj1pfZU4JU6Q-vZ1uBfYVVnZM_pmzkjnEPKKQkWB1h_21S3aCVPFgNIKVAXAn5AdVY0qpdL0KdkBX_9aylPyPKU9AJVcsGfklFHNBOd8R376csD5NowxRCzeFX_K90UKNzF0wdk49_dFVnELpiKOIWEZol8c-mKVD_Gm6MeUzovrMKxFmhcfML0gJ53tE748vmfkx5fP1xeX5dX3r98uPl2VrqbNXPpGdartwNW-lQxzkzlf14zJxgumNZVUdL6TKEXj0WrZQcu4dtwy4AJbfkbeHvbeTeOvfOJshpAc9r2NOC7JaMYZsKy1haRaN0JuIEFB1mdbyEZrUW_YSVl2RDYbdoJqBANQmRQH0k3ZgQk7czeFwU73hoJZI2L25hARs0bEgDI5Inns9VFgaQf0_4b-ZiIDb46ATc723WSjC-k_J5nKzojMfTxwmA3-HXAyyQWMORphQjcbP4bHL3kAZeXZbw</recordid><startdate>20111201</startdate><enddate>20111201</enddate><creator>Campbell, Kathleen</creator><creator>Claussen, Alex</creator><creator>Meech, Robert</creator><creator>Verhulst, Steven</creator><creator>Fox, Daniel</creator><creator>Hughes, Larry</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>20111201</creationdate><title>d-methionine ( d-met) significantly rescues noise-induced hearing loss: Timing studies</title><author>Campbell, Kathleen ; Claussen, Alex ; Meech, Robert ; Verhulst, Steven ; Fox, Daniel ; Hughes, Larry</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c617t-d78f8bf0c6db52ec612cd662257d42991514fdf5e547dea95f0b239c3a2034eb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Acoustic Stimulation</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Brain Stem - drug effects</topic><topic>Brain Stem - pathology</topic><topic>Brain Stem - physiopathology</topic><topic>Chinchilla</topic><topic>Cytoprotection</topic><topic>Disease Models, Animal</topic><topic>Drug Administration Schedule</topic><topic>Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation</topic><topic>Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology</topic><topic>Evoked Potentials, Auditory, Brain Stem - drug effects</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hair Cells, Auditory, Outer - drug effects</topic><topic>Hair Cells, Auditory, Outer - pathology</topic><topic>Hearing Loss, Noise-Induced - pathology</topic><topic>Hearing Loss, Noise-Induced - physiopathology</topic><topic>Hearing Loss, Noise-Induced - prevention & control</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Methionine - administration & dosage</topic><topic>Non tumoral diseases</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Protective Agents - administration & dosage</topic><topic>Rodentia</topic><topic>Time Factors</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Campbell, Kathleen</creatorcontrib><creatorcontrib>Claussen, Alex</creatorcontrib><creatorcontrib>Meech, Robert</creatorcontrib><creatorcontrib>Verhulst, Steven</creatorcontrib><creatorcontrib>Fox, Daniel</creatorcontrib><creatorcontrib>Hughes, Larry</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Hearing research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Campbell, Kathleen</au><au>Claussen, Alex</au><au>Meech, Robert</au><au>Verhulst, Steven</au><au>Fox, Daniel</au><au>Hughes, Larry</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>d-methionine ( d-met) significantly rescues noise-induced hearing loss: Timing studies</atitle><jtitle>Hearing research</jtitle><addtitle>Hear Res</addtitle><date>2011-12-01</date><risdate>2011</risdate><volume>282</volume><issue>1</issue><spage>138</spage><epage>144</epage><pages>138-144</pages><issn>0378-5955</issn><eissn>1878-5891</eissn><coden>HERED3</coden><abstract>We have previously reported rescue from noise-induced auditory brainstem response (ABR) threshold shifts with
d-methionine (
d-met) administration 1 h after noise exposure. The present study investigated further
d-met rescue intervals at 3, 5 and 7 h post-noise exposure.
Chinchillas laniger were exposed to a 6 h 105 dB sound pressure level (dB SPL) octave band noise (OBN) and then administered
d-met i.p. starting 3, 5, or 7 h after noise exposure; controls received saline i.p. immediately after noise exposure. ABR assessments were performed at baseline and on post-exposure days 1 and 21. Outer hair cell (OHC) loss was measured in cochleae obtained at sacrifice 21 days post-exposure. Administration of
d-met starting at any of the delay times of 3–7 h post-noise exposure significantly reduced day 21 ABR threshold shift at 2 and 4 kHz and OHC loss at all hair cell regions measured (2, 4, 6 and 8 kHz). ABR threshold shifts in the control group at 6 and 8 kHz were only 8 and 11 dB respectively allowing little opportunity to observe protection at those 2 frequencies.
[Display omitted]
► D-met provides consistent, significant rescue from noise-induced hearing loss (PTS). ► Rescue is significant even if D-met is delayed up to 7 hours after noise exposure. ► D-met rescue includes protection from ABR threshold shift and outer hair cell loss. ► Rescue from permanent, but not temporary, threshold shift is consistent in studies. ► We predict protection may be seen with epochs beyond 7 hours.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>21924333</pmid><doi>10.1016/j.heares.2011.08.003</doi><tpages>7</tpages></addata></record> |
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| subjects | Acoustic Stimulation Animals Biological and medical sciences Brain Stem - drug effects Brain Stem - pathology Brain Stem - physiopathology Chinchilla Cytoprotection Disease Models, Animal Drug Administration Schedule Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology Evoked Potentials, Auditory, Brain Stem - drug effects Fundamental and applied biological sciences. Psychology Hair Cells, Auditory, Outer - drug effects Hair Cells, Auditory, Outer - pathology Hearing Loss, Noise-Induced - pathology Hearing Loss, Noise-Induced - physiopathology Hearing Loss, Noise-Induced - prevention & control Male Medical sciences Methionine - administration & dosage Non tumoral diseases Otorhinolaryngology. Stomatology Protective Agents - administration & dosage Rodentia Time Factors Vertebrates: nervous system and sense organs |
| title | d-methionine ( d-met) significantly rescues noise-induced hearing loss: Timing studies |
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