Giant disseminated condylomatosis in SLE
Introduction: Females with systemic lupus erythematosus (SLE) have higher prevalence of human papillomavirus (HPV) infection, which can lead to the development of warts. Herein we report the first case of giant disseminated condylomatosis (GDC) in a SLE female on mycophenolate mofetil (MMF). Case re...
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| Veröffentlicht in: | Lupus 2012-03, Vol.21 (3), p.332-334 |
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| creator | CostaPinto, L Grassi, MFR Serravalle, K Travessa, ACV Olavarria, VNO Santiago, MB |
| description | Introduction: Females with systemic lupus erythematosus (SLE) have higher prevalence of human papillomavirus (HPV) infection, which can lead to the development of warts. Herein we report the first case of giant disseminated condylomatosis (GDC) in a SLE female on mycophenolate mofetil (MMF). Case report: The patient, a 33-year-old, Black female, was diagnosed with SLE during her first pregnancy in 2003 based on the features of arthritis, skin rash, seizures, nephritis and presence of antinuclear antibodies. Her pregnancy resulted in preterm delivery of a stillborn fetus at 28 weeks. Since that time she has been treated with steroids and different regimens of immunosuppressive drugs such as cyclophosphamide, azathioprine and lately MMF. In the last few years she presented GDC involving the genital area in addition to skin on the lower abdomen. Topical therapy with trichloroacetic acid, imiquimod and podophyllin was only partially effective. Different types of HPV were identified in the lesions, being HPV-11 in abdomen, HPV 6, 11, 42 in vulva, HPV-6, 11 in vagina and HPV-6, 11 in endocervix. Conclusions: GDC may be a complication of SLE, secondary to the disease itself, its treatment or other factors not yet identified. |
| doi_str_mv | 10.1177/0961203311421207 |
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Herein we report the first case of giant disseminated condylomatosis (GDC) in a SLE female on mycophenolate mofetil (MMF). Case report: The patient, a 33-year-old, Black female, was diagnosed with SLE during her first pregnancy in 2003 based on the features of arthritis, skin rash, seizures, nephritis and presence of antinuclear antibodies. Her pregnancy resulted in preterm delivery of a stillborn fetus at 28 weeks. Since that time she has been treated with steroids and different regimens of immunosuppressive drugs such as cyclophosphamide, azathioprine and lately MMF. In the last few years she presented GDC involving the genital area in addition to skin on the lower abdomen. Topical therapy with trichloroacetic acid, imiquimod and podophyllin was only partially effective. Different types of HPV were identified in the lesions, being HPV-11 in abdomen, HPV 6, 11, 42 in vulva, HPV-6, 11 in vagina and HPV-6, 11 in endocervix. Conclusions: GDC may be a complication of SLE, secondary to the disease itself, its treatment or other factors not yet identified.</description><identifier>ISSN: 0961-2033</identifier><identifier>EISSN: 1477-0962</identifier><identifier>DOI: 10.1177/0961203311421207</identifier><identifier>PMID: 21965277</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Abdomen ; Acids ; Adult ; Aminoquinolines - administration & dosage ; Aminoquinolines - therapeutic use ; Arthritis ; Biopsy ; Case reports ; Cellular biology ; Condylomata Acuminata - drug therapy ; Condylomata Acuminata - etiology ; Condylomata Acuminata - virology ; Disease ; Drug Therapy, Combination ; Drugs ; Female ; Females ; Fetuses ; Human papillomavirus ; Humans ; Immunosuppressive agents ; Immunosuppressive Agents - therapeutic use ; Infections ; Lupus ; Lupus Erythematosus, Systemic - complications ; Lupus Erythematosus, Systemic - drug therapy ; Mycophenolic Acid - analogs & derivatives ; Mycophenolic Acid - therapeutic use ; Papillomaviridae - classification ; Papillomaviridae - isolation & purification ; Patients ; Podophyllin - administration & dosage ; Podophyllin - therapeutic use ; Pregnancy ; Treatment Outcome ; Trichloroacetic Acid - administration & dosage ; Trichloroacetic Acid - therapeutic use ; Vagina ; Warts</subject><ispartof>Lupus, 2012-03, Vol.21 (3), p.332-334</ispartof><rights>The Author(s), 2012. 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Herein we report the first case of giant disseminated condylomatosis (GDC) in a SLE female on mycophenolate mofetil (MMF). Case report: The patient, a 33-year-old, Black female, was diagnosed with SLE during her first pregnancy in 2003 based on the features of arthritis, skin rash, seizures, nephritis and presence of antinuclear antibodies. Her pregnancy resulted in preterm delivery of a stillborn fetus at 28 weeks. Since that time she has been treated with steroids and different regimens of immunosuppressive drugs such as cyclophosphamide, azathioprine and lately MMF. In the last few years she presented GDC involving the genital area in addition to skin on the lower abdomen. Topical therapy with trichloroacetic acid, imiquimod and podophyllin was only partially effective. Different types of HPV were identified in the lesions, being HPV-11 in abdomen, HPV 6, 11, 42 in vulva, HPV-6, 11 in vagina and HPV-6, 11 in endocervix. Conclusions: GDC may be a complication of SLE, secondary to the disease itself, its treatment or other factors not yet identified.</description><subject>Abdomen</subject><subject>Acids</subject><subject>Adult</subject><subject>Aminoquinolines - administration & dosage</subject><subject>Aminoquinolines - therapeutic use</subject><subject>Arthritis</subject><subject>Biopsy</subject><subject>Case reports</subject><subject>Cellular biology</subject><subject>Condylomata Acuminata - drug therapy</subject><subject>Condylomata Acuminata - etiology</subject><subject>Condylomata Acuminata - virology</subject><subject>Disease</subject><subject>Drug Therapy, Combination</subject><subject>Drugs</subject><subject>Female</subject><subject>Females</subject><subject>Fetuses</subject><subject>Human papillomavirus</subject><subject>Humans</subject><subject>Immunosuppressive agents</subject><subject>Immunosuppressive Agents - therapeutic use</subject><subject>Infections</subject><subject>Lupus</subject><subject>Lupus Erythematosus, Systemic - complications</subject><subject>Lupus Erythematosus, Systemic - drug therapy</subject><subject>Mycophenolic Acid - analogs & derivatives</subject><subject>Mycophenolic Acid - therapeutic use</subject><subject>Papillomaviridae - classification</subject><subject>Papillomaviridae - isolation & purification</subject><subject>Patients</subject><subject>Podophyllin - administration & dosage</subject><subject>Podophyllin - therapeutic use</subject><subject>Pregnancy</subject><subject>Treatment Outcome</subject><subject>Trichloroacetic Acid - administration & dosage</subject><subject>Trichloroacetic Acid - therapeutic use</subject><subject>Vagina</subject><subject>Warts</subject><issn>0961-2033</issn><issn>1477-0962</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkEFPwzAMhSMEYmNw54QqLnAp2EnbNEc0jYE0iQNwrtImQZnaZjTtYf9-GRsgTULiZMv-_Gw_Qi4R7hA5vweRIQXGEBMaEn5ExphwHoc6PSbjbTve9kfkzPslADAU2SkZ0RBSyvmY3M6tbPtIWe91Y1vZaxVVrlXr2jWyd976yLbR62J2Tk6MrL2-2McJeX-cvU2f4sXL_Hn6sIirhPE-ThmTgEagxlJzZlAKRVWZlShzw_NwJGTGcMxMiqrSHHSuEpBfX5SGSTYhNzvdVec-B-37orG-0nUtW-0GXwjKgkbC0n-QQGmeMxrI6wNy6YauDW8UAoUQIPIkQLCDqs5532lTrDrbyG5dIBRbt4tDt8PI1V53KButfga-7Q1AvAO8_NC_S_8U3ADWOoOm</recordid><startdate>201203</startdate><enddate>201203</enddate><creator>CostaPinto, L</creator><creator>Grassi, MFR</creator><creator>Serravalle, K</creator><creator>Travessa, ACV</creator><creator>Olavarria, VNO</creator><creator>Santiago, MB</creator><general>SAGE Publications</general><general>Sage Publications Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9-</scope><scope>K9.</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>201203</creationdate><title>Giant disseminated condylomatosis in SLE</title><author>CostaPinto, L ; Grassi, MFR ; Serravalle, K ; Travessa, ACV ; Olavarria, VNO ; Santiago, MB</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c437t-533a01f91e1be73f1a9d2db6b1a8f7812006ff716f51dce70e8d40a12033bf3a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Abdomen</topic><topic>Acids</topic><topic>Adult</topic><topic>Aminoquinolines - administration & dosage</topic><topic>Aminoquinolines - therapeutic use</topic><topic>Arthritis</topic><topic>Biopsy</topic><topic>Case reports</topic><topic>Cellular biology</topic><topic>Condylomata Acuminata - drug therapy</topic><topic>Condylomata Acuminata - etiology</topic><topic>Condylomata Acuminata - virology</topic><topic>Disease</topic><topic>Drug Therapy, Combination</topic><topic>Drugs</topic><topic>Female</topic><topic>Females</topic><topic>Fetuses</topic><topic>Human papillomavirus</topic><topic>Humans</topic><topic>Immunosuppressive agents</topic><topic>Immunosuppressive Agents - therapeutic use</topic><topic>Infections</topic><topic>Lupus</topic><topic>Lupus Erythematosus, Systemic - complications</topic><topic>Lupus Erythematosus, Systemic - drug therapy</topic><topic>Mycophenolic Acid - analogs & derivatives</topic><topic>Mycophenolic Acid - therapeutic use</topic><topic>Papillomaviridae - classification</topic><topic>Papillomaviridae - isolation & purification</topic><topic>Patients</topic><topic>Podophyllin - administration & dosage</topic><topic>Podophyllin - therapeutic use</topic><topic>Pregnancy</topic><topic>Treatment Outcome</topic><topic>Trichloroacetic Acid - administration & dosage</topic><topic>Trichloroacetic Acid - therapeutic use</topic><topic>Vagina</topic><topic>Warts</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CostaPinto, L</creatorcontrib><creatorcontrib>Grassi, MFR</creatorcontrib><creatorcontrib>Serravalle, K</creatorcontrib><creatorcontrib>Travessa, ACV</creatorcontrib><creatorcontrib>Olavarria, VNO</creatorcontrib><creatorcontrib>Santiago, MB</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Lupus</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CostaPinto, L</au><au>Grassi, MFR</au><au>Serravalle, K</au><au>Travessa, ACV</au><au>Olavarria, VNO</au><au>Santiago, MB</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Giant disseminated condylomatosis in SLE</atitle><jtitle>Lupus</jtitle><addtitle>Lupus</addtitle><date>2012-03</date><risdate>2012</risdate><volume>21</volume><issue>3</issue><spage>332</spage><epage>334</epage><pages>332-334</pages><issn>0961-2033</issn><eissn>1477-0962</eissn><abstract>Introduction: Females with systemic lupus erythematosus (SLE) have higher prevalence of human papillomavirus (HPV) infection, which can lead to the development of warts. Herein we report the first case of giant disseminated condylomatosis (GDC) in a SLE female on mycophenolate mofetil (MMF). Case report: The patient, a 33-year-old, Black female, was diagnosed with SLE during her first pregnancy in 2003 based on the features of arthritis, skin rash, seizures, nephritis and presence of antinuclear antibodies. Her pregnancy resulted in preterm delivery of a stillborn fetus at 28 weeks. Since that time she has been treated with steroids and different regimens of immunosuppressive drugs such as cyclophosphamide, azathioprine and lately MMF. In the last few years she presented GDC involving the genital area in addition to skin on the lower abdomen. Topical therapy with trichloroacetic acid, imiquimod and podophyllin was only partially effective. Different types of HPV were identified in the lesions, being HPV-11 in abdomen, HPV 6, 11, 42 in vulva, HPV-6, 11 in vagina and HPV-6, 11 in endocervix. Conclusions: GDC may be a complication of SLE, secondary to the disease itself, its treatment or other factors not yet identified.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>21965277</pmid><doi>10.1177/0961203311421207</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; SAGE Complete |
| subjects | Abdomen Acids Adult Aminoquinolines - administration & dosage Aminoquinolines - therapeutic use Arthritis Biopsy Case reports Cellular biology Condylomata Acuminata - drug therapy Condylomata Acuminata - etiology Condylomata Acuminata - virology Disease Drug Therapy, Combination Drugs Female Females Fetuses Human papillomavirus Humans Immunosuppressive agents Immunosuppressive Agents - therapeutic use Infections Lupus Lupus Erythematosus, Systemic - complications Lupus Erythematosus, Systemic - drug therapy Mycophenolic Acid - analogs & derivatives Mycophenolic Acid - therapeutic use Papillomaviridae - classification Papillomaviridae - isolation & purification Patients Podophyllin - administration & dosage Podophyllin - therapeutic use Pregnancy Treatment Outcome Trichloroacetic Acid - administration & dosage Trichloroacetic Acid - therapeutic use Vagina Warts |
| title | Giant disseminated condylomatosis in SLE |
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