Semisynthetic neoboutomellerone derivatives as ubiquitin-proteasome pathway inhibitors

Structures of neoboutomellerones isolated from Neoboutonia melleri. The interesting pharmacological properties of neoboutomellerones 1 and 2 were the basis for the assembly of a small library of analogues consisting of natural products isolated from the plant Neoboutonia melleri and of semisynthetic...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2012-01, Vol.20 (2), p.819-831
Hauptverfasser:	Beck, Joséphine, Guminski, Yves, Long, Christophe, Marcourt, Laurence, Derguini, Fadila, Plisson, Fabien, Grondin, Antonio, Vandenberghe, Isabelle, Vispé, Stéphane, Brel, Viviane, Aussagues, Yannick, Ausseil, Frédéric, Arimondo, Paola B., Massiot, Georges, Sautel, François, Cantagrel, Frédéric
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer agent antineoplastic agents Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - toxicity Biological Products - chemistry Cell Line, Tumor Cycloartane Euphorbiaceae - chemistry Humans mechanism of action melanoma Natural product Neoboutonia melleri Proteasome proteasome endopeptidase complex Proteasome Endopeptidase Complex - metabolism Proteasome Inhibitors Signal Transduction - drug effects synthetic products Triterpenes - chemical synthesis Triterpenes - chemistry Triterpenes - toxicity Ubiquitin - antagonists & inhibitors Ubiquitin - metabolism
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