Psychoactive Medications and Crash Involvement Requiring Hospitalization for Older Drivers: A Population-Based Study
OBJECTIVES: To determine the association between psychoactive medications and crash risk in drivers aged 60 and older. DESIGN: Retrospective population‐based case‐crossover study. SETTING: A database study that linked the Western Australian Hospital Morbidity Data System and the Pharmaceutical Benef...
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| Veröffentlicht in: | Journal of the American Geriatrics Society (JAGS) 2011-09, Vol.59 (9), p.1575-1580 |
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| container_title | Journal of the American Geriatrics Society (JAGS) |
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| creator | Meuleners, Lynn B. Duke, Janine Lee, Andy H. Palamara, Peter Hildebrand, Janina Ng, Jonathon Q. |
| description | OBJECTIVES: To determine the association between psychoactive medications and crash risk in drivers aged 60 and older.
DESIGN: Retrospective population‐based case‐crossover study.
SETTING: A database study that linked the Western Australian Hospital Morbidity Data System and the Pharmaceutical Benefits Scheme.
PARTICIPANTS: Six hundred sixteen individuals aged 60 and older who were hospitalized as the result of a motor vehicle crash between 2002 and 2008 in Western Australia.
MEASUREMENTS: Hospitalization after a motor vehicle crash.
RESULTS: Greater risk for a hospitalization crash was found for older drivers prescribed benzodiazepines (odds ratio (OR)=5.3, 95% confidence interval (CI)=3.6–7.8, P |
| doi_str_mv | 10.1111/j.1532-5415.2011.03561.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_923198139</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>908741821</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5611-680f75a7b756a566f90f835e78e0c2894f684a239aea624c7d2887b0fed3cfa53</originalsourceid><addsrcrecordid>eNqNkV1v0zAUhi0EYmXwF5CFhLhK8EccO0hcjMK6oY0Nxpe4sVzHZu7SuLOT0vLrcdpSJG7AN8fSed6jc_QAADHKcXrPZzlmlGSswCwnCOMcUVbifHUHjPaNu2CEECKZKHFxAB7EOEMIEyTEfXBAsBAUYzQC3WVc62uvdOeWBp6b2mnVOd9GqNoajoOK1_C0Xfpmaeam7eAHc9u74Nrv8MTHhetU435uAtD6AC-a2gT4OqRZIb6AR_DSL_pm089eqWhqeNX19fohuGdVE82jXT0En47ffByfZGcXk9Px0Vmm0zU4KwWynCk-5axUrCxthaygzHBhkCaiKmwpCkVopYwqSaF5TYTgU2RNTbVVjB6CZ9u5i-BvexM7OXdRm6ZRrfF9lBWhuBKYVv8mkeAFFgQn8slf5Mz3oU1nyLSRKAqGeILEFtLBxxiMlYvg5iqsJUZyMChnchAlB1FyMCg3BuUqRR_v5vfTuan3wd_KEvB0B6ioVWODarWLf7iCccYISdzLLffDNWb93wvIt5Or4Zfy2TbvYmdW-7wKN7LklDP55d1EsnP-_hs__iy_0l-wNMW_</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>894844507</pqid></control><display><type>article</type><title>Psychoactive Medications and Crash Involvement Requiring Hospitalization for Older Drivers: A Population-Based Study</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Meuleners, Lynn B. ; Duke, Janine ; Lee, Andy H. ; Palamara, Peter ; Hildebrand, Janina ; Ng, Jonathon Q.</creator><creatorcontrib>Meuleners, Lynn B. ; Duke, Janine ; Lee, Andy H. ; Palamara, Peter ; Hildebrand, Janina ; Ng, Jonathon Q.</creatorcontrib><description>OBJECTIVES: To determine the association between psychoactive medications and crash risk in drivers aged 60 and older.
DESIGN: Retrospective population‐based case‐crossover study.
SETTING: A database study that linked the Western Australian Hospital Morbidity Data System and the Pharmaceutical Benefits Scheme.
PARTICIPANTS: Six hundred sixteen individuals aged 60 and older who were hospitalized as the result of a motor vehicle crash between 2002 and 2008 in Western Australia.
MEASUREMENTS: Hospitalization after a motor vehicle crash.
RESULTS: Greater risk for a hospitalization crash was found for older drivers prescribed benzodiazepines (odds ratio (OR)=5.3, 95% confidence interval (CI)=3.6–7.8, P<.001), antidepressants (OR=1.8, 95% CI=1.0–3.3, P=.04), and opioid analgesics (OR=1.5, 95% CI=1.0–2.3, P=.05). Crash risk was significantly greater in men prescribed a benzodiazepine (OR=6.2, 95% CI=3.2–12.2, P<.001) or an antidepressant (OR=2.7, 95% CI=1.1–6.9, P=.03). Women prescribed benzodiazepines (OR=4.9, 95% CI=3.1–7.8, P<.001) or opioid analgesics (OR=1.8, 95% CI=1.1–3.0, P=.03) also had a significantly greater crash risk. Subgroup analyses further suggested that drivers with (OR=4.0, 95% CI=2.9–8.1, P<.001) and without (OR=6.0, 95% CI=3.8–9.5, P<.001) a chronic condition who were prescribed benzodiazepines were at greater crash risk. Drivers with a chronic condition taking antidepressants (OR=3.4, 95% CI=1.3–8.5, P=.01) also had a greater crash risk.
CONCLUSION: Psychoactive medication usage was associated with greater risk of a motor vehicle crash requiring hospitalization in older drivers.</description><identifier>ISSN: 0002-8614</identifier><identifier>EISSN: 1532-5415</identifier><identifier>DOI: 10.1111/j.1532-5415.2011.03561.x</identifier><identifier>PMID: 21883110</identifier><identifier>CODEN: JAGSAF</identifier><language>eng</language><publisher>Malden, USA: Blackwell Publishing Inc</publisher><subject>Accidents ; Accidents, Traffic - statistics & numerical data ; Aged ; Aged, 80 and over ; Analgesics, Opioid - adverse effects ; antidepressants ; Antidepressive Agents ; Automobile drivers ; Automobile Driving ; Benzodiazepines - adverse effects ; Biological and medical sciences ; Chronic Disease - epidemiology ; crash risk ; Cross-Over Studies ; Databases, Factual ; Drugs ; Female ; General aspects ; Hospitalization - statistics & numerical data ; Hospitals ; Humans ; Male ; Medical sciences ; Middle Aged ; Miscellaneous ; Morbidity ; older drivers ; Older people ; psychoactive medications ; Psychotropic drugs ; Psychotropic Drugs - adverse effects ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Retrospective Studies ; Risk Factors ; Traffic accidents & safety ; Western Australia - epidemiology</subject><ispartof>Journal of the American Geriatrics Society (JAGS), 2011-09, Vol.59 (9), p.1575-1580</ispartof><rights>2011, Copyright the Authors. Journal compilation © 2011, The American Geriatrics Society</rights><rights>2015 INIST-CNRS</rights><rights>2011, Copyright the Authors. Journal compilation © 2011, The American Geriatrics Society.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5611-680f75a7b756a566f90f835e78e0c2894f684a239aea624c7d2887b0fed3cfa53</citedby><cites>FETCH-LOGICAL-c5611-680f75a7b756a566f90f835e78e0c2894f684a239aea624c7d2887b0fed3cfa53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1532-5415.2011.03561.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1532-5415.2011.03561.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24575522$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21883110$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Meuleners, Lynn B.</creatorcontrib><creatorcontrib>Duke, Janine</creatorcontrib><creatorcontrib>Lee, Andy H.</creatorcontrib><creatorcontrib>Palamara, Peter</creatorcontrib><creatorcontrib>Hildebrand, Janina</creatorcontrib><creatorcontrib>Ng, Jonathon Q.</creatorcontrib><title>Psychoactive Medications and Crash Involvement Requiring Hospitalization for Older Drivers: A Population-Based Study</title><title>Journal of the American Geriatrics Society (JAGS)</title><addtitle>J Am Geriatr Soc</addtitle><description>OBJECTIVES: To determine the association between psychoactive medications and crash risk in drivers aged 60 and older.
DESIGN: Retrospective population‐based case‐crossover study.
SETTING: A database study that linked the Western Australian Hospital Morbidity Data System and the Pharmaceutical Benefits Scheme.
PARTICIPANTS: Six hundred sixteen individuals aged 60 and older who were hospitalized as the result of a motor vehicle crash between 2002 and 2008 in Western Australia.
MEASUREMENTS: Hospitalization after a motor vehicle crash.
RESULTS: Greater risk for a hospitalization crash was found for older drivers prescribed benzodiazepines (odds ratio (OR)=5.3, 95% confidence interval (CI)=3.6–7.8, P<.001), antidepressants (OR=1.8, 95% CI=1.0–3.3, P=.04), and opioid analgesics (OR=1.5, 95% CI=1.0–2.3, P=.05). Crash risk was significantly greater in men prescribed a benzodiazepine (OR=6.2, 95% CI=3.2–12.2, P<.001) or an antidepressant (OR=2.7, 95% CI=1.1–6.9, P=.03). Women prescribed benzodiazepines (OR=4.9, 95% CI=3.1–7.8, P<.001) or opioid analgesics (OR=1.8, 95% CI=1.1–3.0, P=.03) also had a significantly greater crash risk. Subgroup analyses further suggested that drivers with (OR=4.0, 95% CI=2.9–8.1, P<.001) and without (OR=6.0, 95% CI=3.8–9.5, P<.001) a chronic condition who were prescribed benzodiazepines were at greater crash risk. Drivers with a chronic condition taking antidepressants (OR=3.4, 95% CI=1.3–8.5, P=.01) also had a greater crash risk.
CONCLUSION: Psychoactive medication usage was associated with greater risk of a motor vehicle crash requiring hospitalization in older drivers.</description><subject>Accidents</subject><subject>Accidents, Traffic - statistics & numerical data</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Analgesics, Opioid - adverse effects</subject><subject>antidepressants</subject><subject>Antidepressive Agents</subject><subject>Automobile drivers</subject><subject>Automobile Driving</subject><subject>Benzodiazepines - adverse effects</subject><subject>Biological and medical sciences</subject><subject>Chronic Disease - epidemiology</subject><subject>crash risk</subject><subject>Cross-Over Studies</subject><subject>Databases, Factual</subject><subject>Drugs</subject><subject>Female</subject><subject>General aspects</subject><subject>Hospitalization - statistics & numerical data</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Morbidity</subject><subject>older drivers</subject><subject>Older people</subject><subject>psychoactive medications</subject><subject>Psychotropic drugs</subject><subject>Psychotropic Drugs - adverse effects</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Traffic accidents & safety</subject><subject>Western Australia - epidemiology</subject><issn>0002-8614</issn><issn>1532-5415</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkV1v0zAUhi0EYmXwF5CFhLhK8EccO0hcjMK6oY0Nxpe4sVzHZu7SuLOT0vLrcdpSJG7AN8fSed6jc_QAADHKcXrPZzlmlGSswCwnCOMcUVbifHUHjPaNu2CEECKZKHFxAB7EOEMIEyTEfXBAsBAUYzQC3WVc62uvdOeWBp6b2mnVOd9GqNoajoOK1_C0Xfpmaeam7eAHc9u74Nrv8MTHhetU435uAtD6AC-a2gT4OqRZIb6AR_DSL_pm089eqWhqeNX19fohuGdVE82jXT0En47ffByfZGcXk9Px0Vmm0zU4KwWynCk-5axUrCxthaygzHBhkCaiKmwpCkVopYwqSaF5TYTgU2RNTbVVjB6CZ9u5i-BvexM7OXdRm6ZRrfF9lBWhuBKYVv8mkeAFFgQn8slf5Mz3oU1nyLSRKAqGeILEFtLBxxiMlYvg5iqsJUZyMChnchAlB1FyMCg3BuUqRR_v5vfTuan3wd_KEvB0B6ioVWODarWLf7iCccYISdzLLffDNWb93wvIt5Or4Zfy2TbvYmdW-7wKN7LklDP55d1EsnP-_hs__iy_0l-wNMW_</recordid><startdate>201109</startdate><enddate>201109</enddate><creator>Meuleners, Lynn B.</creator><creator>Duke, Janine</creator><creator>Lee, Andy H.</creator><creator>Palamara, Peter</creator><creator>Hildebrand, Janina</creator><creator>Ng, Jonathon Q.</creator><general>Blackwell Publishing Inc</general><general>Wiley-Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>7T2</scope><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope></search><sort><creationdate>201109</creationdate><title>Psychoactive Medications and Crash Involvement Requiring Hospitalization for Older Drivers: A Population-Based Study</title><author>Meuleners, Lynn B. ; Duke, Janine ; Lee, Andy H. ; Palamara, Peter ; Hildebrand, Janina ; Ng, Jonathon Q.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5611-680f75a7b756a566f90f835e78e0c2894f684a239aea624c7d2887b0fed3cfa53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Accidents</topic><topic>Accidents, Traffic - statistics & numerical data</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Analgesics, Opioid - adverse effects</topic><topic>antidepressants</topic><topic>Antidepressive Agents</topic><topic>Automobile drivers</topic><topic>Automobile Driving</topic><topic>Benzodiazepines - adverse effects</topic><topic>Biological and medical sciences</topic><topic>Chronic Disease - epidemiology</topic><topic>crash risk</topic><topic>Cross-Over Studies</topic><topic>Databases, Factual</topic><topic>Drugs</topic><topic>Female</topic><topic>General aspects</topic><topic>Hospitalization - statistics & numerical data</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Morbidity</topic><topic>older drivers</topic><topic>Older people</topic><topic>psychoactive medications</topic><topic>Psychotropic drugs</topic><topic>Psychotropic Drugs - adverse effects</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Traffic accidents & safety</topic><topic>Western Australia - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Meuleners, Lynn B.</creatorcontrib><creatorcontrib>Duke, Janine</creatorcontrib><creatorcontrib>Lee, Andy H.</creatorcontrib><creatorcontrib>Palamara, Peter</creatorcontrib><creatorcontrib>Hildebrand, Janina</creatorcontrib><creatorcontrib>Ng, Jonathon Q.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Journal of the American Geriatrics Society (JAGS)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Meuleners, Lynn B.</au><au>Duke, Janine</au><au>Lee, Andy H.</au><au>Palamara, Peter</au><au>Hildebrand, Janina</au><au>Ng, Jonathon Q.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Psychoactive Medications and Crash Involvement Requiring Hospitalization for Older Drivers: A Population-Based Study</atitle><jtitle>Journal of the American Geriatrics Society (JAGS)</jtitle><addtitle>J Am Geriatr Soc</addtitle><date>2011-09</date><risdate>2011</risdate><volume>59</volume><issue>9</issue><spage>1575</spage><epage>1580</epage><pages>1575-1580</pages><issn>0002-8614</issn><eissn>1532-5415</eissn><coden>JAGSAF</coden><abstract>OBJECTIVES: To determine the association between psychoactive medications and crash risk in drivers aged 60 and older.
DESIGN: Retrospective population‐based case‐crossover study.
SETTING: A database study that linked the Western Australian Hospital Morbidity Data System and the Pharmaceutical Benefits Scheme.
PARTICIPANTS: Six hundred sixteen individuals aged 60 and older who were hospitalized as the result of a motor vehicle crash between 2002 and 2008 in Western Australia.
MEASUREMENTS: Hospitalization after a motor vehicle crash.
RESULTS: Greater risk for a hospitalization crash was found for older drivers prescribed benzodiazepines (odds ratio (OR)=5.3, 95% confidence interval (CI)=3.6–7.8, P<.001), antidepressants (OR=1.8, 95% CI=1.0–3.3, P=.04), and opioid analgesics (OR=1.5, 95% CI=1.0–2.3, P=.05). Crash risk was significantly greater in men prescribed a benzodiazepine (OR=6.2, 95% CI=3.2–12.2, P<.001) or an antidepressant (OR=2.7, 95% CI=1.1–6.9, P=.03). Women prescribed benzodiazepines (OR=4.9, 95% CI=3.1–7.8, P<.001) or opioid analgesics (OR=1.8, 95% CI=1.1–3.0, P=.03) also had a significantly greater crash risk. Subgroup analyses further suggested that drivers with (OR=4.0, 95% CI=2.9–8.1, P<.001) and without (OR=6.0, 95% CI=3.8–9.5, P<.001) a chronic condition who were prescribed benzodiazepines were at greater crash risk. Drivers with a chronic condition taking antidepressants (OR=3.4, 95% CI=1.3–8.5, P=.01) also had a greater crash risk.
CONCLUSION: Psychoactive medication usage was associated with greater risk of a motor vehicle crash requiring hospitalization in older drivers.</abstract><cop>Malden, USA</cop><pub>Blackwell Publishing Inc</pub><pmid>21883110</pmid><doi>10.1111/j.1532-5415.2011.03561.x</doi><tpages>6</tpages></addata></record> |
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| subjects | Accidents Accidents, Traffic - statistics & numerical data Aged Aged, 80 and over Analgesics, Opioid - adverse effects antidepressants Antidepressive Agents Automobile drivers Automobile Driving Benzodiazepines - adverse effects Biological and medical sciences Chronic Disease - epidemiology crash risk Cross-Over Studies Databases, Factual Drugs Female General aspects Hospitalization - statistics & numerical data Hospitals Humans Male Medical sciences Middle Aged Miscellaneous Morbidity older drivers Older people psychoactive medications Psychotropic drugs Psychotropic Drugs - adverse effects Public health. Hygiene Public health. Hygiene-occupational medicine Retrospective Studies Risk Factors Traffic accidents & safety Western Australia - epidemiology |
| title | Psychoactive Medications and Crash Involvement Requiring Hospitalization for Older Drivers: A Population-Based Study |
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