Determinants of tick-borne encephalitis virus antibody presence in roe deer (Capreolus capreolus) sera

In order to identify variables associated with the presence of the tick‐borne encephalitis (TBE) virus, we conducted a serological survey of roe deer [Capreolus capreolus (Artiodactyla: Cervidae, Linnaeus 1758)] in three forest districts of southern Hesse, Germany. Overall, 24 out of 105 (22.9%) of...

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Veröffentlicht in:Medical and veterinary entomology 2012-03, Vol.26 (1), p.18-25
Hauptverfasser: KIFFNER, C., VOR, T., HAGEDORN, P., NIEDRIG, M., RÜHE, F.
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container_start_page 18
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VOR, T.
HAGEDORN, P.
NIEDRIG, M.
RÜHE, F.
description In order to identify variables associated with the presence of the tick‐borne encephalitis (TBE) virus, we conducted a serological survey of roe deer [Capreolus capreolus (Artiodactyla: Cervidae, Linnaeus 1758)] in three forest districts of southern Hesse, Germany. Overall, 24 out of 105 (22.9%) of the sera were positive (≥1 : 10 plaque reduction neutralization test). Using a logistic regression approach, we found that unexplained spatial variation, indexed roe deer density (positive correlation), hind foot length of the tested roe deer (positive correlation) and infestation with female Ixodes spp. ticks (negative correlation) predicted the probability of TBE virus antibody presence in individual roe deer sera. Spring temperature increase and host sex were rejected as explanatory variables. We found considerable differences in TBE virus antibody seroprevalence (50.0% vs. 17.6%) between two forest districts located in the same county; this finding questions the current county‐resolution of public health recordings. Given the high seroprevalence of roe deer and the considerable explanatory power of our model, our approach appears suitable to delineate science‐based risk maps at a smaller spatial scale and to abandon the current human incidence per county criterion. Importantly, using roe deer as sentinels would eliminate the inherent bias of risk maps based on human incidence (varying levels of immunization and exposure of humans).
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Overall, 24 out of 105 (22.9%) of the sera were positive (≥1 : 10 plaque reduction neutralization test). Using a logistic regression approach, we found that unexplained spatial variation, indexed roe deer density (positive correlation), hind foot length of the tested roe deer (positive correlation) and infestation with female Ixodes spp. ticks (negative correlation) predicted the probability of TBE virus antibody presence in individual roe deer sera. Spring temperature increase and host sex were rejected as explanatory variables. We found considerable differences in TBE virus antibody seroprevalence (50.0% vs. 17.6%) between two forest districts located in the same county; this finding questions the current county‐resolution of public health recordings. Given the high seroprevalence of roe deer and the considerable explanatory power of our model, our approach appears suitable to delineate science‐based risk maps at a smaller spatial scale and to abandon the current human incidence per county criterion. Importantly, using roe deer as sentinels would eliminate the inherent bias of risk maps based on human incidence (varying levels of immunization and exposure of humans).</description><identifier>ISSN: 0269-283X</identifier><identifier>EISSN: 1365-2915</identifier><identifier>DOI: 10.1111/j.1365-2915.2011.00961.x</identifier><identifier>PMID: 21592155</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Animals ; Antibodies, Viral - blood ; Artiodactyla ; Capreolus capreolus ; Cervidae ; Deer ; Demography ; Encephalitis Viruses, Tick-Borne - immunology ; Encephalitis, Tick-Borne - blood ; Encephalitis, Tick-Borne - epidemiology ; Encephalitis, Tick-Borne - immunology ; Encephalitis, Tick-Borne - veterinary ; Female ; Germany - epidemiology ; host-pathogen interaction ; Ixodes ; Ixodes - physiology ; Ixodes ricinus ; Ixodidae ; Male ; Risk Factors ; risk mapping ; Tick Infestations - veterinary ; Tick-borne encephalitis virus ; tick-borne pathogens ; Trees</subject><ispartof>Medical and veterinary entomology, 2012-03, Vol.26 (1), p.18-25</ispartof><rights>2011 The Authors. 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Overall, 24 out of 105 (22.9%) of the sera were positive (≥1 : 10 plaque reduction neutralization test). Using a logistic regression approach, we found that unexplained spatial variation, indexed roe deer density (positive correlation), hind foot length of the tested roe deer (positive correlation) and infestation with female Ixodes spp. ticks (negative correlation) predicted the probability of TBE virus antibody presence in individual roe deer sera. Spring temperature increase and host sex were rejected as explanatory variables. We found considerable differences in TBE virus antibody seroprevalence (50.0% vs. 17.6%) between two forest districts located in the same county; this finding questions the current county‐resolution of public health recordings. Given the high seroprevalence of roe deer and the considerable explanatory power of our model, our approach appears suitable to delineate science‐based risk maps at a smaller spatial scale and to abandon the current human incidence per county criterion. 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Overall, 24 out of 105 (22.9%) of the sera were positive (≥1 : 10 plaque reduction neutralization test). Using a logistic regression approach, we found that unexplained spatial variation, indexed roe deer density (positive correlation), hind foot length of the tested roe deer (positive correlation) and infestation with female Ixodes spp. ticks (negative correlation) predicted the probability of TBE virus antibody presence in individual roe deer sera. Spring temperature increase and host sex were rejected as explanatory variables. We found considerable differences in TBE virus antibody seroprevalence (50.0% vs. 17.6%) between two forest districts located in the same county; this finding questions the current county‐resolution of public health recordings. Given the high seroprevalence of roe deer and the considerable explanatory power of our model, our approach appears suitable to delineate science‐based risk maps at a smaller spatial scale and to abandon the current human incidence per county criterion. Importantly, using roe deer as sentinels would eliminate the inherent bias of risk maps based on human incidence (varying levels of immunization and exposure of humans).</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>21592155</pmid><doi>10.1111/j.1365-2915.2011.00961.x</doi><tpages>8</tpages></addata></record>
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subjects Animals
Antibodies, Viral - blood
Artiodactyla
Capreolus capreolus
Cervidae
Deer
Demography
Encephalitis Viruses, Tick-Borne - immunology
Encephalitis, Tick-Borne - blood
Encephalitis, Tick-Borne - epidemiology
Encephalitis, Tick-Borne - immunology
Encephalitis, Tick-Borne - veterinary
Female
Germany - epidemiology
host-pathogen interaction
Ixodes
Ixodes - physiology
Ixodes ricinus
Ixodidae
Male
Risk Factors
risk mapping
Tick Infestations - veterinary
Tick-borne encephalitis virus
tick-borne pathogens
Trees
title Determinants of tick-borne encephalitis virus antibody presence in roe deer (Capreolus capreolus) sera
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