The efficacy of Implanon for the treatment of chronic pelvic pain associated with pelvic congestion: 1-year randomized controlled pilot study
Objective To evaluate the beneficial effects of Implanon on pelvic pain in women with pelvic congestion syndrome (PCS). The efficacy of pain control, amount and frequency of menstrual loss, degree of patient’s satisfaction and objective pelvic venography scores were investigated. Methods In a prospe...
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| Veröffentlicht in: | Archives of gynecology and obstetrics 2009-09, Vol.280 (3), p.437-443 |
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| creator | Shokeir, Tarek Amr, Mostafa Abdelshaheed, Mahmoud |
| description | Objective
To evaluate the beneficial effects of Implanon on pelvic pain in women with pelvic congestion syndrome (PCS). The efficacy of pain control, amount and frequency of menstrual loss, degree of patient’s satisfaction and objective pelvic venography scores were investigated.
Methods
In a prospective open-labelled study, 25 consecutive women complaining of chronic pelvic pain were recruited. Pretreatment objective peruterine venography and diagnostic laparoscopy of pure PCS together with subjective pelvic pain scores, prefilled questionnaire of Hospital Anxiety and Depression Scale (HADS), visual analogue scale (VAS), verbal rating scale (VRS) and quantified menstrual loss using the pictorial blood loss chart were documented in all cases. After identification, 23 subjects with pure PCS were randomly assigned to have either Implanon inserted subcutaneously (12 cases) or no treatment (11 cases). Patients were followed up at 1, 3, 6, 9 and 12 months. A symptom diary for side effects, VAS, VRS and menstrual scores were used to assess the subjective response to treatment. At the end of the study, all patients underwent repeat venography to assess the long-term objective response. After 12 months, subjects having Implanon inserted were requested to rate their overall degree of satisfaction with therapy.
Results
All 25 women recruited in the study completed follow-up. Two cases were excluded from the study and referred to the psychiatry department after a negative evaluation for disease and HADS scores relevant for depression. An improvement in symptoms was observed throughout the 12 months amongst the Implanon group versus no treatment. The greatest changes in pain assessed using either the VAS or VRS were between the pretreatment scores and those after 6 months (7.7 ± 1.3 vs. 4.6 ± 3.0 for VAS,
P
|
| doi_str_mv | 10.1007/s00404-009-0951-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_923196576</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>923196576</sourcerecordid><originalsourceid>FETCH-LOGICAL-c402t-364c02d180c9f6cb666b49283e5d3c95479cf9d48b2cd1c9ba7b18fd76afdf713</originalsourceid><addsrcrecordid>eNp9kc2KFTEQhYMoznX0AdxIQNBVayrdnXTcyTCjAwNuxnVI58eboTtpk_TI9R18Z9PcKwOCrqrgfHUqlYPQSyDvgBD-PhPSka4hRDRE9NDAI7SDrqUN4QCP0Y6IrSeMn6FnOd8RAnQY2FN0BgIEEZTv0K_bvcXWOa-VPuDo8PW8TCrEgF1MuFSxJKvKbEPZVL1PMXiNFzvdb0X5gFXOUXtVrME_fNn_0XQM32wuPoYPGJqDVQknFUyc_c9KVrWkOE21XfwUC85lNYfn6IlTU7YvTvUcfb26vL343Nx8-XR98fGm0R2hpWlZpwk1MBAtHNMjY2zsBB1a25tWi77jQjthumGk2oAWo-IjDM5wppxxHNpz9Pbou6T4fa2vlLPP2k71chvXLAVtQbCes0q--S_JeA-sh83y9V_gXVxTqFdIShkMQyv6tlJwpHSKOSfr5JL8rNJBApFbpvKYqayZyi1TuTm_Ojmv42zNw8QpxArQI5CrVD89Paz-t-tv6oeuBQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2261883953</pqid></control><display><type>article</type><title>The efficacy of Implanon for the treatment of chronic pelvic pain associated with pelvic congestion: 1-year randomized controlled pilot study</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Shokeir, Tarek ; Amr, Mostafa ; Abdelshaheed, Mahmoud</creator><creatorcontrib>Shokeir, Tarek ; Amr, Mostafa ; Abdelshaheed, Mahmoud</creatorcontrib><description>Objective
To evaluate the beneficial effects of Implanon on pelvic pain in women with pelvic congestion syndrome (PCS). The efficacy of pain control, amount and frequency of menstrual loss, degree of patient’s satisfaction and objective pelvic venography scores were investigated.
Methods
In a prospective open-labelled study, 25 consecutive women complaining of chronic pelvic pain were recruited. Pretreatment objective peruterine venography and diagnostic laparoscopy of pure PCS together with subjective pelvic pain scores, prefilled questionnaire of Hospital Anxiety and Depression Scale (HADS), visual analogue scale (VAS), verbal rating scale (VRS) and quantified menstrual loss using the pictorial blood loss chart were documented in all cases. After identification, 23 subjects with pure PCS were randomly assigned to have either Implanon inserted subcutaneously (12 cases) or no treatment (11 cases). Patients were followed up at 1, 3, 6, 9 and 12 months. A symptom diary for side effects, VAS, VRS and menstrual scores were used to assess the subjective response to treatment. At the end of the study, all patients underwent repeat venography to assess the long-term objective response. After 12 months, subjects having Implanon inserted were requested to rate their overall degree of satisfaction with therapy.
Results
All 25 women recruited in the study completed follow-up. Two cases were excluded from the study and referred to the psychiatry department after a negative evaluation for disease and HADS scores relevant for depression. An improvement in symptoms was observed throughout the 12 months amongst the Implanon group versus no treatment. The greatest changes in pain assessed using either the VAS or VRS were between the pretreatment scores and those after 6 months (7.7 ± 1.3 vs. 4.6 ± 3.0 for VAS,
P
< 0.001; and 25 ± 13.8 vs. 19 ± 18.9 for VRS,
P
< 0.002). The monthly quantified blood loss fell from 204 (196) pretreatment to 90 (157) at 6 months (
P
< 0.001) and then to 64 (32) at 9 months (
P
< 0.002). Objective repeat venography score was reduced significantly at 1 year after treatment compared with the baseline evaluation as well as with the control group (4.5 ± 1.2 vs. 8.6 ± 0.5;
P
= 0.001 and 4.2 ± 0.9 vs. 8.5 ± 0.6;
P
= 0.0002, respectively). At final satisfaction assessment, 2 (17%) women were very satisfied 8 (66%) were satisfied, and 2 (17%) were uncertain. The implant was retained by all women at the end of the study.
Conclusion
Implanon seems to be an effective hormonal alternative for long-term treatment of properly selected patients with pure PCS-related pelvic pain.</description><identifier>ISSN: 0932-0067</identifier><identifier>EISSN: 1432-0711</identifier><identifier>DOI: 10.1007/s00404-009-0951-1</identifier><identifier>PMID: 19190927</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Adult ; Chronic Disease ; Contraceptive Agents, Female - therapeutic use ; Desogestrel - therapeutic use ; Endocrinology ; Female ; Gynecology ; Human Genetics ; Humans ; Hysterectomy ; Medicine ; Medicine & Public Health ; Menstruation ; Obstetrics/Perinatology/Midwifery ; Original Article ; Pain ; Pain Measurement ; Pelvic Pain - diagnosis ; Pelvic Pain - drug therapy ; Pelvic Pain - etiology ; Pelvis - blood supply ; Pilot Projects ; Prospective Studies ; Venous Insufficiency - complications ; Venous Insufficiency - diagnosis</subject><ispartof>Archives of gynecology and obstetrics, 2009-09, Vol.280 (3), p.437-443</ispartof><rights>Springer-Verlag 2009</rights><rights>Springer-Verlag 2009.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c402t-364c02d180c9f6cb666b49283e5d3c95479cf9d48b2cd1c9ba7b18fd76afdf713</citedby><cites>FETCH-LOGICAL-c402t-364c02d180c9f6cb666b49283e5d3c95479cf9d48b2cd1c9ba7b18fd76afdf713</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00404-009-0951-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00404-009-0951-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19190927$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shokeir, Tarek</creatorcontrib><creatorcontrib>Amr, Mostafa</creatorcontrib><creatorcontrib>Abdelshaheed, Mahmoud</creatorcontrib><title>The efficacy of Implanon for the treatment of chronic pelvic pain associated with pelvic congestion: 1-year randomized controlled pilot study</title><title>Archives of gynecology and obstetrics</title><addtitle>Arch Gynecol Obstet</addtitle><addtitle>Arch Gynecol Obstet</addtitle><description>Objective
To evaluate the beneficial effects of Implanon on pelvic pain in women with pelvic congestion syndrome (PCS). The efficacy of pain control, amount and frequency of menstrual loss, degree of patient’s satisfaction and objective pelvic venography scores were investigated.
Methods
In a prospective open-labelled study, 25 consecutive women complaining of chronic pelvic pain were recruited. Pretreatment objective peruterine venography and diagnostic laparoscopy of pure PCS together with subjective pelvic pain scores, prefilled questionnaire of Hospital Anxiety and Depression Scale (HADS), visual analogue scale (VAS), verbal rating scale (VRS) and quantified menstrual loss using the pictorial blood loss chart were documented in all cases. After identification, 23 subjects with pure PCS were randomly assigned to have either Implanon inserted subcutaneously (12 cases) or no treatment (11 cases). Patients were followed up at 1, 3, 6, 9 and 12 months. A symptom diary for side effects, VAS, VRS and menstrual scores were used to assess the subjective response to treatment. At the end of the study, all patients underwent repeat venography to assess the long-term objective response. After 12 months, subjects having Implanon inserted were requested to rate their overall degree of satisfaction with therapy.
Results
All 25 women recruited in the study completed follow-up. Two cases were excluded from the study and referred to the psychiatry department after a negative evaluation for disease and HADS scores relevant for depression. An improvement in symptoms was observed throughout the 12 months amongst the Implanon group versus no treatment. The greatest changes in pain assessed using either the VAS or VRS were between the pretreatment scores and those after 6 months (7.7 ± 1.3 vs. 4.6 ± 3.0 for VAS,
P
< 0.001; and 25 ± 13.8 vs. 19 ± 18.9 for VRS,
P
< 0.002). The monthly quantified blood loss fell from 204 (196) pretreatment to 90 (157) at 6 months (
P
< 0.001) and then to 64 (32) at 9 months (
P
< 0.002). Objective repeat venography score was reduced significantly at 1 year after treatment compared with the baseline evaluation as well as with the control group (4.5 ± 1.2 vs. 8.6 ± 0.5;
P
= 0.001 and 4.2 ± 0.9 vs. 8.5 ± 0.6;
P
= 0.0002, respectively). At final satisfaction assessment, 2 (17%) women were very satisfied 8 (66%) were satisfied, and 2 (17%) were uncertain. The implant was retained by all women at the end of the study.
Conclusion
Implanon seems to be an effective hormonal alternative for long-term treatment of properly selected patients with pure PCS-related pelvic pain.</description><subject>Adult</subject><subject>Chronic Disease</subject><subject>Contraceptive Agents, Female - therapeutic use</subject><subject>Desogestrel - therapeutic use</subject><subject>Endocrinology</subject><subject>Female</subject><subject>Gynecology</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Hysterectomy</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Menstruation</subject><subject>Obstetrics/Perinatology/Midwifery</subject><subject>Original Article</subject><subject>Pain</subject><subject>Pain Measurement</subject><subject>Pelvic Pain - diagnosis</subject><subject>Pelvic Pain - drug therapy</subject><subject>Pelvic Pain - etiology</subject><subject>Pelvis - blood supply</subject><subject>Pilot Projects</subject><subject>Prospective Studies</subject><subject>Venous Insufficiency - complications</subject><subject>Venous Insufficiency - diagnosis</subject><issn>0932-0067</issn><issn>1432-0711</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kc2KFTEQhYMoznX0AdxIQNBVayrdnXTcyTCjAwNuxnVI58eboTtpk_TI9R18Z9PcKwOCrqrgfHUqlYPQSyDvgBD-PhPSka4hRDRE9NDAI7SDrqUN4QCP0Y6IrSeMn6FnOd8RAnQY2FN0BgIEEZTv0K_bvcXWOa-VPuDo8PW8TCrEgF1MuFSxJKvKbEPZVL1PMXiNFzvdb0X5gFXOUXtVrME_fNn_0XQM32wuPoYPGJqDVQknFUyc_c9KVrWkOE21XfwUC85lNYfn6IlTU7YvTvUcfb26vL343Nx8-XR98fGm0R2hpWlZpwk1MBAtHNMjY2zsBB1a25tWi77jQjthumGk2oAWo-IjDM5wppxxHNpz9Pbou6T4fa2vlLPP2k71chvXLAVtQbCes0q--S_JeA-sh83y9V_gXVxTqFdIShkMQyv6tlJwpHSKOSfr5JL8rNJBApFbpvKYqayZyi1TuTm_Ojmv42zNw8QpxArQI5CrVD89Paz-t-tv6oeuBQ</recordid><startdate>20090901</startdate><enddate>20090901</enddate><creator>Shokeir, Tarek</creator><creator>Amr, Mostafa</creator><creator>Abdelshaheed, Mahmoud</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20090901</creationdate><title>The efficacy of Implanon for the treatment of chronic pelvic pain associated with pelvic congestion: 1-year randomized controlled pilot study</title><author>Shokeir, Tarek ; Amr, Mostafa ; Abdelshaheed, Mahmoud</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c402t-364c02d180c9f6cb666b49283e5d3c95479cf9d48b2cd1c9ba7b18fd76afdf713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Chronic Disease</topic><topic>Contraceptive Agents, Female - therapeutic use</topic><topic>Desogestrel - therapeutic use</topic><topic>Endocrinology</topic><topic>Female</topic><topic>Gynecology</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Hysterectomy</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Menstruation</topic><topic>Obstetrics/Perinatology/Midwifery</topic><topic>Original Article</topic><topic>Pain</topic><topic>Pain Measurement</topic><topic>Pelvic Pain - diagnosis</topic><topic>Pelvic Pain - drug therapy</topic><topic>Pelvic Pain - etiology</topic><topic>Pelvis - blood supply</topic><topic>Pilot Projects</topic><topic>Prospective Studies</topic><topic>Venous Insufficiency - complications</topic><topic>Venous Insufficiency - diagnosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shokeir, Tarek</creatorcontrib><creatorcontrib>Amr, Mostafa</creatorcontrib><creatorcontrib>Abdelshaheed, Mahmoud</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Archives of gynecology and obstetrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shokeir, Tarek</au><au>Amr, Mostafa</au><au>Abdelshaheed, Mahmoud</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The efficacy of Implanon for the treatment of chronic pelvic pain associated with pelvic congestion: 1-year randomized controlled pilot study</atitle><jtitle>Archives of gynecology and obstetrics</jtitle><stitle>Arch Gynecol Obstet</stitle><addtitle>Arch Gynecol Obstet</addtitle><date>2009-09-01</date><risdate>2009</risdate><volume>280</volume><issue>3</issue><spage>437</spage><epage>443</epage><pages>437-443</pages><issn>0932-0067</issn><eissn>1432-0711</eissn><abstract>Objective
To evaluate the beneficial effects of Implanon on pelvic pain in women with pelvic congestion syndrome (PCS). The efficacy of pain control, amount and frequency of menstrual loss, degree of patient’s satisfaction and objective pelvic venography scores were investigated.
Methods
In a prospective open-labelled study, 25 consecutive women complaining of chronic pelvic pain were recruited. Pretreatment objective peruterine venography and diagnostic laparoscopy of pure PCS together with subjective pelvic pain scores, prefilled questionnaire of Hospital Anxiety and Depression Scale (HADS), visual analogue scale (VAS), verbal rating scale (VRS) and quantified menstrual loss using the pictorial blood loss chart were documented in all cases. After identification, 23 subjects with pure PCS were randomly assigned to have either Implanon inserted subcutaneously (12 cases) or no treatment (11 cases). Patients were followed up at 1, 3, 6, 9 and 12 months. A symptom diary for side effects, VAS, VRS and menstrual scores were used to assess the subjective response to treatment. At the end of the study, all patients underwent repeat venography to assess the long-term objective response. After 12 months, subjects having Implanon inserted were requested to rate their overall degree of satisfaction with therapy.
Results
All 25 women recruited in the study completed follow-up. Two cases were excluded from the study and referred to the psychiatry department after a negative evaluation for disease and HADS scores relevant for depression. An improvement in symptoms was observed throughout the 12 months amongst the Implanon group versus no treatment. The greatest changes in pain assessed using either the VAS or VRS were between the pretreatment scores and those after 6 months (7.7 ± 1.3 vs. 4.6 ± 3.0 for VAS,
P
< 0.001; and 25 ± 13.8 vs. 19 ± 18.9 for VRS,
P
< 0.002). The monthly quantified blood loss fell from 204 (196) pretreatment to 90 (157) at 6 months (
P
< 0.001) and then to 64 (32) at 9 months (
P
< 0.002). Objective repeat venography score was reduced significantly at 1 year after treatment compared with the baseline evaluation as well as with the control group (4.5 ± 1.2 vs. 8.6 ± 0.5;
P
= 0.001 and 4.2 ± 0.9 vs. 8.5 ± 0.6;
P
= 0.0002, respectively). At final satisfaction assessment, 2 (17%) women were very satisfied 8 (66%) were satisfied, and 2 (17%) were uncertain. The implant was retained by all women at the end of the study.
Conclusion
Implanon seems to be an effective hormonal alternative for long-term treatment of properly selected patients with pure PCS-related pelvic pain.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>19190927</pmid><doi>10.1007/s00404-009-0951-1</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0932-0067 |
| ispartof | Archives of gynecology and obstetrics, 2009-09, Vol.280 (3), p.437-443 |
| issn | 0932-0067 1432-0711 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_923196576 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adult Chronic Disease Contraceptive Agents, Female - therapeutic use Desogestrel - therapeutic use Endocrinology Female Gynecology Human Genetics Humans Hysterectomy Medicine Medicine & Public Health Menstruation Obstetrics/Perinatology/Midwifery Original Article Pain Pain Measurement Pelvic Pain - diagnosis Pelvic Pain - drug therapy Pelvic Pain - etiology Pelvis - blood supply Pilot Projects Prospective Studies Venous Insufficiency - complications Venous Insufficiency - diagnosis |
| title | The efficacy of Implanon for the treatment of chronic pelvic pain associated with pelvic congestion: 1-year randomized controlled pilot study |
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