HIF-1α is neuroprotective during the early phases of mild hypoxia in rat cortical neurons

Hypoxia-inducible factor 1α (HIF-1α) is a transcription factor that plays a key role in regulating the adaptive response to hypoxia. HIF-1α is stabilised during hypoxia and, after dimerisation with hypoxia-inducible factor 1β (HIF-1β), triggers the expression of various genes involved in cell cycle...

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Veröffentlicht in:	Experimental neurology 2012-01, Vol.233 (1), p.543-554
Hauptverfasser:	López-Hernández, Beatriz, Posadas, Inmaculada, Podlesniy, Petar, Abad, María A., Trullas, Ramón, Ceña, Valentín
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Apoptosis Biological and medical sciences Cell Death Cells, Cultured Cerebral Cortex - cytology Cyclooxygenase 1 - metabolism Cytochromes c - metabolism Dose-Response Relationship, Drug Free Radical Scavengers - pharmacology Gene Expression Regulation - drug effects Gene Expression Regulation - physiology Glutathione - metabolism Green Fluorescent Proteins - genetics HIF-1α Hypoxia Hypoxia - metabolism Hypoxia - pathology Hypoxia-Inducible Factor 1, alpha Subunit - genetics Hypoxia-Inducible Factor 1, alpha Subunit - metabolism L-Lactate Dehydrogenase - metabolism Lentivirus Medical sciences Membrane Potential, Mitochondrial - physiology Membrane Proteins - metabolism Metalloporphyrins - pharmacology Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Neurology Neurons Neurons - drug effects Neurons - ultrastructure Neuroprotection Oxygen - metabolism Phenanthridines Rats Rats, Sprague-Dawley Reactive Oxygen Species RNA Interference - physiology shRNA Tetrazolium Salts Thiazoles Time Factors
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