Transgenic overexpression of USP15 in the heart induces cardiac remodeling in mice

► USP15 directly interacts with SLIM1, and deubiquitinates and stabilizes SLIM1. ► USP15 overexpression in transgenic mice induces cardiac hypertrophic responses. ► Protein levels of SLIM1 increases in the heart of USP15-trangenic (TG) mice. ► Splice variant isoform of SLIM1 is upregulated at mRNA a...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biochemical and biophysical research communications 2011-02, Vol.405 (2), p.216-221
Hauptverfasser:	Isumi, Yoshitaka, Hirata, Tsuyoshi, Saitoh, Hiroshi, Miyakawa, Tomoya, Murakami, Kenji, Kudoh, Gen, Doi, Hirofumi, Ishibashi, Kohtaro, Nakajima, Hiroto
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cardiomegaly - genetics Cardiomegaly - metabolism Cardiomegaly - pathology Cardiomyopathy Deubiquitination Endopeptidases - metabolism Four-and-a-half LIM domains Humans Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism LIM Domain Proteins Mice Mice, Transgenic Muscle Proteins - genetics Muscle Proteins - metabolism Myocardium - enzymology Myocardium - pathology Protein Processing, Post-Translational Skeletal muscle Ubiquitin-Specific Proteases
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!