γ-Carbolines: A novel class of cannabinoid agonists with high aqueous solubility and restricted CNS penetration

An oral, peripherally restricted CB1/CB2 agonist could provide an interesting approach to treat chronic pain by harnessing the analgesic properties of cannabinoids but without the well-known central side effects. γ-Carbolines are a novel class of potent mixed CB1/CB2 agonists characterized by attrac...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2012-02, Vol.22 (4), p.1619-1624
Hauptverfasser:	Cheng, Yun-Xing, Pourashraf, Mehrnaz, Luo, Xuehong, Srivastava, Sanjay, Walpole, Christopher, Salois, Dominic, St-Onge, Stephane, Payza, Kemal, Lessard, Etienne, Yu, Xiao Hong, Tomaszewski, Mirosław J.
Format:	Artikel
Sprache:	eng
Schlagworte:	adverse effects agonists analgesic effect Analgesics Analgesics - chemistry Analgesics - metabolism Analgesics - pharmacology Animal models Animals Biological and medical sciences Brain Brain - drug effects Brain - metabolism Cannabinoid Cannabinoid CB1 receptors Cannabinoid CB2 receptors cannabinoids Cannabinoids - agonists Carbolines Carbolines - chemistry Carbolines - metabolism Carbolines - pharmacology Cell Line Central nervous system Chronic pain Drug addictions Drug Stability Humans Inflammation Medical sciences Molecular Structure Pain Pain - drug therapy Pharmacology. Drug treatments Physicochemical properties Rats risk Risk factors Side effects Solubility Toxicology
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