Selective phosphodiesterase inhibitors improve performance on the ED/ID cognitive task in rats

A number of selective phosphodiesterase (PDE) inhibitors have been demonstrated to improve learning in several rodent models of cognition. Given that schizophrenia is associated with impairments in frontal lobe-dependent cognitive functions (e.g., working memory and cognitive flexibility), we examin...

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Veröffentlicht in:	Neuropharmacology 2012-03, Vol.62 (3), p.1182-1190
Hauptverfasser:	Rodefer, Joshua S., Saland, Samantha K., Eckrich, Samuel J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Attention Cognition Cognition - drug effects Executive function Frontal cortex Learning Male Neuropsychological Tests Phencyclidine - pharmacology Phosphodiesterase Inhibitors - pharmacology Primates Psychomotor Performance - drug effects Rats Rats, Long-Evans Set shifting
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