Key Role of Macrophages in the Pathogenesis of CD18 Hypomorphic Murine Model of Psoriasis

Psoriasis is a chronic skin disorder of unsolved pathogenesis affecting skin in 2–3% of the general population. Research into the pathogenesis of psoriasis has profited from suitable animal models. Previously, we reported on the CD18 hypomorphic (CD18hypo) PL/J mouse model clinically resembling huma...

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Veröffentlicht in:	Journal of investigative dermatology 2009-05, Vol.129 (5), p.1100-1114
Hauptverfasser:	Wang, Honglin, Peters, Thorsten, Sindrilaru, Anca, Scharffetter-Kochanek, Karin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences CD18 Antigens - genetics CD18 Antigens - metabolism Dermatology Disease Models, Animal Macrophages - immunology Macrophages - pathology Macrophages - physiology Medical sciences Mice Psoriasis - etiology Psoriasis - immunology Psoriasis - pathology Psoriasis. Parapsoriasis. Lichen T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - pathology T-Lymphocytes, Regulatory - physiology Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - metabolism
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