Metastatic Hepatocellular Carcinoma With Associated Spinal Cord Compression
Abstract Metastatic hepatocellular carcinoma is a rare occurrence in the United States. The prognosis is poor, with a survival time of months from the time of diagnosis. This article reports a case of myelopathy that developed from metastases in a patient with no significant medical history. The pat...
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| Veröffentlicht in: | The American journal of the medical sciences 2011-02, Vol.341 (2), p.148-152 |
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| container_title | The American journal of the medical sciences |
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| creator | Vargas, Jan, BS Gowans, Mathew, BA Vandergrift, William A., MD Giglio, Pierre, MD Hope, Jason, MD |
| description | Abstract Metastatic hepatocellular carcinoma is a rare occurrence in the United States. The prognosis is poor, with a survival time of months from the time of diagnosis. This article reports a case of myelopathy that developed from metastases in a patient with no significant medical history. The patient was treated with decompressive laminectomy followed by adjuvant radiotherapy. A review of the literature demonstrated that most cases from hepatocellular carcinoma metastasizing to the spinal cord involve either the thoracic or lumbar levels and arise from the right liver lobe or both lobes. Major risk factors included positive hepatitis B virus serologies. This article also discusses current trends in management of epidural spinal cord compression. Although treatment with chemotherapy has not shown any benefit, surgical management has been shown to decrease morbidity and mortality in some patients. |
| doi_str_mv | 10.1097/MAJ.0b013e3181f7a49a |
| format | Article |
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The prognosis is poor, with a survival time of months from the time of diagnosis. This article reports a case of myelopathy that developed from metastases in a patient with no significant medical history. The patient was treated with decompressive laminectomy followed by adjuvant radiotherapy. A review of the literature demonstrated that most cases from hepatocellular carcinoma metastasizing to the spinal cord involve either the thoracic or lumbar levels and arise from the right liver lobe or both lobes. Major risk factors included positive hepatitis B virus serologies. This article also discusses current trends in management of epidural spinal cord compression. Although treatment with chemotherapy has not shown any benefit, surgical management has been shown to decrease morbidity and mortality in some patients.</description><identifier>ISSN: 0002-9629</identifier><identifier>EISSN: 1538-2990</identifier><identifier>DOI: 10.1097/MAJ.0b013e3181f7a49a</identifier><identifier>PMID: 21107234</identifier><identifier>CODEN: AJMSA9</identifier><language>eng</language><publisher>Hagerstown, MD: Elsevier Inc</publisher><subject>Biological and medical sciences ; Carcinoma, Hepatocellular - complications ; Carcinoma, Hepatocellular - diagnosis ; Carcinoma, Hepatocellular - secondary ; Cerebrospinal fluid. Meninges. Spinal cord ; Epidural spinal cord compression ; Fatal Outcome ; Gastroenterology. Liver. Pancreas. Abdomen ; General aspects ; Humans ; Internal Medicine ; Laminectomy ; Liver Neoplasms - diagnosis ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Metastatic hepatocellular carcinoma ; Middle Aged ; Nervous system (semeiology, syndromes) ; Neurology ; Spinal Cord Compression - diagnosis ; Spinal Cord Compression - etiology ; Spinal Cord Compression - surgery ; Spinal Cord Neoplasms - complications ; Spinal Cord Neoplasms - diagnosis ; Spinal Cord Neoplasms - secondary ; Spinal Cord Neoplasms - surgery ; Spine ; Tumors</subject><ispartof>The American journal of the medical sciences, 2011-02, Vol.341 (2), p.148-152</ispartof><rights>Southern Society for Clinical Investigation</rights><rights>2011 Southern Society for Clinical Investigation</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c478t-1d7d078ee61c0cd559ff0b6dd84b9f71c9d66df9197a40d6cf522b537a710c723</citedby><cites>FETCH-LOGICAL-c478t-1d7d078ee61c0cd559ff0b6dd84b9f71c9d66df9197a40d6cf522b537a710c723</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23840390$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21107234$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vargas, Jan, BS</creatorcontrib><creatorcontrib>Gowans, Mathew, BA</creatorcontrib><creatorcontrib>Vandergrift, William A., MD</creatorcontrib><creatorcontrib>Giglio, Pierre, MD</creatorcontrib><creatorcontrib>Hope, Jason, MD</creatorcontrib><title>Metastatic Hepatocellular Carcinoma With Associated Spinal Cord Compression</title><title>The American journal of the medical sciences</title><addtitle>Am J Med Sci</addtitle><description>Abstract Metastatic hepatocellular carcinoma is a rare occurrence in the United States. The prognosis is poor, with a survival time of months from the time of diagnosis. This article reports a case of myelopathy that developed from metastases in a patient with no significant medical history. The patient was treated with decompressive laminectomy followed by adjuvant radiotherapy. A review of the literature demonstrated that most cases from hepatocellular carcinoma metastasizing to the spinal cord involve either the thoracic or lumbar levels and arise from the right liver lobe or both lobes. Major risk factors included positive hepatitis B virus serologies. This article also discusses current trends in management of epidural spinal cord compression. Although treatment with chemotherapy has not shown any benefit, surgical management has been shown to decrease morbidity and mortality in some patients.</description><subject>Biological and medical sciences</subject><subject>Carcinoma, Hepatocellular - complications</subject><subject>Carcinoma, Hepatocellular - diagnosis</subject><subject>Carcinoma, Hepatocellular - secondary</subject><subject>Cerebrospinal fluid. Meninges. Spinal cord</subject><subject>Epidural spinal cord compression</subject><subject>Fatal Outcome</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>General aspects</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Laminectomy</subject><subject>Liver Neoplasms - diagnosis</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metastatic hepatocellular carcinoma</subject><subject>Middle Aged</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Spinal Cord Compression - diagnosis</subject><subject>Spinal Cord Compression - etiology</subject><subject>Spinal Cord Compression - surgery</subject><subject>Spinal Cord Neoplasms - complications</subject><subject>Spinal Cord Neoplasms - diagnosis</subject><subject>Spinal Cord Neoplasms - secondary</subject><subject>Spinal Cord Neoplasms - surgery</subject><subject>Spine</subject><subject>Tumors</subject><issn>0002-9629</issn><issn>1538-2990</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk1v1DAQhi0EosvCP0AoF8QpZcbOh31BWq2AAq04FAQ3y7EnwiWJFztB6r_H0S4g9dKLfXlm_M7jYew5wjmCal9f7T6eQwcoSKDEvjWVMg_YBmshS64UPGQbAOClarg6Y09SugFALlE8ZmccEVouqg37dEWzSbOZvS0u6GDmYGkYlsHEYm-i9VMYTfHNzz-KXUrBejOTK64PfjJDsQ_R5WM8RErJh-kpe9SbIdGz071lX9-9_bK_KC8_v_-w312WtmrlXKJrHbSSqEEL1tW16nvoGudk1am-Ratc07heocozgWtsX3Pe1aI1LYLNsbfs1bHvIYZfC6VZjz6tsc1EYUlacYFKAId7SVlJgQKysy2rjqSNIaVIvT5EP5p4qxH06ltn3_qu71z24vTA0o3k_hX9FZyBlyfAJGuGPprJ-vSfE7ICodakb44cZXG_PUWdrKfJkvOR7Kxd8PcludvADn7y-c2fdEvpJiwx_1nSqBPXoK_X3VhXI8-OQsJ38Qcr8bK0</recordid><startdate>20110201</startdate><enddate>20110201</enddate><creator>Vargas, Jan, BS</creator><creator>Gowans, Mathew, BA</creator><creator>Vandergrift, William A., MD</creator><creator>Giglio, Pierre, MD</creator><creator>Hope, Jason, MD</creator><general>Elsevier Inc</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>20110201</creationdate><title>Metastatic Hepatocellular Carcinoma With Associated Spinal Cord Compression</title><author>Vargas, Jan, BS ; Gowans, Mathew, BA ; Vandergrift, William A., MD ; Giglio, Pierre, MD ; Hope, Jason, MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c478t-1d7d078ee61c0cd559ff0b6dd84b9f71c9d66df9197a40d6cf522b537a710c723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Biological and medical sciences</topic><topic>Carcinoma, Hepatocellular - complications</topic><topic>Carcinoma, Hepatocellular - diagnosis</topic><topic>Carcinoma, Hepatocellular - secondary</topic><topic>Cerebrospinal fluid. Meninges. Spinal cord</topic><topic>Epidural spinal cord compression</topic><topic>Fatal Outcome</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>General aspects</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Laminectomy</topic><topic>Liver Neoplasms - diagnosis</topic><topic>Liver. Biliary tract. Portal circulation. 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The prognosis is poor, with a survival time of months from the time of diagnosis. This article reports a case of myelopathy that developed from metastases in a patient with no significant medical history. The patient was treated with decompressive laminectomy followed by adjuvant radiotherapy. A review of the literature demonstrated that most cases from hepatocellular carcinoma metastasizing to the spinal cord involve either the thoracic or lumbar levels and arise from the right liver lobe or both lobes. Major risk factors included positive hepatitis B virus serologies. This article also discusses current trends in management of epidural spinal cord compression. Although treatment with chemotherapy has not shown any benefit, surgical management has been shown to decrease morbidity and mortality in some patients.</abstract><cop>Hagerstown, MD</cop><pub>Elsevier Inc</pub><pmid>21107234</pmid><doi>10.1097/MAJ.0b013e3181f7a49a</doi><tpages>5</tpages></addata></record> |
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| subjects | Biological and medical sciences Carcinoma, Hepatocellular - complications Carcinoma, Hepatocellular - diagnosis Carcinoma, Hepatocellular - secondary Cerebrospinal fluid. Meninges. Spinal cord Epidural spinal cord compression Fatal Outcome Gastroenterology. Liver. Pancreas. Abdomen General aspects Humans Internal Medicine Laminectomy Liver Neoplasms - diagnosis Liver. Biliary tract. Portal circulation. Exocrine pancreas Magnetic Resonance Imaging Male Medical sciences Metastatic hepatocellular carcinoma Middle Aged Nervous system (semeiology, syndromes) Neurology Spinal Cord Compression - diagnosis Spinal Cord Compression - etiology Spinal Cord Compression - surgery Spinal Cord Neoplasms - complications Spinal Cord Neoplasms - diagnosis Spinal Cord Neoplasms - secondary Spinal Cord Neoplasms - surgery Spine Tumors |
| title | Metastatic Hepatocellular Carcinoma With Associated Spinal Cord Compression |
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