Study of resistance to chemotherapy mediated by ABC transporters in biopsies of glioblastoma multiforme
Mortality rate is dramatically high in high grade brain tumors. The presence of multiple drug resistance transporters in glioblastoma multiforme, has contributed largely to the poor efficacy of targeted therapy against cancer in the central nervous system. To analyze the percentage of survival and m...
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| Veröffentlicht in: | Revista medíca de Chile 2011-04, Vol.139 (4), p.415-424 |
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| creator | Quezada, Claudia Peigñan, Lilia Segura, Rodrigo Riquelme, Francisco Melo, Rómulo Rojas Z, David Ayach, Freddy San Martín, Rody Cárcamo, Juan Guillermo |
| description | Mortality rate is dramatically high in high grade brain tumors. The presence of multiple drug resistance transporters in glioblastoma multiforme, has contributed largely to the poor efficacy of targeted therapy against cancer in the central nervous system.
To analyze the percentage of survival and mortality of patients with glioblastoma multiforme in a cohort of patients in Chile and to co-rrelate the chemo-resistance of these cells with the expression level of multiple drug resistance transporters.
Eighteen biopsies of glioblastoma multiforme were obtained from patients at the Institute of Neurosurgery Dr. Asenjo (INCA). The tumor cells were obtained from primary cultures and the expression and activity of multiple drug resistance transporters was assessed by RT-PCR and immunohistochemistry. Population-based study was performed using the databases of the Department of Neurosurgery of INCA.
The number of patients with glioblastoma multiforme increased between 2007 and 2009, from 3.5% to 7.9% of total brain tumors. Mortality of these tumors is 90 % at three years. A high expression and activity of the multiple drugs resistance associated protein 1 (Mrp1) transporter was observed in primary cultures of biopsies.
We propose that Mrp1 activity is responsible for the chemo-resistance of the glioblastoma multiforme and inhibition of this transporter could represent a plausible strategy for the treatment. |
| doi_str_mv | 10.4067/S0034-98872011000400001 |
| format | Article |
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To analyze the percentage of survival and mortality of patients with glioblastoma multiforme in a cohort of patients in Chile and to co-rrelate the chemo-resistance of these cells with the expression level of multiple drug resistance transporters.
Eighteen biopsies of glioblastoma multiforme were obtained from patients at the Institute of Neurosurgery Dr. Asenjo (INCA). The tumor cells were obtained from primary cultures and the expression and activity of multiple drug resistance transporters was assessed by RT-PCR and immunohistochemistry. Population-based study was performed using the databases of the Department of Neurosurgery of INCA.
The number of patients with glioblastoma multiforme increased between 2007 and 2009, from 3.5% to 7.9% of total brain tumors. Mortality of these tumors is 90 % at three years. A high expression and activity of the multiple drugs resistance associated protein 1 (Mrp1) transporter was observed in primary cultures of biopsies.
We propose that Mrp1 activity is responsible for the chemo-resistance of the glioblastoma multiforme and inhibition of this transporter could represent a plausible strategy for the treatment.</description><identifier>ISSN: 0034-9887</identifier><identifier>EISSN: 0717-6163</identifier><identifier>DOI: 10.4067/S0034-98872011000400001</identifier><identifier>PMID: 21879178</identifier><language>spa</language><publisher>Chile</publisher><subject>Adolescent ; Adult ; Aged ; ATP-Binding Cassette Transporters - metabolism ; Brain Neoplasms - drug therapy ; Brain Neoplasms - metabolism ; Brain Neoplasms - mortality ; Child ; Child, Preschool ; Cohort Studies ; Drug Resistance, Neoplasm ; Female ; Follow-Up Studies ; Glioblastoma - drug therapy ; Glioblastoma - metabolism ; Glioblastoma - mortality ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Neoplasm Proteins - metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Survival Analysis ; Tumor Cells, Cultured ; Young Adult</subject><ispartof>Revista medíca de Chile, 2011-04, Vol.139 (4), p.415-424</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21879178$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Quezada, Claudia</creatorcontrib><creatorcontrib>Peigñan, Lilia</creatorcontrib><creatorcontrib>Segura, Rodrigo</creatorcontrib><creatorcontrib>Riquelme, Francisco</creatorcontrib><creatorcontrib>Melo, Rómulo</creatorcontrib><creatorcontrib>Rojas Z, David</creatorcontrib><creatorcontrib>Ayach, Freddy</creatorcontrib><creatorcontrib>San Martín, Rody</creatorcontrib><creatorcontrib>Cárcamo, Juan Guillermo</creatorcontrib><title>Study of resistance to chemotherapy mediated by ABC transporters in biopsies of glioblastoma multiforme</title><title>Revista medíca de Chile</title><addtitle>Rev Med Chil</addtitle><description>Mortality rate is dramatically high in high grade brain tumors. The presence of multiple drug resistance transporters in glioblastoma multiforme, has contributed largely to the poor efficacy of targeted therapy against cancer in the central nervous system.
To analyze the percentage of survival and mortality of patients with glioblastoma multiforme in a cohort of patients in Chile and to co-rrelate the chemo-resistance of these cells with the expression level of multiple drug resistance transporters.
Eighteen biopsies of glioblastoma multiforme were obtained from patients at the Institute of Neurosurgery Dr. Asenjo (INCA). The tumor cells were obtained from primary cultures and the expression and activity of multiple drug resistance transporters was assessed by RT-PCR and immunohistochemistry. Population-based study was performed using the databases of the Department of Neurosurgery of INCA.
The number of patients with glioblastoma multiforme increased between 2007 and 2009, from 3.5% to 7.9% of total brain tumors. Mortality of these tumors is 90 % at three years. A high expression and activity of the multiple drugs resistance associated protein 1 (Mrp1) transporter was observed in primary cultures of biopsies.
We propose that Mrp1 activity is responsible for the chemo-resistance of the glioblastoma multiforme and inhibition of this transporter could represent a plausible strategy for the treatment.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>ATP-Binding Cassette Transporters - metabolism</subject><subject>Brain Neoplasms - drug therapy</subject><subject>Brain Neoplasms - metabolism</subject><subject>Brain Neoplasms - mortality</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cohort Studies</subject><subject>Drug Resistance, Neoplasm</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Glioblastoma - drug therapy</subject><subject>Glioblastoma - metabolism</subject><subject>Glioblastoma - mortality</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasm Proteins - metabolism</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Survival Analysis</subject><subject>Tumor Cells, Cultured</subject><subject>Young Adult</subject><issn>0034-9887</issn><issn>0717-6163</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkDtPwzAUhS0EoqXwF8AbU-DaTvwYS8VLqsRQmCMndlqjJA62M-TfE0SZGa7OHT4d6XwI3RC4y4GL-x0AyzMlpaBACADk8wE5QUsQRGSccHY6_3_QAl3E-AlABSfyHC0okUIRIZdov0ujmbBvcLDRxaT72uLkcX2wnU8HG_Qw4c4ap5M1uJrw-mGDU9B9HHxINkTselw5P0Rn40_NvnW-anVMvtO4G9vkGh86e4nOGt1Ge3XMFfp4enzfvGTbt-fXzXqbDUTQlDEjhJQVo40CznMLREkhjVY1M4U0IKWdtwkCllU0F4WpuKS54gXVTd2Yiq3Q7W_vEPzXaGMqOxdr27a6t36MpaKMqFkD_5eUkivCQRUzeX0kx2pWUQ7BdTpM5Z9F9g2BUnYj</recordid><startdate>201104</startdate><enddate>201104</enddate><creator>Quezada, Claudia</creator><creator>Peigñan, Lilia</creator><creator>Segura, Rodrigo</creator><creator>Riquelme, Francisco</creator><creator>Melo, Rómulo</creator><creator>Rojas Z, David</creator><creator>Ayach, Freddy</creator><creator>San Martín, Rody</creator><creator>Cárcamo, Juan Guillermo</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>201104</creationdate><title>Study of resistance to chemotherapy mediated by ABC transporters in biopsies of glioblastoma multiforme</title><author>Quezada, Claudia ; Peigñan, Lilia ; Segura, Rodrigo ; Riquelme, Francisco ; Melo, Rómulo ; Rojas Z, David ; Ayach, Freddy ; San Martín, Rody ; Cárcamo, Juan Guillermo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p172t-3d7788b32f90664e019878da9c3d58d088e616710e3b2475db68249652afcfdb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>spa</language><creationdate>2011</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>ATP-Binding Cassette Transporters - metabolism</topic><topic>Brain Neoplasms - drug therapy</topic><topic>Brain Neoplasms - metabolism</topic><topic>Brain Neoplasms - mortality</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cohort Studies</topic><topic>Drug Resistance, Neoplasm</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Glioblastoma - drug therapy</topic><topic>Glioblastoma - metabolism</topic><topic>Glioblastoma - mortality</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasm Proteins - metabolism</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>Survival Analysis</topic><topic>Tumor Cells, Cultured</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Quezada, Claudia</creatorcontrib><creatorcontrib>Peigñan, Lilia</creatorcontrib><creatorcontrib>Segura, Rodrigo</creatorcontrib><creatorcontrib>Riquelme, Francisco</creatorcontrib><creatorcontrib>Melo, Rómulo</creatorcontrib><creatorcontrib>Rojas Z, David</creatorcontrib><creatorcontrib>Ayach, Freddy</creatorcontrib><creatorcontrib>San Martín, Rody</creatorcontrib><creatorcontrib>Cárcamo, Juan Guillermo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Revista medíca de Chile</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Quezada, Claudia</au><au>Peigñan, Lilia</au><au>Segura, Rodrigo</au><au>Riquelme, Francisco</au><au>Melo, Rómulo</au><au>Rojas Z, David</au><au>Ayach, Freddy</au><au>San Martín, Rody</au><au>Cárcamo, Juan Guillermo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Study of resistance to chemotherapy mediated by ABC transporters in biopsies of glioblastoma multiforme</atitle><jtitle>Revista medíca de Chile</jtitle><addtitle>Rev Med Chil</addtitle><date>2011-04</date><risdate>2011</risdate><volume>139</volume><issue>4</issue><spage>415</spage><epage>424</epage><pages>415-424</pages><issn>0034-9887</issn><eissn>0717-6163</eissn><abstract>Mortality rate is dramatically high in high grade brain tumors. The presence of multiple drug resistance transporters in glioblastoma multiforme, has contributed largely to the poor efficacy of targeted therapy against cancer in the central nervous system.
To analyze the percentage of survival and mortality of patients with glioblastoma multiforme in a cohort of patients in Chile and to co-rrelate the chemo-resistance of these cells with the expression level of multiple drug resistance transporters.
Eighteen biopsies of glioblastoma multiforme were obtained from patients at the Institute of Neurosurgery Dr. Asenjo (INCA). The tumor cells were obtained from primary cultures and the expression and activity of multiple drug resistance transporters was assessed by RT-PCR and immunohistochemistry. Population-based study was performed using the databases of the Department of Neurosurgery of INCA.
The number of patients with glioblastoma multiforme increased between 2007 and 2009, from 3.5% to 7.9% of total brain tumors. Mortality of these tumors is 90 % at three years. A high expression and activity of the multiple drugs resistance associated protein 1 (Mrp1) transporter was observed in primary cultures of biopsies.
We propose that Mrp1 activity is responsible for the chemo-resistance of the glioblastoma multiforme and inhibition of this transporter could represent a plausible strategy for the treatment.</abstract><cop>Chile</cop><pmid>21879178</pmid><doi>10.4067/S0034-98872011000400001</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Aged ATP-Binding Cassette Transporters - metabolism Brain Neoplasms - drug therapy Brain Neoplasms - metabolism Brain Neoplasms - mortality Child Child, Preschool Cohort Studies Drug Resistance, Neoplasm Female Follow-Up Studies Glioblastoma - drug therapy Glioblastoma - metabolism Glioblastoma - mortality Humans Immunohistochemistry Male Middle Aged Neoplasm Proteins - metabolism Reverse Transcriptase Polymerase Chain Reaction Survival Analysis Tumor Cells, Cultured Young Adult |
| title | Study of resistance to chemotherapy mediated by ABC transporters in biopsies of glioblastoma multiforme |
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