Specific Celiac Disease Antibodies in Children on a Gluten-Free Diet
Celiac disease (CD) is characterized by histologic alterations in small bowel biopsies. Circulating specific CD antibodies at the time of diagnosis and their disappearance after a gluten-free diet support the diagnosis of CD. We aimed to determine the behavior of the CD antibodies immunoglobulin A a...
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| Veröffentlicht in: | Pediatrics (Evanston) 2011-09, Vol.128 (3), p.547-552 |
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| creator | HOGEN ESCH, Caroline E WOLTERS, Victorien M GERRITSEN, Susan A. M PUTTER, Hein MARY VON BLOMBERG, B VAN HOOGSTRATEN, Ingrid M. W HOUWEN, Roderick H. J DER LELY, Nico Van LUISA MEARIN, M |
| description | Celiac disease (CD) is characterized by histologic alterations in small bowel biopsies. Circulating specific CD antibodies at the time of diagnosis and their disappearance after a gluten-free diet support the diagnosis of CD. We aimed to determine the behavior of the CD antibodies immunoglobulin A anti-tissue transglutaminase (anti-TG2) and immunoglobulin A endomysium (EMA) in children with CD after starting a gluten-free diet.
This was a retrospective multicenter study in the Netherlands between 2001 and 2009. Inclusion criteria were all newly diagnosed patients with CD younger than 19 years who had at least 1 anti-TG2 and/or EMA measurement before and after starting a gluten-free diet. Eight different anti-TG2 kits were used with substrates of guinea pig TG2 in 1 (Sigma) and 7 human-recombinant TG2: Varelisa and EliA Celikey Phadia-GmbH; Orgentec Diagnostica-GmbH; Diarect AG; Roboscreen GmbH; Aeskulisa Diagnostics; Binding Site Ltd. EMA was analyzed with indirect immunofluorescence tests. Statistical analyses were performed by using mixed-model repeated measurements and survival analysis.
There were 129 children with CD included (mean age: 5.6 years; SD ± 4.2). The mean concentration of anti-TG2 decreased significantly within 3 months after starting a gluten-free diet (P < .0001). The cumulative percentage of children who became negative for EMA after ½, 1, 1½, and 2 years was 31%, 60%, 74%, and 87%, respectively. For anti-TG2, a comparable trend was shown: 35%, 55%, 64%, and 78%, respectively.
Doctors taking care of children with CD should be aware that the mean concentration of anti-TG2 will show a 74% decrease (95% confidence interval: 69%-79%) after 3 months of gluten-free diet, and ∼80% of the children will be sero-negative for EMA and anti-TG2 after 2 years of the diet. |
| doi_str_mv | 10.1542/peds.2010-3762 |
| format | Article |
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This was a retrospective multicenter study in the Netherlands between 2001 and 2009. Inclusion criteria were all newly diagnosed patients with CD younger than 19 years who had at least 1 anti-TG2 and/or EMA measurement before and after starting a gluten-free diet. Eight different anti-TG2 kits were used with substrates of guinea pig TG2 in 1 (Sigma) and 7 human-recombinant TG2: Varelisa and EliA Celikey Phadia-GmbH; Orgentec Diagnostica-GmbH; Diarect AG; Roboscreen GmbH; Aeskulisa Diagnostics; Binding Site Ltd. EMA was analyzed with indirect immunofluorescence tests. Statistical analyses were performed by using mixed-model repeated measurements and survival analysis.
There were 129 children with CD included (mean age: 5.6 years; SD ± 4.2). The mean concentration of anti-TG2 decreased significantly within 3 months after starting a gluten-free diet (P < .0001). The cumulative percentage of children who became negative for EMA after ½, 1, 1½, and 2 years was 31%, 60%, 74%, and 87%, respectively. For anti-TG2, a comparable trend was shown: 35%, 55%, 64%, and 78%, respectively.
Doctors taking care of children with CD should be aware that the mean concentration of anti-TG2 will show a 74% decrease (95% confidence interval: 69%-79%) after 3 months of gluten-free diet, and ∼80% of the children will be sero-negative for EMA and anti-TG2 after 2 years of the diet.</description><identifier>ISSN: 0031-4005</identifier><identifier>EISSN: 1098-4275</identifier><identifier>DOI: 10.1542/peds.2010-3762</identifier><identifier>PMID: 21859913</identifier><identifier>CODEN: PEDIAU</identifier><language>eng</language><publisher>Elk Grove Village, IL: American Academy of Pediatrics</publisher><subject>Antibodies, Anti-Idiotypic - immunology ; Autoantibodies - immunology ; Biological and medical sciences ; Care and treatment ; Celiac disease ; Celiac Disease - diet therapy ; Celiac Disease - immunology ; Child ; Child, Preschool ; Childrens health ; Demographic aspects ; Diet ; Diet, Gluten-Free ; Female ; Fluorescent Antibody Technique, Indirect ; Gastroenterology. Liver. Pancreas. Abdomen ; General aspects ; Gluten-free diet ; GTP-Binding Proteins - immunology ; Humans ; Immunoglobulin A ; Immunoglobulin A - immunology ; Immunoglobulins ; Infant ; Intestinal Mucosa - immunology ; Male ; Measurement ; Medical sciences ; Other diseases. Semiology ; Patient outcomes ; Pediatrics ; Retrospective Studies ; Rodents ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Transglutaminases ; Transglutaminases - immunology</subject><ispartof>Pediatrics (Evanston), 2011-09, Vol.128 (3), p.547-552</ispartof><rights>2015 INIST-CNRS</rights><rights>Copyright American Academy of Pediatrics Sep 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-3e82bfab2ae3ec192945b9fce233c7641e74799091af4f229b1d17fe38638bb33</citedby><cites>FETCH-LOGICAL-c389t-3e82bfab2ae3ec192945b9fce233c7641e74799091af4f229b1d17fe38638bb33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24468933$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21859913$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HOGEN ESCH, Caroline E</creatorcontrib><creatorcontrib>WOLTERS, Victorien M</creatorcontrib><creatorcontrib>GERRITSEN, Susan A. M</creatorcontrib><creatorcontrib>PUTTER, Hein</creatorcontrib><creatorcontrib>MARY VON BLOMBERG, B</creatorcontrib><creatorcontrib>VAN HOOGSTRATEN, Ingrid M. W</creatorcontrib><creatorcontrib>HOUWEN, Roderick H. J</creatorcontrib><creatorcontrib>DER LELY, Nico Van</creatorcontrib><creatorcontrib>LUISA MEARIN, M</creatorcontrib><title>Specific Celiac Disease Antibodies in Children on a Gluten-Free Diet</title><title>Pediatrics (Evanston)</title><addtitle>Pediatrics</addtitle><description>Celiac disease (CD) is characterized by histologic alterations in small bowel biopsies. Circulating specific CD antibodies at the time of diagnosis and their disappearance after a gluten-free diet support the diagnosis of CD. We aimed to determine the behavior of the CD antibodies immunoglobulin A anti-tissue transglutaminase (anti-TG2) and immunoglobulin A endomysium (EMA) in children with CD after starting a gluten-free diet.
This was a retrospective multicenter study in the Netherlands between 2001 and 2009. Inclusion criteria were all newly diagnosed patients with CD younger than 19 years who had at least 1 anti-TG2 and/or EMA measurement before and after starting a gluten-free diet. Eight different anti-TG2 kits were used with substrates of guinea pig TG2 in 1 (Sigma) and 7 human-recombinant TG2: Varelisa and EliA Celikey Phadia-GmbH; Orgentec Diagnostica-GmbH; Diarect AG; Roboscreen GmbH; Aeskulisa Diagnostics; Binding Site Ltd. EMA was analyzed with indirect immunofluorescence tests. Statistical analyses were performed by using mixed-model repeated measurements and survival analysis.
There were 129 children with CD included (mean age: 5.6 years; SD ± 4.2). The mean concentration of anti-TG2 decreased significantly within 3 months after starting a gluten-free diet (P < .0001). The cumulative percentage of children who became negative for EMA after ½, 1, 1½, and 2 years was 31%, 60%, 74%, and 87%, respectively. For anti-TG2, a comparable trend was shown: 35%, 55%, 64%, and 78%, respectively.
Doctors taking care of children with CD should be aware that the mean concentration of anti-TG2 will show a 74% decrease (95% confidence interval: 69%-79%) after 3 months of gluten-free diet, and ∼80% of the children will be sero-negative for EMA and anti-TG2 after 2 years of the diet.</description><subject>Antibodies, Anti-Idiotypic - immunology</subject><subject>Autoantibodies - immunology</subject><subject>Biological and medical sciences</subject><subject>Care and treatment</subject><subject>Celiac disease</subject><subject>Celiac Disease - diet therapy</subject><subject>Celiac Disease - immunology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Childrens health</subject><subject>Demographic aspects</subject><subject>Diet</subject><subject>Diet, Gluten-Free</subject><subject>Female</subject><subject>Fluorescent Antibody Technique, Indirect</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>General aspects</subject><subject>Gluten-free diet</subject><subject>GTP-Binding Proteins - immunology</subject><subject>Humans</subject><subject>Immunoglobulin A</subject><subject>Immunoglobulin A - immunology</subject><subject>Immunoglobulins</subject><subject>Infant</subject><subject>Intestinal Mucosa - immunology</subject><subject>Male</subject><subject>Measurement</subject><subject>Medical sciences</subject><subject>Other diseases. Semiology</subject><subject>Patient outcomes</subject><subject>Pediatrics</subject><subject>Retrospective Studies</subject><subject>Rodents</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. 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Abdomen</topic><topic>General aspects</topic><topic>Gluten-free diet</topic><topic>GTP-Binding Proteins - immunology</topic><topic>Humans</topic><topic>Immunoglobulin A</topic><topic>Immunoglobulin A - immunology</topic><topic>Immunoglobulins</topic><topic>Infant</topic><topic>Intestinal Mucosa - immunology</topic><topic>Male</topic><topic>Measurement</topic><topic>Medical sciences</topic><topic>Other diseases. Semiology</topic><topic>Patient outcomes</topic><topic>Pediatrics</topic><topic>Retrospective Studies</topic><topic>Rodents</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Transglutaminases</topic><topic>Transglutaminases - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HOGEN ESCH, Caroline E</creatorcontrib><creatorcontrib>WOLTERS, Victorien M</creatorcontrib><creatorcontrib>GERRITSEN, Susan A. 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M</au><au>PUTTER, Hein</au><au>MARY VON BLOMBERG, B</au><au>VAN HOOGSTRATEN, Ingrid M. W</au><au>HOUWEN, Roderick H. J</au><au>DER LELY, Nico Van</au><au>LUISA MEARIN, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Specific Celiac Disease Antibodies in Children on a Gluten-Free Diet</atitle><jtitle>Pediatrics (Evanston)</jtitle><addtitle>Pediatrics</addtitle><date>2011-09-01</date><risdate>2011</risdate><volume>128</volume><issue>3</issue><spage>547</spage><epage>552</epage><pages>547-552</pages><issn>0031-4005</issn><eissn>1098-4275</eissn><coden>PEDIAU</coden><abstract>Celiac disease (CD) is characterized by histologic alterations in small bowel biopsies. Circulating specific CD antibodies at the time of diagnosis and their disappearance after a gluten-free diet support the diagnosis of CD. We aimed to determine the behavior of the CD antibodies immunoglobulin A anti-tissue transglutaminase (anti-TG2) and immunoglobulin A endomysium (EMA) in children with CD after starting a gluten-free diet.
This was a retrospective multicenter study in the Netherlands between 2001 and 2009. Inclusion criteria were all newly diagnosed patients with CD younger than 19 years who had at least 1 anti-TG2 and/or EMA measurement before and after starting a gluten-free diet. Eight different anti-TG2 kits were used with substrates of guinea pig TG2 in 1 (Sigma) and 7 human-recombinant TG2: Varelisa and EliA Celikey Phadia-GmbH; Orgentec Diagnostica-GmbH; Diarect AG; Roboscreen GmbH; Aeskulisa Diagnostics; Binding Site Ltd. EMA was analyzed with indirect immunofluorescence tests. Statistical analyses were performed by using mixed-model repeated measurements and survival analysis.
There were 129 children with CD included (mean age: 5.6 years; SD ± 4.2). The mean concentration of anti-TG2 decreased significantly within 3 months after starting a gluten-free diet (P < .0001). The cumulative percentage of children who became negative for EMA after ½, 1, 1½, and 2 years was 31%, 60%, 74%, and 87%, respectively. For anti-TG2, a comparable trend was shown: 35%, 55%, 64%, and 78%, respectively.
Doctors taking care of children with CD should be aware that the mean concentration of anti-TG2 will show a 74% decrease (95% confidence interval: 69%-79%) after 3 months of gluten-free diet, and ∼80% of the children will be sero-negative for EMA and anti-TG2 after 2 years of the diet.</abstract><cop>Elk Grove Village, IL</cop><pub>American Academy of Pediatrics</pub><pmid>21859913</pmid><doi>10.1542/peds.2010-3762</doi><tpages>6</tpages></addata></record> |
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| subjects | Antibodies, Anti-Idiotypic - immunology Autoantibodies - immunology Biological and medical sciences Care and treatment Celiac disease Celiac Disease - diet therapy Celiac Disease - immunology Child Child, Preschool Childrens health Demographic aspects Diet Diet, Gluten-Free Female Fluorescent Antibody Technique, Indirect Gastroenterology. Liver. Pancreas. Abdomen General aspects Gluten-free diet GTP-Binding Proteins - immunology Humans Immunoglobulin A Immunoglobulin A - immunology Immunoglobulins Infant Intestinal Mucosa - immunology Male Measurement Medical sciences Other diseases. Semiology Patient outcomes Pediatrics Retrospective Studies Rodents Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Transglutaminases Transglutaminases - immunology |
| title | Specific Celiac Disease Antibodies in Children on a Gluten-Free Diet |
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