Is Aortic Atherothrombotic Disease Detected Using Multidetector-Row CT Associated With an Increased Risk of Early Ischemic Lesion Recurrence After Acute Ischemic Stroke?
Multidetector-row CT (MDCT) is emerging as a new tool for diagnosing aortic atherothrombotic disease (AAD). We elucidated whether MDCT-detected AAD is associated with an increased risk of early ischemic lesion recurrence on diffusion-weighted MRI after ischemic stroke. A consecutive series of patien...
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| Veröffentlicht in: | Stroke (1970) 2012-03, Vol.43 (3), p.764-769 |
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| container_title | Stroke (1970) |
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| creator | KO, Youngchai KIM, Wook-Joo MYUNG SUK JANG MI HWA YANG JUNG HYUN PARK SANG IL CHOI EUN JU CHUN SOO JOO LEE HAN, Moon-Ku BAE, Hee-Joon |
| description | Multidetector-row CT (MDCT) is emerging as a new tool for diagnosing aortic atherothrombotic disease (AAD). We elucidated whether MDCT-detected AAD is associated with an increased risk of early ischemic lesion recurrence on diffusion-weighted MRI after ischemic stroke.
A consecutive series of patients with acute ischemic stroke confirmed using diffusion-weighted MRI who were hospitalized within 48 hours after symptom onset and underwent MDCT were identified in a prospective stroke registry database. AAD on MDCT was defined as the presence of plaque formation that was noncalcified and ≥4 mm thick, ulcerative, or soft and thrombosed (vulnerable) in the proximal aortic arch. Ischemic lesion recurrence on diffusion-weighted MRI was defined as the occurrence of any new lesion separate from the index lesion on follow-up diffusion-weighted MRI performed within 14 days after symptom onset.
A total of 138 patients was selected. MDCT detected AAD in 24 of 138 (17.4%); ≥4 mm thickness in 17 of 138 (12.3%); ulcerated plaque in 20 of 138 (14.5%); and vulnerable plaque in 16 of 138 (11.6%). With respect to diffusion-weighted MRI lesion recurrence, the crude ORs (95% CIs) were as follows: AAD, 3.56 (1.43-8.89); vulnerable plaque, 3.21 (1.11-9.30); ulcerated plaque, 3.37 (1.27-8.95); and ≥4 mm thickness of the noncalcified plaque, 4.23 (1.11-16.19). These results remained significant after adjustments for potential confounders were made.
This study shows that AAD detected by MDCT increases the risk of early ischemic lesion recurrence after acute ischemic stroke, thus supporting the role of MDCT in diagnosing AAD and assessing its contribution to recurrence. |
| doi_str_mv | 10.1161/STROKEAHA.111.632182 |
| format | Article |
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A consecutive series of patients with acute ischemic stroke confirmed using diffusion-weighted MRI who were hospitalized within 48 hours after symptom onset and underwent MDCT were identified in a prospective stroke registry database. AAD on MDCT was defined as the presence of plaque formation that was noncalcified and ≥4 mm thick, ulcerative, or soft and thrombosed (vulnerable) in the proximal aortic arch. Ischemic lesion recurrence on diffusion-weighted MRI was defined as the occurrence of any new lesion separate from the index lesion on follow-up diffusion-weighted MRI performed within 14 days after symptom onset.
A total of 138 patients was selected. MDCT detected AAD in 24 of 138 (17.4%); ≥4 mm thickness in 17 of 138 (12.3%); ulcerated plaque in 20 of 138 (14.5%); and vulnerable plaque in 16 of 138 (11.6%). With respect to diffusion-weighted MRI lesion recurrence, the crude ORs (95% CIs) were as follows: AAD, 3.56 (1.43-8.89); vulnerable plaque, 3.21 (1.11-9.30); ulcerated plaque, 3.37 (1.27-8.95); and ≥4 mm thickness of the noncalcified plaque, 4.23 (1.11-16.19). These results remained significant after adjustments for potential confounders were made.
This study shows that AAD detected by MDCT increases the risk of early ischemic lesion recurrence after acute ischemic stroke, thus supporting the role of MDCT in diagnosing AAD and assessing its contribution to recurrence.</description><identifier>ISSN: 0039-2499</identifier><identifier>EISSN: 1524-4628</identifier><identifier>DOI: 10.1161/STROKEAHA.111.632182</identifier><identifier>PMID: 22282886</identifier><identifier>CODEN: SJCCA7</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Aged ; Biological and medical sciences ; Blood. Blood coagulation. Reticuloendothelial system ; Brain Ischemia - complications ; Brain Ischemia - epidemiology ; Diffusion Magnetic Resonance Imaging ; Female ; Follow-Up Studies ; Humans ; Image Processing, Computer-Assisted ; Intracranial Thrombosis - complications ; Intracranial Thrombosis - diagnostic imaging ; Male ; Medical sciences ; Middle Aged ; Neurology ; Pharmacology. Drug treatments ; Recurrence ; Risk ; Stroke - epidemiology ; Stroke - etiology ; Tomography, X-Ray Computed ; Treatment Outcome ; Vascular diseases and vascular malformations of the nervous system</subject><ispartof>Stroke (1970), 2012-03, Vol.43 (3), p.764-769</ispartof><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c382t-8d14d3d3b222970d034a1f48ca9ef46ad3f4de2eb88eb92a223c8db8c1479f3a3</citedby><cites>FETCH-LOGICAL-c382t-8d14d3d3b222970d034a1f48ca9ef46ad3f4de2eb88eb92a223c8db8c1479f3a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3674,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25567498$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22282886$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KO, Youngchai</creatorcontrib><creatorcontrib>KIM, Wook-Joo</creatorcontrib><creatorcontrib>MYUNG SUK JANG</creatorcontrib><creatorcontrib>MI HWA YANG</creatorcontrib><creatorcontrib>JUNG HYUN PARK</creatorcontrib><creatorcontrib>SANG IL CHOI</creatorcontrib><creatorcontrib>EUN JU CHUN</creatorcontrib><creatorcontrib>SOO JOO LEE</creatorcontrib><creatorcontrib>HAN, Moon-Ku</creatorcontrib><creatorcontrib>BAE, Hee-Joon</creatorcontrib><title>Is Aortic Atherothrombotic Disease Detected Using Multidetector-Row CT Associated With an Increased Risk of Early Ischemic Lesion Recurrence After Acute Ischemic Stroke?</title><title>Stroke (1970)</title><addtitle>Stroke</addtitle><description>Multidetector-row CT (MDCT) is emerging as a new tool for diagnosing aortic atherothrombotic disease (AAD). We elucidated whether MDCT-detected AAD is associated with an increased risk of early ischemic lesion recurrence on diffusion-weighted MRI after ischemic stroke.
A consecutive series of patients with acute ischemic stroke confirmed using diffusion-weighted MRI who were hospitalized within 48 hours after symptom onset and underwent MDCT were identified in a prospective stroke registry database. AAD on MDCT was defined as the presence of plaque formation that was noncalcified and ≥4 mm thick, ulcerative, or soft and thrombosed (vulnerable) in the proximal aortic arch. Ischemic lesion recurrence on diffusion-weighted MRI was defined as the occurrence of any new lesion separate from the index lesion on follow-up diffusion-weighted MRI performed within 14 days after symptom onset.
A total of 138 patients was selected. MDCT detected AAD in 24 of 138 (17.4%); ≥4 mm thickness in 17 of 138 (12.3%); ulcerated plaque in 20 of 138 (14.5%); and vulnerable plaque in 16 of 138 (11.6%). With respect to diffusion-weighted MRI lesion recurrence, the crude ORs (95% CIs) were as follows: AAD, 3.56 (1.43-8.89); vulnerable plaque, 3.21 (1.11-9.30); ulcerated plaque, 3.37 (1.27-8.95); and ≥4 mm thickness of the noncalcified plaque, 4.23 (1.11-16.19). These results remained significant after adjustments for potential confounders were made.
This study shows that AAD detected by MDCT increases the risk of early ischemic lesion recurrence after acute ischemic stroke, thus supporting the role of MDCT in diagnosing AAD and assessing its contribution to recurrence.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Blood. Blood coagulation. Reticuloendothelial system</subject><subject>Brain Ischemia - complications</subject><subject>Brain Ischemia - epidemiology</subject><subject>Diffusion Magnetic Resonance Imaging</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted</subject><subject>Intracranial Thrombosis - complications</subject><subject>Intracranial Thrombosis - diagnostic imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>Pharmacology. Drug treatments</subject><subject>Recurrence</subject><subject>Risk</subject><subject>Stroke - epidemiology</subject><subject>Stroke - etiology</subject><subject>Tomography, X-Ray Computed</subject><subject>Treatment Outcome</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><issn>0039-2499</issn><issn>1524-4628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkd1u00AQhVcIREPLGyC0N4grl_2Lvb5CVprSiKBKaapeWuvdMVlqe8vOWlUfibfEIaG9Gp3Rd85odAj5wNk55zn_crPdXH9fVlfVJPl5LgXX4hWZ8blQmcqFfk1mjMkyE6osT8g7xF-MMSH1_C05EUJooXU-I39WSKsQk7e0SjuIIe1i6JuwX1x4BINALyCBTeDoLfrhJ_0xdsm7f7sQs014pIstrRCD9WZP3fm0o2agq8HGvd_Rjcd7Glq6NLF7oiu0O-in_DWgDwPdgB1jhMECrdoEkVZ2TPCC3aQY7uHrGXnTmg7h_XGektvL5XZxla2vv60W1TqzUouUaceVk042049lwRyTyvBWaWtKaFVunGyVAwGN1tCUwgghrXaNtlwVZSuNPCWfD7kPMfweAVPde7TQdWaAMGJdClHkUhZsItWBtDEgRmjrh-h7E59qzup9R_VzR5Pk9aGjyfbxeGBsenDPpv-lTMCnI2DQmq6NZrAeX7j5PC9UqeVfJC6dVA</recordid><startdate>20120301</startdate><enddate>20120301</enddate><creator>KO, Youngchai</creator><creator>KIM, Wook-Joo</creator><creator>MYUNG SUK JANG</creator><creator>MI HWA YANG</creator><creator>JUNG HYUN PARK</creator><creator>SANG IL CHOI</creator><creator>EUN JU CHUN</creator><creator>SOO JOO LEE</creator><creator>HAN, Moon-Ku</creator><creator>BAE, Hee-Joon</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120301</creationdate><title>Is Aortic Atherothrombotic Disease Detected Using Multidetector-Row CT Associated With an Increased Risk of Early Ischemic Lesion Recurrence After Acute Ischemic Stroke?</title><author>KO, Youngchai ; KIM, Wook-Joo ; MYUNG SUK JANG ; MI HWA YANG ; JUNG HYUN PARK ; SANG IL CHOI ; EUN JU CHUN ; SOO JOO LEE ; HAN, Moon-Ku ; BAE, Hee-Joon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c382t-8d14d3d3b222970d034a1f48ca9ef46ad3f4de2eb88eb92a223c8db8c1479f3a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Blood. Blood coagulation. Reticuloendothelial system</topic><topic>Brain Ischemia - complications</topic><topic>Brain Ischemia - epidemiology</topic><topic>Diffusion Magnetic Resonance Imaging</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted</topic><topic>Intracranial Thrombosis - complications</topic><topic>Intracranial Thrombosis - diagnostic imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>Pharmacology. Drug treatments</topic><topic>Recurrence</topic><topic>Risk</topic><topic>Stroke - epidemiology</topic><topic>Stroke - etiology</topic><topic>Tomography, X-Ray Computed</topic><topic>Treatment Outcome</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KO, Youngchai</creatorcontrib><creatorcontrib>KIM, Wook-Joo</creatorcontrib><creatorcontrib>MYUNG SUK JANG</creatorcontrib><creatorcontrib>MI HWA YANG</creatorcontrib><creatorcontrib>JUNG HYUN PARK</creatorcontrib><creatorcontrib>SANG IL CHOI</creatorcontrib><creatorcontrib>EUN JU CHUN</creatorcontrib><creatorcontrib>SOO JOO LEE</creatorcontrib><creatorcontrib>HAN, Moon-Ku</creatorcontrib><creatorcontrib>BAE, Hee-Joon</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Stroke (1970)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KO, Youngchai</au><au>KIM, Wook-Joo</au><au>MYUNG SUK JANG</au><au>MI HWA YANG</au><au>JUNG HYUN PARK</au><au>SANG IL CHOI</au><au>EUN JU CHUN</au><au>SOO JOO LEE</au><au>HAN, Moon-Ku</au><au>BAE, Hee-Joon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Is Aortic Atherothrombotic Disease Detected Using Multidetector-Row CT Associated With an Increased Risk of Early Ischemic Lesion Recurrence After Acute Ischemic Stroke?</atitle><jtitle>Stroke (1970)</jtitle><addtitle>Stroke</addtitle><date>2012-03-01</date><risdate>2012</risdate><volume>43</volume><issue>3</issue><spage>764</spage><epage>769</epage><pages>764-769</pages><issn>0039-2499</issn><eissn>1524-4628</eissn><coden>SJCCA7</coden><abstract>Multidetector-row CT (MDCT) is emerging as a new tool for diagnosing aortic atherothrombotic disease (AAD). We elucidated whether MDCT-detected AAD is associated with an increased risk of early ischemic lesion recurrence on diffusion-weighted MRI after ischemic stroke.
A consecutive series of patients with acute ischemic stroke confirmed using diffusion-weighted MRI who were hospitalized within 48 hours after symptom onset and underwent MDCT were identified in a prospective stroke registry database. AAD on MDCT was defined as the presence of plaque formation that was noncalcified and ≥4 mm thick, ulcerative, or soft and thrombosed (vulnerable) in the proximal aortic arch. Ischemic lesion recurrence on diffusion-weighted MRI was defined as the occurrence of any new lesion separate from the index lesion on follow-up diffusion-weighted MRI performed within 14 days after symptom onset.
A total of 138 patients was selected. MDCT detected AAD in 24 of 138 (17.4%); ≥4 mm thickness in 17 of 138 (12.3%); ulcerated plaque in 20 of 138 (14.5%); and vulnerable plaque in 16 of 138 (11.6%). With respect to diffusion-weighted MRI lesion recurrence, the crude ORs (95% CIs) were as follows: AAD, 3.56 (1.43-8.89); vulnerable plaque, 3.21 (1.11-9.30); ulcerated plaque, 3.37 (1.27-8.95); and ≥4 mm thickness of the noncalcified plaque, 4.23 (1.11-16.19). These results remained significant after adjustments for potential confounders were made.
This study shows that AAD detected by MDCT increases the risk of early ischemic lesion recurrence after acute ischemic stroke, thus supporting the role of MDCT in diagnosing AAD and assessing its contribution to recurrence.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>22282886</pmid><doi>10.1161/STROKEAHA.111.632182</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; American Heart Association Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection; Journals@Ovid Complete |
| subjects | Aged Biological and medical sciences Blood. Blood coagulation. Reticuloendothelial system Brain Ischemia - complications Brain Ischemia - epidemiology Diffusion Magnetic Resonance Imaging Female Follow-Up Studies Humans Image Processing, Computer-Assisted Intracranial Thrombosis - complications Intracranial Thrombosis - diagnostic imaging Male Medical sciences Middle Aged Neurology Pharmacology. Drug treatments Recurrence Risk Stroke - epidemiology Stroke - etiology Tomography, X-Ray Computed Treatment Outcome Vascular diseases and vascular malformations of the nervous system |
| title | Is Aortic Atherothrombotic Disease Detected Using Multidetector-Row CT Associated With an Increased Risk of Early Ischemic Lesion Recurrence After Acute Ischemic Stroke? |
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