Metallothionein-dependent up-regulation of TGF-β2 participates in the remodelling of the myxomatous mitral valve

Aims Although an excessive extracellular matrix remodelling has been well described in myxomatous mitral valve (MMV), the underlying pathogenic mechanisms remain largely unknown. Our goal was to identify dysregulated genes in human MMV and then to evaluate their functional role in the progression of...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cardiovascular research 2012-03, Vol.93 (3), p.480-489
Hauptverfasser:	Hulin, Alexia, Deroanne, Christophe F., Lambert, Charles A., Dumont, Bruno, Castronovo, Vincent, Defraigne, Jean-Olivier, Nusgens, Betty V., Radermecker, Marc A., Colige, Alain C.
Format:	Artikel
Sprache:	eng
Schlagworte:	ADAM Proteins - genetics ADAM Proteins - metabolism ADAMTS1 Protein Adult Aged Cells, Cultured Female Humans Male Metallothionein - genetics Metallothionein - metabolism Microarray Analysis Middle Aged Mitral Valve - metabolism Mitral Valve Insufficiency - metabolism Mitral Valve Insufficiency - physiopathology Transforming Growth Factor beta1 - genetics Transforming Growth Factor beta1 - metabolism Transforming Growth Factor beta2 - genetics Transforming Growth Factor beta2 - metabolism Up-Regulation - physiology Ventricular Remodeling - physiology Versicans - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!