Synthesis and evaluation of anti-tubercular and antibacterial activities of new 4-(2,6-dichlorobenzyloxy)phenyl thiazole, oxazole and imidazole derivatives. Part 2

A series of substituted 4-(2,6-dichlorobenzyloxy)phenyl thiazole, oxazole and imidazole derivatives were synthesized. The derivatives were screened for in vitro anti-tubercular activities against Mycobacterium tuberculosis H37Rv using the Microplate Alamar Blue Assay (MABA), and antibacterial activi...

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Veröffentlicht in:	European journal of medicinal chemistry 2012-03, Vol.49, p.164-171
Hauptverfasser:	Lu, Xiaoyun, Liu, Xiaobo, Wan, Baojie, Franzblau, Scott G., Chen, Lili, Zhou, Changlin, You, Qidong
Format:	Artikel
Sprache:	eng
Schlagworte:	4-(2,6-dichlorobenzyloxy)phenyl thiazole derivatives Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Anti-tubercular activity Antibacterial activity Antitubercular Agents - chemical synthesis Antitubercular Agents - chemistry Antitubercular Agents - pharmacology Bacteria - drug effects Bacterial Infections - drug therapy Biological and medical sciences Humans Imidazoles - chemical synthesis Imidazoles - chemistry Imidazoles - pharmacology Medical sciences Microbial Sensitivity Tests Miscellaneous Mycobacterium tuberculosis - drug effects Oxazoles - chemical synthesis Oxazoles - chemistry Oxazoles - pharmacology Pharmacology. Drug treatments Thiazoles - chemical synthesis Thiazoles - chemistry Thiazoles - pharmacology Tuberculosis - drug therapy
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