Fyn is not essential for Bcr-Abl-induced leukemogenesis in mouse bone marrow transplantation models

The Bcr-Abl oncogene causes human Philadelphia chromosome-positive (Ph + ) leukemias, including B-cell acute lymphoblastic leukemia (B-ALL) and chronic myeloid leukemia (CML) with chronic phase (CML-CP) to blast crisis (CML-BC). Previous studies have demonstrated that Src family kinases are required...

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Veröffentlicht in:	International journal of hematology 2012-02, Vol.95 (2), p.167-175
Hauptverfasser:	Doki, Noriko, Kitaura, Jiro, Uchida, Tomoyuki, Inoue, Daichi, Kagiyama, Yuki, Togami, Katsuhiro, Isobe, Masamichi, Ito, Shinichi, Maehara, Akie, Izawa, Kumi, Kato, Naoko, Oki, Toshihiko, Harada, Yuka, Nakahara, Fumio, Harada, Hironori, Kitamura, Toshio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Basic Helix-Loop-Helix Transcription Factors - genetics Biological and medical sciences Bone Marrow Transplantation Chromosome aberrations Disease Models, Animal Fusion Proteins, bcr-abl - genetics Gene Expression Regulation, Leukemic - physiology Hematologic and hematopoietic diseases Hematology Hematopoietic Stem Cells - physiology Homeodomain Proteins - genetics Humans Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics Leukemia, Myelogenous, Chronic, BCR-ABL Positive - physiopathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphoma, B-Cell - genetics Lymphoma, B-Cell - physiopathology Lymphoma, T-Cell - genetics Lymphoma, T-Cell - physiopathology Medical genetics Medical sciences Medicine Medicine & Public Health Mice Mice, Inbred C57BL Mice, Mutant Strains Myelodysplastic Syndromes - genetics Myelodysplastic Syndromes - physiopathology Oncology Original Article Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor Cell Lymphoblastic Leukemia-Lymphoma - physiopathology Proto-Oncogene Proteins c-fyn - genetics Proto-Oncogene Proteins c-fyn - physiology Transcription Factor HES-1
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