Morphological features of mutant rat, IS-Tlk/Kyo, fetuses with caudal vertebral anomalies
ABSTRACT IS‐Tlk/Kyo, a rat mutant strain derived from IS/Kyo strain, exhibits a kinked and/or short tail, in addition to a congenital anomaly of the lumbar vertebrae that is a hallmark of IS/Kyo rats. Homozygotes (Tlk/Tlk) of Tlk dominant gene are known to die during embryonic development. The prese...
Gespeichert in:
| Veröffentlicht in: | Congenital anomalies 2012-03, Vol.52 (1), p.42-47 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 47 |
|---|---|
| container_issue | 1 |
| container_start_page | 42 |
| container_title | Congenital anomalies |
| container_volume | 52 |
| creator | Takano, Masao Katsumata, Yoshihiro Ogawa, Junko Ebata, Tomonori Urasoko, Yoshinaka Asano, Yuzo Serikawa, Tadao Kuramoto, Takashi |
| description | ABSTRACT
IS‐Tlk/Kyo, a rat mutant strain derived from IS/Kyo strain, exhibits a kinked and/or short tail, in addition to a congenital anomaly of the lumbar vertebrae that is a hallmark of IS/Kyo rats. Homozygotes (Tlk/Tlk) of Tlk dominant gene are known to die during embryonic development. The present report deals with the morphological features of heterozygous IS‐Tlk/Kyo rat fetuses in comparison with those of IS/Kyo rat fetuses. One of the morphological features was a high incidence of tail vertebral anomalies in IS‐Tlk rats (81.6% versus 0% in IS/Kyo rats). Significantly low values in number of live fetuses and ossified 5th sternebra and sacral and caudal vertebrae were observed in IS‐Tlk/Kyo rats compared with those in IS/Kyo rats as well as a low incidence of fetuses with ventral septal defects in IS‐Tlk/Kyo (0% versus 54.4% in IS rats). These results suggest that the Tlk gene may be involved in the formation of the vertebral centra and the ventral septum when it expresses on the genetic background of the IS rat. |
| doi_str_mv | 10.1111/j.1741-4520.2011.00348.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_922759328</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>922759328</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4798-293dc0518a98e25d13fc18ed55fbb0d0abd4e5a762e1bd0ebac7b6bf21763d2a3</originalsourceid><addsrcrecordid>eNqNkF1P2zAUQK0JNDrYX5jythcS_BHHibQXVLZSrYDEx6Y9WXZ8M1KSurMd2v573BX6jF98JZ9zLR2EEoIzEs_ZPCMiJ2nOKc4oJiTDmOVltv6ARvuHAzTCFclTxjE_Qp-8n2NMi0Lgj-iI0oiLko7Qnyvrlo-2s3_bWnVJAyoMDnxim6QfglqExKlwmkzv0vvu6eznxp5GJgw-Iqs2PCa1Gkz0nsEF0C5OamF71bXgT9BhozoPn1_vY_Tw4_v9-DKd3Uym4_NZWueiKlNaMVNjTkpVlUC5IaypSQmG80ZrbLDSJgeuREGBaINBq1roQjeUiIIZqtgx-rrbu3T23wA-yL71NXSdWoAdvKwoFbxitIxkuSNrZ7130Mila3vlNpJgue0q53KbT27zyW1X-b-rXEf1y-sng-7B7MW3kBH4tgNWbQebdy-W48l5HKKe7vTWB1jvdeWeZCGY4PL39UT-ur2-mJDLQo7ZCwsPlis</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>922759328</pqid></control><display><type>article</type><title>Morphological features of mutant rat, IS-Tlk/Kyo, fetuses with caudal vertebral anomalies</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Takano, Masao ; Katsumata, Yoshihiro ; Ogawa, Junko ; Ebata, Tomonori ; Urasoko, Yoshinaka ; Asano, Yuzo ; Serikawa, Tadao ; Kuramoto, Takashi</creator><creatorcontrib>Takano, Masao ; Katsumata, Yoshihiro ; Ogawa, Junko ; Ebata, Tomonori ; Urasoko, Yoshinaka ; Asano, Yuzo ; Serikawa, Tadao ; Kuramoto, Takashi</creatorcontrib><description>ABSTRACT
IS‐Tlk/Kyo, a rat mutant strain derived from IS/Kyo strain, exhibits a kinked and/or short tail, in addition to a congenital anomaly of the lumbar vertebrae that is a hallmark of IS/Kyo rats. Homozygotes (Tlk/Tlk) of Tlk dominant gene are known to die during embryonic development. The present report deals with the morphological features of heterozygous IS‐Tlk/Kyo rat fetuses in comparison with those of IS/Kyo rat fetuses. One of the morphological features was a high incidence of tail vertebral anomalies in IS‐Tlk rats (81.6% versus 0% in IS/Kyo rats). Significantly low values in number of live fetuses and ossified 5th sternebra and sacral and caudal vertebrae were observed in IS‐Tlk/Kyo rats compared with those in IS/Kyo rats as well as a low incidence of fetuses with ventral septal defects in IS‐Tlk/Kyo (0% versus 54.4% in IS rats). These results suggest that the Tlk gene may be involved in the formation of the vertebral centra and the ventral septum when it expresses on the genetic background of the IS rat.</description><identifier>ISSN: 0914-3505</identifier><identifier>EISSN: 1741-4520</identifier><identifier>DOI: 10.1111/j.1741-4520.2011.00348.x</identifier><identifier>PMID: 22348782</identifier><language>eng</language><publisher>Melbourne, Australia: Blackwell Publishing Asia</publisher><subject>Animals ; Body Weight ; Crosses, Genetic ; Feeding Behavior ; Female ; Genes, Dominant ; Heterozygote ; Homozygote ; IS rat ; lumbar vertebral anomaly ; Male ; Models, Genetic ; Mutation ; Rats ; Rats, Mutant Strains ; Spine - abnormalities ; Time Factors ; Tlk gene ; ventral septal defect</subject><ispartof>Congenital anomalies, 2012-03, Vol.52 (1), p.42-47</ispartof><rights>2011 The Authors. Congenital Anomalies © 2011 Japanese Teratology Society</rights><rights>2011 The Authors. Congenital Anomalies © 2011 Japanese Teratology Society.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4798-293dc0518a98e25d13fc18ed55fbb0d0abd4e5a762e1bd0ebac7b6bf21763d2a3</citedby><cites>FETCH-LOGICAL-c4798-293dc0518a98e25d13fc18ed55fbb0d0abd4e5a762e1bd0ebac7b6bf21763d2a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1741-4520.2011.00348.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1741-4520.2011.00348.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22348782$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Takano, Masao</creatorcontrib><creatorcontrib>Katsumata, Yoshihiro</creatorcontrib><creatorcontrib>Ogawa, Junko</creatorcontrib><creatorcontrib>Ebata, Tomonori</creatorcontrib><creatorcontrib>Urasoko, Yoshinaka</creatorcontrib><creatorcontrib>Asano, Yuzo</creatorcontrib><creatorcontrib>Serikawa, Tadao</creatorcontrib><creatorcontrib>Kuramoto, Takashi</creatorcontrib><title>Morphological features of mutant rat, IS-Tlk/Kyo, fetuses with caudal vertebral anomalies</title><title>Congenital anomalies</title><addtitle>Congenit Anom (Kyoto)</addtitle><description>ABSTRACT
IS‐Tlk/Kyo, a rat mutant strain derived from IS/Kyo strain, exhibits a kinked and/or short tail, in addition to a congenital anomaly of the lumbar vertebrae that is a hallmark of IS/Kyo rats. Homozygotes (Tlk/Tlk) of Tlk dominant gene are known to die during embryonic development. The present report deals with the morphological features of heterozygous IS‐Tlk/Kyo rat fetuses in comparison with those of IS/Kyo rat fetuses. One of the morphological features was a high incidence of tail vertebral anomalies in IS‐Tlk rats (81.6% versus 0% in IS/Kyo rats). Significantly low values in number of live fetuses and ossified 5th sternebra and sacral and caudal vertebrae were observed in IS‐Tlk/Kyo rats compared with those in IS/Kyo rats as well as a low incidence of fetuses with ventral septal defects in IS‐Tlk/Kyo (0% versus 54.4% in IS rats). These results suggest that the Tlk gene may be involved in the formation of the vertebral centra and the ventral septum when it expresses on the genetic background of the IS rat.</description><subject>Animals</subject><subject>Body Weight</subject><subject>Crosses, Genetic</subject><subject>Feeding Behavior</subject><subject>Female</subject><subject>Genes, Dominant</subject><subject>Heterozygote</subject><subject>Homozygote</subject><subject>IS rat</subject><subject>lumbar vertebral anomaly</subject><subject>Male</subject><subject>Models, Genetic</subject><subject>Mutation</subject><subject>Rats</subject><subject>Rats, Mutant Strains</subject><subject>Spine - abnormalities</subject><subject>Time Factors</subject><subject>Tlk gene</subject><subject>ventral septal defect</subject><issn>0914-3505</issn><issn>1741-4520</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkF1P2zAUQK0JNDrYX5jythcS_BHHibQXVLZSrYDEx6Y9WXZ8M1KSurMd2v573BX6jF98JZ9zLR2EEoIzEs_ZPCMiJ2nOKc4oJiTDmOVltv6ARvuHAzTCFclTxjE_Qp-8n2NMi0Lgj-iI0oiLko7Qnyvrlo-2s3_bWnVJAyoMDnxim6QfglqExKlwmkzv0vvu6eznxp5GJgw-Iqs2PCa1Gkz0nsEF0C5OamF71bXgT9BhozoPn1_vY_Tw4_v9-DKd3Uym4_NZWueiKlNaMVNjTkpVlUC5IaypSQmG80ZrbLDSJgeuREGBaINBq1roQjeUiIIZqtgx-rrbu3T23wA-yL71NXSdWoAdvKwoFbxitIxkuSNrZ7130Mila3vlNpJgue0q53KbT27zyW1X-b-rXEf1y-sng-7B7MW3kBH4tgNWbQebdy-W48l5HKKe7vTWB1jvdeWeZCGY4PL39UT-ur2-mJDLQo7ZCwsPlis</recordid><startdate>201203</startdate><enddate>201203</enddate><creator>Takano, Masao</creator><creator>Katsumata, Yoshihiro</creator><creator>Ogawa, Junko</creator><creator>Ebata, Tomonori</creator><creator>Urasoko, Yoshinaka</creator><creator>Asano, Yuzo</creator><creator>Serikawa, Tadao</creator><creator>Kuramoto, Takashi</creator><general>Blackwell Publishing Asia</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201203</creationdate><title>Morphological features of mutant rat, IS-Tlk/Kyo, fetuses with caudal vertebral anomalies</title><author>Takano, Masao ; Katsumata, Yoshihiro ; Ogawa, Junko ; Ebata, Tomonori ; Urasoko, Yoshinaka ; Asano, Yuzo ; Serikawa, Tadao ; Kuramoto, Takashi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4798-293dc0518a98e25d13fc18ed55fbb0d0abd4e5a762e1bd0ebac7b6bf21763d2a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>Body Weight</topic><topic>Crosses, Genetic</topic><topic>Feeding Behavior</topic><topic>Female</topic><topic>Genes, Dominant</topic><topic>Heterozygote</topic><topic>Homozygote</topic><topic>IS rat</topic><topic>lumbar vertebral anomaly</topic><topic>Male</topic><topic>Models, Genetic</topic><topic>Mutation</topic><topic>Rats</topic><topic>Rats, Mutant Strains</topic><topic>Spine - abnormalities</topic><topic>Time Factors</topic><topic>Tlk gene</topic><topic>ventral septal defect</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Takano, Masao</creatorcontrib><creatorcontrib>Katsumata, Yoshihiro</creatorcontrib><creatorcontrib>Ogawa, Junko</creatorcontrib><creatorcontrib>Ebata, Tomonori</creatorcontrib><creatorcontrib>Urasoko, Yoshinaka</creatorcontrib><creatorcontrib>Asano, Yuzo</creatorcontrib><creatorcontrib>Serikawa, Tadao</creatorcontrib><creatorcontrib>Kuramoto, Takashi</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Congenital anomalies</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Takano, Masao</au><au>Katsumata, Yoshihiro</au><au>Ogawa, Junko</au><au>Ebata, Tomonori</au><au>Urasoko, Yoshinaka</au><au>Asano, Yuzo</au><au>Serikawa, Tadao</au><au>Kuramoto, Takashi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Morphological features of mutant rat, IS-Tlk/Kyo, fetuses with caudal vertebral anomalies</atitle><jtitle>Congenital anomalies</jtitle><addtitle>Congenit Anom (Kyoto)</addtitle><date>2012-03</date><risdate>2012</risdate><volume>52</volume><issue>1</issue><spage>42</spage><epage>47</epage><pages>42-47</pages><issn>0914-3505</issn><eissn>1741-4520</eissn><abstract>ABSTRACT
IS‐Tlk/Kyo, a rat mutant strain derived from IS/Kyo strain, exhibits a kinked and/or short tail, in addition to a congenital anomaly of the lumbar vertebrae that is a hallmark of IS/Kyo rats. Homozygotes (Tlk/Tlk) of Tlk dominant gene are known to die during embryonic development. The present report deals with the morphological features of heterozygous IS‐Tlk/Kyo rat fetuses in comparison with those of IS/Kyo rat fetuses. One of the morphological features was a high incidence of tail vertebral anomalies in IS‐Tlk rats (81.6% versus 0% in IS/Kyo rats). Significantly low values in number of live fetuses and ossified 5th sternebra and sacral and caudal vertebrae were observed in IS‐Tlk/Kyo rats compared with those in IS/Kyo rats as well as a low incidence of fetuses with ventral septal defects in IS‐Tlk/Kyo (0% versus 54.4% in IS rats). These results suggest that the Tlk gene may be involved in the formation of the vertebral centra and the ventral septum when it expresses on the genetic background of the IS rat.</abstract><cop>Melbourne, Australia</cop><pub>Blackwell Publishing Asia</pub><pmid>22348782</pmid><doi>10.1111/j.1741-4520.2011.00348.x</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0914-3505 |
| ispartof | Congenital anomalies, 2012-03, Vol.52 (1), p.42-47 |
| issn | 0914-3505 1741-4520 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_922759328 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals Body Weight Crosses, Genetic Feeding Behavior Female Genes, Dominant Heterozygote Homozygote IS rat lumbar vertebral anomaly Male Models, Genetic Mutation Rats Rats, Mutant Strains Spine - abnormalities Time Factors Tlk gene ventral septal defect |
| title | Morphological features of mutant rat, IS-Tlk/Kyo, fetuses with caudal vertebral anomalies |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-26T16%3A19%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Morphological%20features%20of%20mutant%20rat,%20IS-Tlk/Kyo,%20fetuses%20with%20caudal%20vertebral%20anomalies&rft.jtitle=Congenital%20anomalies&rft.au=Takano,%20Masao&rft.date=2012-03&rft.volume=52&rft.issue=1&rft.spage=42&rft.epage=47&rft.pages=42-47&rft.issn=0914-3505&rft.eissn=1741-4520&rft_id=info:doi/10.1111/j.1741-4520.2011.00348.x&rft_dat=%3Cproquest_cross%3E922759328%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=922759328&rft_id=info:pmid/22348782&rfr_iscdi=true |