In-vivo and ex-vivo studies on region-specific remodeling of large elastic arteries due to simulated weightlessness and its prevention by gravity-based countermeasure
The present study was designed to test the hypothesis that a medium-term simulated microgravity can induce region-specific remodeling in large elastic arteries with their innermost smooth muscle (SM) layers being most profoundly affected. The second purpose was to examine whether these changes can b...
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| Veröffentlicht in: | Sheng li hsüeh pao 2012-02, Vol.64 (1), p.14-26 |
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| container_title | Sheng li hsüeh pao |
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| creator | Gao, Fang Cheng, Jiu-Hua Xue, Jun-Hui Bai, Yun-Gang Chen, Ming-Sheng Huang, Wei-Quan Huang, Jing Wu, Sheng-Xi Han, Hai-Chao Zhang, Li-Fan |
| description | The present study was designed to test the hypothesis that a medium-term simulated microgravity can induce region-specific remodeling in large elastic arteries with their innermost smooth muscle (SM) layers being most profoundly affected. The second purpose was to examine whether these changes can be prevented by a simulated intermittent artificial gravity (IAG). The third purpose was to elucidate whether vascular local renin-angiotensin system (L-RAS) plays an important role in the regional vascular remodeling and its prevention by the gravity-based countermeasure. This study consisted of two interconnected series of in-vivo and ex-vivo experiments. In the in-vivo experiments, the tail-suspended, hindlimb unloaded rat model was used to simulate microgravity-induced cardiovascular deconditioning for 28 days (SUS group); and during the simulation period, another group was subjected to daily 1-hour dorso-ventral (-G(x)) gravitation provided by restoring to normal standing posture (S + D group). The activity of |
| format | Article |
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The second purpose was to examine whether these changes can be prevented by a simulated intermittent artificial gravity (IAG). The third purpose was to elucidate whether vascular local renin-angiotensin system (L-RAS) plays an important role in the regional vascular remodeling and its prevention by the gravity-based countermeasure. This study consisted of two interconnected series of in-vivo and ex-vivo experiments. In the in-vivo experiments, the tail-suspended, hindlimb unloaded rat model was used to simulate microgravity-induced cardiovascular deconditioning for 28 days (SUS group); and during the simulation period, another group was subjected to daily 1-hour dorso-ventral (-G(x)) gravitation provided by restoring to normal standing posture (S + D group). The activity of</description><identifier>ISSN: 0371-0874</identifier><identifier>PMID: 22348956</identifier><language>chi</language><publisher>China</publisher><subject>Angiotensinogen - genetics ; Angiotensinogen - metabolism ; Animals ; Aorta, Abdominal - pathology ; Aorta, Abdominal - physiopathology ; Carotid Artery, Common - pathology ; Carotid Artery, Common - physiopathology ; Hindlimb Suspension ; Male ; Muscle, Smooth, Vascular - metabolism ; Muscle, Smooth, Vascular - pathology ; Rats ; Rats, Sprague-Dawley ; Receptor, Angiotensin, Type 1 - genetics ; Receptor, Angiotensin, Type 1 - metabolism ; Renin-Angiotensin System - physiology ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; Weightlessness Simulation</subject><ispartof>Sheng li hsüeh pao, 2012-02, Vol.64 (1), p.14-26</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22348956$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gao, Fang</creatorcontrib><creatorcontrib>Cheng, Jiu-Hua</creatorcontrib><creatorcontrib>Xue, Jun-Hui</creatorcontrib><creatorcontrib>Bai, Yun-Gang</creatorcontrib><creatorcontrib>Chen, Ming-Sheng</creatorcontrib><creatorcontrib>Huang, Wei-Quan</creatorcontrib><creatorcontrib>Huang, Jing</creatorcontrib><creatorcontrib>Wu, Sheng-Xi</creatorcontrib><creatorcontrib>Han, Hai-Chao</creatorcontrib><creatorcontrib>Zhang, Li-Fan</creatorcontrib><title>In-vivo and ex-vivo studies on region-specific remodeling of large elastic arteries due to simulated weightlessness and its prevention by gravity-based countermeasure</title><title>Sheng li hsüeh pao</title><addtitle>Sheng Li Xue Bao</addtitle><description>The present study was designed to test the hypothesis that a medium-term simulated microgravity can induce region-specific remodeling in large elastic arteries with their innermost smooth muscle (SM) layers being most profoundly affected. The second purpose was to examine whether these changes can be prevented by a simulated intermittent artificial gravity (IAG). The third purpose was to elucidate whether vascular local renin-angiotensin system (L-RAS) plays an important role in the regional vascular remodeling and its prevention by the gravity-based countermeasure. This study consisted of two interconnected series of in-vivo and ex-vivo experiments. In the in-vivo experiments, the tail-suspended, hindlimb unloaded rat model was used to simulate microgravity-induced cardiovascular deconditioning for 28 days (SUS group); and during the simulation period, another group was subjected to daily 1-hour dorso-ventral (-G(x)) gravitation provided by restoring to normal standing posture (S + D group). The activity of</description><subject>Angiotensinogen - genetics</subject><subject>Angiotensinogen - metabolism</subject><subject>Animals</subject><subject>Aorta, Abdominal - pathology</subject><subject>Aorta, Abdominal - physiopathology</subject><subject>Carotid Artery, Common - pathology</subject><subject>Carotid Artery, Common - physiopathology</subject><subject>Hindlimb Suspension</subject><subject>Male</subject><subject>Muscle, Smooth, Vascular - metabolism</subject><subject>Muscle, Smooth, Vascular - pathology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptor, Angiotensin, Type 1 - genetics</subject><subject>Receptor, Angiotensin, Type 1 - metabolism</subject><subject>Renin-Angiotensin System - physiology</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>Weightlessness Simulation</subject><issn>0371-0874</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kMtOw0AMRbMA0ar0F9DsWEXKY5KZLFHFoxISG1hHztgJIyWTMI9Cf4jvZKBlYdlX9j1X8kWyzkqRp5kUfJVsndNdVuWl4FyKq2RVFCWXTVWvk--9SQ_6MDMwyOjrNDsfUJNjs2GWBj2b1C2kdK9V1NOMNGozsLlnI9iBGI3gfNyB9WR_fRiI-YjRUxjBE7JP0sO7H8k5E-svS3vHFksHMj4GsO7IBgsH7Y9pBy5a1BxMxE0ELli6Ti57GB1tz32TvD3cv-6e0ueXx_3u7jld8qLyaa-QyqzMFAJmXc4BC6rzmitErJtMSiRqKoWCg-w4B-ACMyGFxKaXQpXlJrk9cRc7fwRyvp20UzSOYGgOrm2KQlSiihmb5OZ8GbqJsF2snsAe2__Xlj8wvHrk</recordid><startdate>20120225</startdate><enddate>20120225</enddate><creator>Gao, Fang</creator><creator>Cheng, Jiu-Hua</creator><creator>Xue, Jun-Hui</creator><creator>Bai, Yun-Gang</creator><creator>Chen, Ming-Sheng</creator><creator>Huang, Wei-Quan</creator><creator>Huang, Jing</creator><creator>Wu, Sheng-Xi</creator><creator>Han, Hai-Chao</creator><creator>Zhang, Li-Fan</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20120225</creationdate><title>In-vivo and ex-vivo studies on region-specific remodeling of large elastic arteries due to simulated weightlessness and its prevention by gravity-based countermeasure</title><author>Gao, Fang ; Cheng, Jiu-Hua ; Xue, Jun-Hui ; Bai, Yun-Gang ; Chen, Ming-Sheng ; Huang, Wei-Quan ; Huang, Jing ; Wu, Sheng-Xi ; Han, Hai-Chao ; Zhang, Li-Fan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p125t-fcde3030cdad0b14ad2e6164cddd69088dee95cd74a8b44aa47d07878d9f87c33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>chi</language><creationdate>2012</creationdate><topic>Angiotensinogen - genetics</topic><topic>Angiotensinogen - metabolism</topic><topic>Animals</topic><topic>Aorta, Abdominal - pathology</topic><topic>Aorta, Abdominal - physiopathology</topic><topic>Carotid Artery, Common - pathology</topic><topic>Carotid Artery, Common - physiopathology</topic><topic>Hindlimb Suspension</topic><topic>Male</topic><topic>Muscle, Smooth, Vascular - metabolism</topic><topic>Muscle, Smooth, Vascular - pathology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptor, Angiotensin, Type 1 - genetics</topic><topic>Receptor, Angiotensin, Type 1 - metabolism</topic><topic>Renin-Angiotensin System - physiology</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>Weightlessness Simulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gao, Fang</creatorcontrib><creatorcontrib>Cheng, Jiu-Hua</creatorcontrib><creatorcontrib>Xue, Jun-Hui</creatorcontrib><creatorcontrib>Bai, Yun-Gang</creatorcontrib><creatorcontrib>Chen, Ming-Sheng</creatorcontrib><creatorcontrib>Huang, Wei-Quan</creatorcontrib><creatorcontrib>Huang, Jing</creatorcontrib><creatorcontrib>Wu, Sheng-Xi</creatorcontrib><creatorcontrib>Han, Hai-Chao</creatorcontrib><creatorcontrib>Zhang, Li-Fan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Sheng li hsüeh pao</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gao, Fang</au><au>Cheng, Jiu-Hua</au><au>Xue, Jun-Hui</au><au>Bai, Yun-Gang</au><au>Chen, Ming-Sheng</au><au>Huang, Wei-Quan</au><au>Huang, Jing</au><au>Wu, Sheng-Xi</au><au>Han, Hai-Chao</au><au>Zhang, Li-Fan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In-vivo and ex-vivo studies on region-specific remodeling of large elastic arteries due to simulated weightlessness and its prevention by gravity-based countermeasure</atitle><jtitle>Sheng li hsüeh pao</jtitle><addtitle>Sheng Li Xue Bao</addtitle><date>2012-02-25</date><risdate>2012</risdate><volume>64</volume><issue>1</issue><spage>14</spage><epage>26</epage><pages>14-26</pages><issn>0371-0874</issn><abstract>The present study was designed to test the hypothesis that a medium-term simulated microgravity can induce region-specific remodeling in large elastic arteries with their innermost smooth muscle (SM) layers being most profoundly affected. The second purpose was to examine whether these changes can be prevented by a simulated intermittent artificial gravity (IAG). The third purpose was to elucidate whether vascular local renin-angiotensin system (L-RAS) plays an important role in the regional vascular remodeling and its prevention by the gravity-based countermeasure. This study consisted of two interconnected series of in-vivo and ex-vivo experiments. In the in-vivo experiments, the tail-suspended, hindlimb unloaded rat model was used to simulate microgravity-induced cardiovascular deconditioning for 28 days (SUS group); and during the simulation period, another group was subjected to daily 1-hour dorso-ventral (-G(x)) gravitation provided by restoring to normal standing posture (S + D group). The activity of</abstract><cop>China</cop><pmid>22348956</pmid><tpages>13</tpages></addata></record> |
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| ispartof | Sheng li hsüeh pao, 2012-02, Vol.64 (1), p.14-26 |
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| language | chi |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Angiotensinogen - genetics Angiotensinogen - metabolism Animals Aorta, Abdominal - pathology Aorta, Abdominal - physiopathology Carotid Artery, Common - pathology Carotid Artery, Common - physiopathology Hindlimb Suspension Male Muscle, Smooth, Vascular - metabolism Muscle, Smooth, Vascular - pathology Rats Rats, Sprague-Dawley Receptor, Angiotensin, Type 1 - genetics Receptor, Angiotensin, Type 1 - metabolism Renin-Angiotensin System - physiology RNA, Messenger - genetics RNA, Messenger - metabolism Weightlessness Simulation |
| title | In-vivo and ex-vivo studies on region-specific remodeling of large elastic arteries due to simulated weightlessness and its prevention by gravity-based countermeasure |
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