Immuno- and Constitutive Proteasome Crystal Structures Reveal Differences in Substrate and Inhibitor Specificity

Constitutive proteasomes and immunoproteasomes shape the peptide repertoire presented by major histocompatibility complex class I (MHC-I) molecules by harboring different sets of catalytically active subunits. Here, we present the crystal structures of constitutive proteasomes and immunoproteasomes...

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Veröffentlicht in:	Cell 2012-02, Vol.148 (4), p.727-738
Hauptverfasser:	Huber, Eva M., Basler, Michael, Schwab, Ricarda, Heinemeyer, Wolfgang, Kirk, Christopher J., Groettrup, Marcus, Groll, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	active sites Amino Acid Sequence Animals Antigen Presentation crystal structure Crystallography, X-Ray cytokines Histocompatibility Antigens Class I - metabolism Major Histocompatibility Complex Mice Models, Molecular Molecular Sequence Data Oligopeptides - pharmacology proteasome endopeptidase complex Proteasome Endopeptidase Complex - chemistry Proteasome Endopeptidase Complex - metabolism Proteasome Inhibitors Saccharomyces cerevisiae - chemistry Sequence Alignment X-radiation yeasts
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