Bv8/PK2 and prokineticin receptors: a druggable pronociceptive system

Highlights ► Bv8 is a secreted protein that regulates diverse biological processes including pain. ► It belongs to a new family of chemokines strongly upregulated by inflammation. ► Bv8 is a main pronociceptive mediator in inflamed tissues. ► Blocking the Bv8 receptors (PKR1 and PKR2) ameliorates pa...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Current opinion in pharmacology 2012-02, Vol.12 (1), p.62-66
Hauptverfasser:	Negri, Lucia, Lattanzi, Roberta
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics - pharmacology Animals Gastrointestinal Hormones - metabolism Humans Internal Medicine Medical Education Neuropeptides - metabolism Pain - drug therapy Pain - metabolism Receptors, G-Protein-Coupled - metabolism Receptors, Peptide - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!