Adenovirus-Mediated Gene Transfer of TGF-β1 to the Renal Glomeruli Leads to Proteinuria

The mechanism of proteinuria in many common kidney diseases involves glomerular hemodynamic effects and local expression of angiogenic, fibrogenic, and vasoactive factors. Transforming growth factor (TGF)-β has been associated with many diseases involving proteinuria and renal fibrosis. TGF-β has be...

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Veröffentlicht in:	The American journal of pathology 2012-03, Vol.180 (3), p.940-951
Hauptverfasser:	Ghayur, Ayesha, Liu, Limin, Kolb, Martin, Chawla, Arun, Lambe, Shahid, Kapoor, Anil, Margetts, Peter J
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Adenoviridae Angiopoietin-1 - metabolism Angiopoietin-2 - metabolism Animals Biological and medical sciences Cell Dedifferentiation Cells, Cultured Down-Regulation Female Gene Transfer Techniques Genetic Vectors Glomerular Filtration Barrier - metabolism Investigative techniques, diagnostic techniques (general aspects) Kidney Glomerulus - metabolism Kidney Glomerulus - pathology Medical sciences Membrane Proteins - metabolism Membrane Proteins - urine Nephrology. Urinary tract diseases Pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Podocytes - metabolism Podocytes - pathology Proteinuria - etiology Proteinuria - pathology Rats Rats, Sprague-Dawley Snail Family Transcription Factors Synaptophysin - metabolism Transcription Factors - metabolism Transforming Growth Factor beta1 - metabolism Transforming Growth Factor beta1 - physiology Urinary system involvement in other diseases. Miscellaneous Urinary tract. Prostate gland
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