Sialylation of epidermal growth factor receptor regulates receptor activity and chemosensitivity to gefitinib in colon cancer cells

β-Galactoside α2,6-sialyltransferase (ST6Gal-I) has been shown to catalyze α2,6 sialylation of N-glycan, an action that is highly correlated with colon cancer progression and metastasis. We have recently demonstrated that ST6Gal-I-induced α2,6 sialylation is critical for adhesion and migration of co...

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Veröffentlicht in:	Biochemical pharmacology 2012-04, Vol.83 (7), p.849-857
Hauptverfasser:	Park, Jung-Jin, Yi, Jae Youn, Jin, Yeung Bae, Lee, Yoon-Jin, Lee, Jae-Seon, Lee, Yun-Sil, Ko, Young-Gyu, Lee, Minyoung
Format:	Artikel
Sprache:	eng
Schlagworte:	adhesion Animals anticarcinogenic activity Antigens, CD - genetics Antigens, CD - metabolism Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Apoptosis - drug effects beta -Galactoside alpha -2,6-sialyltransferase carcinogenesis Cell Culture Techniques cell growth Cell migration Cell proliferation Cell Proliferation - drug effects Cell Survival - drug effects Chemoresistance Colon cancer Colonic Neoplasms - drug therapy Colonic Neoplasms - metabolism Colonic Neoplasms - pathology Colorectal carcinoma colorectal neoplasms Cytotoxicity Drug Resistance, Neoplasm EGFR enzyme substrates Enzymes Epidermal growth factor receptors Extracellular signal-regulated kinase Flow Cytometry Gefitinib HT29 Cells Humans Immunoblotting Immunoprecipitation In Situ Nick-End Labeling Malignancy Metastases metastasis Mice Mice, Nude mitogen-activated protein kinase mutants N-glycans Phosphorylation Quinazolines - pharmacology Quinazolines - therapeutic use radiation resistance Radioresistance Receptor, Epidermal Growth Factor - antagonists & inhibitors Receptor, Epidermal Growth Factor - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Small Interfering - pharmacology Sialic Acids - metabolism Sialylation Sialyltransferases - genetics Sialyltransferases - metabolism ST6Gal I Transfection Tumor cell lines Tumorigenesis Xenograft Model Antitumor Assays
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