Role of lipids in the interaction of antimicrobial peptides with membranes

Antimicrobial peptides (AMPs) take part in the immune system by mounting a first line of defense against pathogens. Recurrent structural and functional aspects are observed among peptides from different sources, particularly the net cationicity and amphipathicity. However, the membrane seems to be t...

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Veröffentlicht in:	Progress in lipid research 2012-04, Vol.51 (2), p.149-177
Hauptverfasser:	Teixeira, Vitor, Feio, Maria J., Bastos, Margarida
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Infective Agents - metabolism Anti-Infective Agents - pharmacology Anti-Infective Agents - therapeutic use Antimicrobial Cationic Peptides - metabolism Antimicrobial Cationic Peptides - pharmacology Antimicrobial Cationic Peptides - therapeutic use Antimicrobial peptide Bacterial Infections - drug therapy Cell death Cell Membrane - chemistry Cell Membrane - drug effects Cell Membrane - metabolism Cell Membrane Permeability Drug Resistance, Microbial Humans Hydrophobic and Hydrophilic Interactions Immunity Intracellular targets Mechanism of action Membrane permeabilization Membrane topology Peptide design Phospholipids Phospholipids - metabolism Protein Structure, Secondary Resistance Structure–activity relationship Target activity Therapeutic agents
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