Synthesis of Functionalized Indolizines via Copper-Catalyzed Annulation of 2-Alkylazaarenes with α,β-Unsaturated Carboxylic Acids

Synthesis of Functionalized Indolizines via Copper-Catalyzed Annulation of 2-Alkylazaarenes with α,β-Unsaturated Carboxylic Acids

A novel copper-catalyzed annulation of 2-alkylazaarenes with α,β-unsaturated carboxylic acids has been accomplished. This reaction featuring C–H olefination and decarboxylative amination processes provides a concise access to C-2 arylated indolizines from simple and readily available starting materi...

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Veröffentlicht in:Organic letters 2012-02, Vol.14 (4), p.957-959
Hauptverfasser: Yang, Yuzhu, Xie, Chunsong, Xie, Yongju, Zhang, Yuhong
Format: Artikel
Sprache:eng
Schlagworte:
Alkenes - chemistry
Aza Compounds - chemistry
Carboxylic Acids - chemistry
Catalysis
Copper - chemistry
Indolizines - chemical synthesis
Molecular Structure
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Zusammenfassung:A novel copper-catalyzed annulation of 2-alkylazaarenes with α,β-unsaturated carboxylic acids has been accomplished. This reaction featuring C–H olefination and decarboxylative amination processes provides a concise access to C-2 arylated indolizines from simple and readily available starting materials.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol300067h