Impact of Statin Therapy on Plaque Characteristics as Assessed by Serial OCT, Grayscale and Integrated Backscatter–IVUS
Objectives The purpose of this study was to evaluate the effect of statin treatment on coronary plaque composition and morphology by optical coherence tomography (OCT), grayscale and integrated backscatter (IB) intravascular ultrasound (IVUS) imaging. Background Although previous studies have demons...
Gespeichert in:
| Veröffentlicht in: | JACC. Cardiovascular imaging 2012-02, Vol.5 (2), p.169-177 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 177 |
|---|---|
| container_issue | 2 |
| container_start_page | 169 |
| container_title | JACC. Cardiovascular imaging |
| container_volume | 5 |
| creator | Hattori, Kousuke, MD Ozaki, Yukio, MD Ismail, Tevfik F., MBBS Okumura, Masanori, MD Naruse, Hiroyuki, MD Kan, Shino, MD Ishikawa, Makoto, MD Kawai, Tomoko, MD Ohta, Masaya, MD Kawai, Hideki, MD Hashimoto, Tousei, MD Takagi, Yasushi, MD Ishii, Junichi, MD Serruys, Patrick W., MD Narula, Jagat, MD |
| description | Objectives The purpose of this study was to evaluate the effect of statin treatment on coronary plaque composition and morphology by optical coherence tomography (OCT), grayscale and integrated backscatter (IB) intravascular ultrasound (IVUS) imaging. Background Although previous studies have demonstrated that statins substantially improve cardiac mortality, their precise effect on the lipid content and fibrous cap thickness of atherosclerotic coronary lesions is less clear. While IVUS lacks the spatial resolution to accurately assess fibrous cap thickness, OCT lacks the penetration of IVUS. We used a combination of OCT, grayscale and IB-IVUS to comprehensively assess the impact of pitavastatin on plaque characteristics. Methods Prospective serial OCT, grayscale and IB-IVUS of nontarget lesions was performed in 42 stable angina patients undergoing elective coronary intervention. Of these, 26 received 4 mg pitavastatin after the baseline study; 16 subjects who refused statin treatment were followed with dietary modification alone. Follow-up imaging was performed after a median interval of 9 months. Results Grayscale IVUS revealed that in the statin-treated patients, percent plaque volume index was significantly reduced over time (48.5 ± 10.4%, 42.0 ± 11.1%; p = 0.033), whereas no change was observed in the diet-only patients (48.7 ± 10.4%, 50.4 ± 11.8%; p = NS). IB-IVUS identified significant reductions in the percentage lipid volume index over time (34.9 ± 12.2%, 28.2 ± 7.5%; p = 0.020); no change was observed in the diet-treated group (31.0 ± 10.7%, 33.8 ± 12.4%; p = NS). While OCT demonstrated a significant increase in fibrous cap thickness (140 ± 42 μm, 189 ± 46 μm; p = 0.001), such changes were not observed in the diet-only group (140 ± 35 μm, 142 ± 36 μm; p = NS). Differences in the changes in the percentage lipid volume index (−6.8 ± 8.0% vs. 2.8 ± 9.9%, p = 0.031) and fibrous cap thickness (52 ± 32 μm vs. 2 ± 22 μm, p < 0.001) over time between the pitavastatin and diet groups were highly significant. Conclusions Statin treatment induces favorable plaque morphologic changes with an increase in fibrous cap thickness, and decreases in both percentage plaque and lipid volume indexes. |
| doi_str_mv | 10.1016/j.jcmg.2011.11.012 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_922499772</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S1936878X11008916</els_id><sourcerecordid>922499772</sourcerecordid><originalsourceid>FETCH-LOGICAL-c467t-f6f5f1152500c812ec8f3fba3d71907eb00ad09b080ca27ef8529edef47679d93</originalsourceid><addsrcrecordid>eNo9kc1q3DAUhUVpadK0L9BF0a6beHIl25K1KaRDmw4EUphJ6U7I8lVixz9TSRPwru_QN-yTVGaSwgEJ7rkHzncJec9gxYCJi27V2eFuxYGxVRIw_oKcskqKTJaKvUx_lYusktXPE_ImhA5AgCjka3LCeV5AxfNTMm-GvbGRTo5uo4ntSHf36M1-ptNIv_fm1wHp-t745EHfhtjaQE2glyFgUkPrmW7TwPT0Zr07p1fezMGaHqkZG7oZI955E5Pvs7EPaRBTyt_ffzY_brdvyStn-oDvnt4zcvv1y279Lbu-udqsL68zWwgZMydc6RgreQlgK8bRVi53tckbyRRIrAFMA6qGCqzhEl1VcoUNukIKqRqVn5GPx9y9n1KbEPXQBot9b0acDkErzgulpOTJyY9O66cQPDq99-1g_KwZ6IW47vRCXC_EdVIinpY-PMUf6gGb_yvPiJPh09GAqeRji17bvh3bBOkBZwzddPBj6q-ZDlyD3i5HW27GGEClmMj_AeLGlBc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>922499772</pqid></control><display><type>article</type><title>Impact of Statin Therapy on Plaque Characteristics as Assessed by Serial OCT, Grayscale and Integrated Backscatter–IVUS</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Hattori, Kousuke, MD ; Ozaki, Yukio, MD ; Ismail, Tevfik F., MBBS ; Okumura, Masanori, MD ; Naruse, Hiroyuki, MD ; Kan, Shino, MD ; Ishikawa, Makoto, MD ; Kawai, Tomoko, MD ; Ohta, Masaya, MD ; Kawai, Hideki, MD ; Hashimoto, Tousei, MD ; Takagi, Yasushi, MD ; Ishii, Junichi, MD ; Serruys, Patrick W., MD ; Narula, Jagat, MD</creator><creatorcontrib>Hattori, Kousuke, MD ; Ozaki, Yukio, MD ; Ismail, Tevfik F., MBBS ; Okumura, Masanori, MD ; Naruse, Hiroyuki, MD ; Kan, Shino, MD ; Ishikawa, Makoto, MD ; Kawai, Tomoko, MD ; Ohta, Masaya, MD ; Kawai, Hideki, MD ; Hashimoto, Tousei, MD ; Takagi, Yasushi, MD ; Ishii, Junichi, MD ; Serruys, Patrick W., MD ; Narula, Jagat, MD</creatorcontrib><description>Objectives The purpose of this study was to evaluate the effect of statin treatment on coronary plaque composition and morphology by optical coherence tomography (OCT), grayscale and integrated backscatter (IB) intravascular ultrasound (IVUS) imaging. Background Although previous studies have demonstrated that statins substantially improve cardiac mortality, their precise effect on the lipid content and fibrous cap thickness of atherosclerotic coronary lesions is less clear. While IVUS lacks the spatial resolution to accurately assess fibrous cap thickness, OCT lacks the penetration of IVUS. We used a combination of OCT, grayscale and IB-IVUS to comprehensively assess the impact of pitavastatin on plaque characteristics. Methods Prospective serial OCT, grayscale and IB-IVUS of nontarget lesions was performed in 42 stable angina patients undergoing elective coronary intervention. Of these, 26 received 4 mg pitavastatin after the baseline study; 16 subjects who refused statin treatment were followed with dietary modification alone. Follow-up imaging was performed after a median interval of 9 months. Results Grayscale IVUS revealed that in the statin-treated patients, percent plaque volume index was significantly reduced over time (48.5 ± 10.4%, 42.0 ± 11.1%; p = 0.033), whereas no change was observed in the diet-only patients (48.7 ± 10.4%, 50.4 ± 11.8%; p = NS). IB-IVUS identified significant reductions in the percentage lipid volume index over time (34.9 ± 12.2%, 28.2 ± 7.5%; p = 0.020); no change was observed in the diet-treated group (31.0 ± 10.7%, 33.8 ± 12.4%; p = NS). While OCT demonstrated a significant increase in fibrous cap thickness (140 ± 42 μm, 189 ± 46 μm; p = 0.001), such changes were not observed in the diet-only group (140 ± 35 μm, 142 ± 36 μm; p = NS). Differences in the changes in the percentage lipid volume index (−6.8 ± 8.0% vs. 2.8 ± 9.9%, p = 0.031) and fibrous cap thickness (52 ± 32 μm vs. 2 ± 22 μm, p < 0.001) over time between the pitavastatin and diet groups were highly significant. Conclusions Statin treatment induces favorable plaque morphologic changes with an increase in fibrous cap thickness, and decreases in both percentage plaque and lipid volume indexes.</description><identifier>ISSN: 1936-878X</identifier><identifier>EISSN: 1876-7591</identifier><identifier>DOI: 10.1016/j.jcmg.2011.11.012</identifier><identifier>PMID: 22340823</identifier><language>eng</language><publisher>United States</publisher><subject>Aged ; Cardiovascular ; Coronary Angiography ; Coronary Artery Disease - diagnostic imaging ; Coronary Artery Disease - drug therapy ; Coronary Artery Disease - pathology ; Coronary Vessels - diagnostic imaging ; Female ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use ; Male ; Plaque, Atherosclerotic - diagnostic imaging ; Plaque, Atherosclerotic - drug therapy ; Plaque, Atherosclerotic - pathology ; Quinolines - therapeutic use ; Tomography, Optical Coherence ; Ultrasonography, Interventional</subject><ispartof>JACC. Cardiovascular imaging, 2012-02, Vol.5 (2), p.169-177</ispartof><rights>American College of Cardiology Foundation</rights><rights>Copyright © 2012 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c467t-f6f5f1152500c812ec8f3fba3d71907eb00ad09b080ca27ef8529edef47679d93</citedby><cites>FETCH-LOGICAL-c467t-f6f5f1152500c812ec8f3fba3d71907eb00ad09b080ca27ef8529edef47679d93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22340823$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hattori, Kousuke, MD</creatorcontrib><creatorcontrib>Ozaki, Yukio, MD</creatorcontrib><creatorcontrib>Ismail, Tevfik F., MBBS</creatorcontrib><creatorcontrib>Okumura, Masanori, MD</creatorcontrib><creatorcontrib>Naruse, Hiroyuki, MD</creatorcontrib><creatorcontrib>Kan, Shino, MD</creatorcontrib><creatorcontrib>Ishikawa, Makoto, MD</creatorcontrib><creatorcontrib>Kawai, Tomoko, MD</creatorcontrib><creatorcontrib>Ohta, Masaya, MD</creatorcontrib><creatorcontrib>Kawai, Hideki, MD</creatorcontrib><creatorcontrib>Hashimoto, Tousei, MD</creatorcontrib><creatorcontrib>Takagi, Yasushi, MD</creatorcontrib><creatorcontrib>Ishii, Junichi, MD</creatorcontrib><creatorcontrib>Serruys, Patrick W., MD</creatorcontrib><creatorcontrib>Narula, Jagat, MD</creatorcontrib><title>Impact of Statin Therapy on Plaque Characteristics as Assessed by Serial OCT, Grayscale and Integrated Backscatter–IVUS</title><title>JACC. Cardiovascular imaging</title><addtitle>JACC Cardiovasc Imaging</addtitle><description>Objectives The purpose of this study was to evaluate the effect of statin treatment on coronary plaque composition and morphology by optical coherence tomography (OCT), grayscale and integrated backscatter (IB) intravascular ultrasound (IVUS) imaging. Background Although previous studies have demonstrated that statins substantially improve cardiac mortality, their precise effect on the lipid content and fibrous cap thickness of atherosclerotic coronary lesions is less clear. While IVUS lacks the spatial resolution to accurately assess fibrous cap thickness, OCT lacks the penetration of IVUS. We used a combination of OCT, grayscale and IB-IVUS to comprehensively assess the impact of pitavastatin on plaque characteristics. Methods Prospective serial OCT, grayscale and IB-IVUS of nontarget lesions was performed in 42 stable angina patients undergoing elective coronary intervention. Of these, 26 received 4 mg pitavastatin after the baseline study; 16 subjects who refused statin treatment were followed with dietary modification alone. Follow-up imaging was performed after a median interval of 9 months. Results Grayscale IVUS revealed that in the statin-treated patients, percent plaque volume index was significantly reduced over time (48.5 ± 10.4%, 42.0 ± 11.1%; p = 0.033), whereas no change was observed in the diet-only patients (48.7 ± 10.4%, 50.4 ± 11.8%; p = NS). IB-IVUS identified significant reductions in the percentage lipid volume index over time (34.9 ± 12.2%, 28.2 ± 7.5%; p = 0.020); no change was observed in the diet-treated group (31.0 ± 10.7%, 33.8 ± 12.4%; p = NS). While OCT demonstrated a significant increase in fibrous cap thickness (140 ± 42 μm, 189 ± 46 μm; p = 0.001), such changes were not observed in the diet-only group (140 ± 35 μm, 142 ± 36 μm; p = NS). Differences in the changes in the percentage lipid volume index (−6.8 ± 8.0% vs. 2.8 ± 9.9%, p = 0.031) and fibrous cap thickness (52 ± 32 μm vs. 2 ± 22 μm, p < 0.001) over time between the pitavastatin and diet groups were highly significant. Conclusions Statin treatment induces favorable plaque morphologic changes with an increase in fibrous cap thickness, and decreases in both percentage plaque and lipid volume indexes.</description><subject>Aged</subject><subject>Cardiovascular</subject><subject>Coronary Angiography</subject><subject>Coronary Artery Disease - diagnostic imaging</subject><subject>Coronary Artery Disease - drug therapy</subject><subject>Coronary Artery Disease - pathology</subject><subject>Coronary Vessels - diagnostic imaging</subject><subject>Female</subject><subject>Humans</subject><subject>Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use</subject><subject>Male</subject><subject>Plaque, Atherosclerotic - diagnostic imaging</subject><subject>Plaque, Atherosclerotic - drug therapy</subject><subject>Plaque, Atherosclerotic - pathology</subject><subject>Quinolines - therapeutic use</subject><subject>Tomography, Optical Coherence</subject><subject>Ultrasonography, Interventional</subject><issn>1936-878X</issn><issn>1876-7591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kc1q3DAUhUVpadK0L9BF0a6beHIl25K1KaRDmw4EUphJ6U7I8lVixz9TSRPwru_QN-yTVGaSwgEJ7rkHzncJec9gxYCJi27V2eFuxYGxVRIw_oKcskqKTJaKvUx_lYusktXPE_ImhA5AgCjka3LCeV5AxfNTMm-GvbGRTo5uo4ntSHf36M1-ptNIv_fm1wHp-t745EHfhtjaQE2glyFgUkPrmW7TwPT0Zr07p1fezMGaHqkZG7oZI955E5Pvs7EPaRBTyt_ffzY_brdvyStn-oDvnt4zcvv1y279Lbu-udqsL68zWwgZMydc6RgreQlgK8bRVi53tckbyRRIrAFMA6qGCqzhEl1VcoUNukIKqRqVn5GPx9y9n1KbEPXQBot9b0acDkErzgulpOTJyY9O66cQPDq99-1g_KwZ6IW47vRCXC_EdVIinpY-PMUf6gGb_yvPiJPh09GAqeRji17bvh3bBOkBZwzddPBj6q-ZDlyD3i5HW27GGEClmMj_AeLGlBc</recordid><startdate>20120201</startdate><enddate>20120201</enddate><creator>Hattori, Kousuke, MD</creator><creator>Ozaki, Yukio, MD</creator><creator>Ismail, Tevfik F., MBBS</creator><creator>Okumura, Masanori, MD</creator><creator>Naruse, Hiroyuki, MD</creator><creator>Kan, Shino, MD</creator><creator>Ishikawa, Makoto, MD</creator><creator>Kawai, Tomoko, MD</creator><creator>Ohta, Masaya, MD</creator><creator>Kawai, Hideki, MD</creator><creator>Hashimoto, Tousei, MD</creator><creator>Takagi, Yasushi, MD</creator><creator>Ishii, Junichi, MD</creator><creator>Serruys, Patrick W., MD</creator><creator>Narula, Jagat, MD</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120201</creationdate><title>Impact of Statin Therapy on Plaque Characteristics as Assessed by Serial OCT, Grayscale and Integrated Backscatter–IVUS</title><author>Hattori, Kousuke, MD ; Ozaki, Yukio, MD ; Ismail, Tevfik F., MBBS ; Okumura, Masanori, MD ; Naruse, Hiroyuki, MD ; Kan, Shino, MD ; Ishikawa, Makoto, MD ; Kawai, Tomoko, MD ; Ohta, Masaya, MD ; Kawai, Hideki, MD ; Hashimoto, Tousei, MD ; Takagi, Yasushi, MD ; Ishii, Junichi, MD ; Serruys, Patrick W., MD ; Narula, Jagat, MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c467t-f6f5f1152500c812ec8f3fba3d71907eb00ad09b080ca27ef8529edef47679d93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Aged</topic><topic>Cardiovascular</topic><topic>Coronary Angiography</topic><topic>Coronary Artery Disease - diagnostic imaging</topic><topic>Coronary Artery Disease - drug therapy</topic><topic>Coronary Artery Disease - pathology</topic><topic>Coronary Vessels - diagnostic imaging</topic><topic>Female</topic><topic>Humans</topic><topic>Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use</topic><topic>Male</topic><topic>Plaque, Atherosclerotic - diagnostic imaging</topic><topic>Plaque, Atherosclerotic - drug therapy</topic><topic>Plaque, Atherosclerotic - pathology</topic><topic>Quinolines - therapeutic use</topic><topic>Tomography, Optical Coherence</topic><topic>Ultrasonography, Interventional</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hattori, Kousuke, MD</creatorcontrib><creatorcontrib>Ozaki, Yukio, MD</creatorcontrib><creatorcontrib>Ismail, Tevfik F., MBBS</creatorcontrib><creatorcontrib>Okumura, Masanori, MD</creatorcontrib><creatorcontrib>Naruse, Hiroyuki, MD</creatorcontrib><creatorcontrib>Kan, Shino, MD</creatorcontrib><creatorcontrib>Ishikawa, Makoto, MD</creatorcontrib><creatorcontrib>Kawai, Tomoko, MD</creatorcontrib><creatorcontrib>Ohta, Masaya, MD</creatorcontrib><creatorcontrib>Kawai, Hideki, MD</creatorcontrib><creatorcontrib>Hashimoto, Tousei, MD</creatorcontrib><creatorcontrib>Takagi, Yasushi, MD</creatorcontrib><creatorcontrib>Ishii, Junichi, MD</creatorcontrib><creatorcontrib>Serruys, Patrick W., MD</creatorcontrib><creatorcontrib>Narula, Jagat, MD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>JACC. Cardiovascular imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hattori, Kousuke, MD</au><au>Ozaki, Yukio, MD</au><au>Ismail, Tevfik F., MBBS</au><au>Okumura, Masanori, MD</au><au>Naruse, Hiroyuki, MD</au><au>Kan, Shino, MD</au><au>Ishikawa, Makoto, MD</au><au>Kawai, Tomoko, MD</au><au>Ohta, Masaya, MD</au><au>Kawai, Hideki, MD</au><au>Hashimoto, Tousei, MD</au><au>Takagi, Yasushi, MD</au><au>Ishii, Junichi, MD</au><au>Serruys, Patrick W., MD</au><au>Narula, Jagat, MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of Statin Therapy on Plaque Characteristics as Assessed by Serial OCT, Grayscale and Integrated Backscatter–IVUS</atitle><jtitle>JACC. Cardiovascular imaging</jtitle><addtitle>JACC Cardiovasc Imaging</addtitle><date>2012-02-01</date><risdate>2012</risdate><volume>5</volume><issue>2</issue><spage>169</spage><epage>177</epage><pages>169-177</pages><issn>1936-878X</issn><eissn>1876-7591</eissn><abstract>Objectives The purpose of this study was to evaluate the effect of statin treatment on coronary plaque composition and morphology by optical coherence tomography (OCT), grayscale and integrated backscatter (IB) intravascular ultrasound (IVUS) imaging. Background Although previous studies have demonstrated that statins substantially improve cardiac mortality, their precise effect on the lipid content and fibrous cap thickness of atherosclerotic coronary lesions is less clear. While IVUS lacks the spatial resolution to accurately assess fibrous cap thickness, OCT lacks the penetration of IVUS. We used a combination of OCT, grayscale and IB-IVUS to comprehensively assess the impact of pitavastatin on plaque characteristics. Methods Prospective serial OCT, grayscale and IB-IVUS of nontarget lesions was performed in 42 stable angina patients undergoing elective coronary intervention. Of these, 26 received 4 mg pitavastatin after the baseline study; 16 subjects who refused statin treatment were followed with dietary modification alone. Follow-up imaging was performed after a median interval of 9 months. Results Grayscale IVUS revealed that in the statin-treated patients, percent plaque volume index was significantly reduced over time (48.5 ± 10.4%, 42.0 ± 11.1%; p = 0.033), whereas no change was observed in the diet-only patients (48.7 ± 10.4%, 50.4 ± 11.8%; p = NS). IB-IVUS identified significant reductions in the percentage lipid volume index over time (34.9 ± 12.2%, 28.2 ± 7.5%; p = 0.020); no change was observed in the diet-treated group (31.0 ± 10.7%, 33.8 ± 12.4%; p = NS). While OCT demonstrated a significant increase in fibrous cap thickness (140 ± 42 μm, 189 ± 46 μm; p = 0.001), such changes were not observed in the diet-only group (140 ± 35 μm, 142 ± 36 μm; p = NS). Differences in the changes in the percentage lipid volume index (−6.8 ± 8.0% vs. 2.8 ± 9.9%, p = 0.031) and fibrous cap thickness (52 ± 32 μm vs. 2 ± 22 μm, p < 0.001) over time between the pitavastatin and diet groups were highly significant. Conclusions Statin treatment induces favorable plaque morphologic changes with an increase in fibrous cap thickness, and decreases in both percentage plaque and lipid volume indexes.</abstract><cop>United States</cop><pmid>22340823</pmid><doi>10.1016/j.jcmg.2011.11.012</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1936-878X |
| ispartof | JACC. Cardiovascular imaging, 2012-02, Vol.5 (2), p.169-177 |
| issn | 1936-878X 1876-7591 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_922499772 |
| source | MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Aged Cardiovascular Coronary Angiography Coronary Artery Disease - diagnostic imaging Coronary Artery Disease - drug therapy Coronary Artery Disease - pathology Coronary Vessels - diagnostic imaging Female Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use Male Plaque, Atherosclerotic - diagnostic imaging Plaque, Atherosclerotic - drug therapy Plaque, Atherosclerotic - pathology Quinolines - therapeutic use Tomography, Optical Coherence Ultrasonography, Interventional |
| title | Impact of Statin Therapy on Plaque Characteristics as Assessed by Serial OCT, Grayscale and Integrated Backscatter–IVUS |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-03T09%3A13%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Impact%20of%20Statin%20Therapy%20on%20Plaque%20Characteristics%20as%20Assessed%20by%20Serial%20OCT,%20Grayscale%20and%20Integrated%20Backscatter%E2%80%93IVUS&rft.jtitle=JACC.%20Cardiovascular%20imaging&rft.au=Hattori,%20Kousuke,%20MD&rft.date=2012-02-01&rft.volume=5&rft.issue=2&rft.spage=169&rft.epage=177&rft.pages=169-177&rft.issn=1936-878X&rft.eissn=1876-7591&rft_id=info:doi/10.1016/j.jcmg.2011.11.012&rft_dat=%3Cproquest_cross%3E922499772%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=922499772&rft_id=info:pmid/22340823&rft_els_id=1_s2_0_S1936878X11008916&rfr_iscdi=true |