Elevated and sustained expression of the transcription factors Egr1 and Egr2 controls NKT lineage differentiation in response to TCR signaling
The mechanisms by which TCR signaling 'instructs' thymic lineages remain unclear. Bendelac and colleagues show that the TCR-induced transcription factor Egr2 specifies the early and late stages of differentiation into the natural killer T cell lineage. Interactions driven by the T cell ant...
Gespeichert in:
| Veröffentlicht in: | Nature immunology 2012-03, Vol.13 (3), p.264-271 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 271 |
|---|---|
| container_issue | 3 |
| container_start_page | 264 |
| container_title | Nature immunology |
| container_volume | 13 |
| creator | Seiler, Michael P Mathew, Rebecca Liszewski, Megan K Spooner, Chauncey J Barr, Kenneth Meng, Fanyong Singh, Harinder Bendelac, Albert |
| description | The mechanisms by which TCR signaling 'instructs' thymic lineages remain unclear. Bendelac and colleagues show that the TCR-induced transcription factor Egr2 specifies the early and late stages of differentiation into the natural killer T cell lineage.
Interactions driven by the T cell antigen receptor (TCR) determine the lineage fate of CD4
+
CD8
+
thymocytes, but the molecular mechanisms that induce the lineage-determining transcription factors are unknown. Here we found that TCR-induced transcription factors Egr2 and Egr1 had higher and more-prolonged expression in precursors of the natural killer T (NKT) than in cells of conventional lineages. Chromatin immunoprecipitation followed by deep sequencing showed that Egr2 directly bound and activated the promoter of
Zbtb16
, which encodes the NKT lineage–specific transcription factor PLZF. Egr2 also bound the promoter of
Il2rb
, which encodes the interleukin 2 (IL-2) receptor β-chain, and controlled the responsiveness to IL-15, which signals the terminal differentiation of the NKT lineage. Thus, we propose that persistent higher expression of Egr2 specifies the early and late stages of NKT lineage differentiation, providing a discriminating mechanism that enables TCR signaling to 'instruct' a thymic lineage. |
| doi_str_mv | 10.1038/ni.2230 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_922498541</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A281460487</galeid><sourcerecordid>A281460487</sourcerecordid><originalsourceid>FETCH-LOGICAL-c574t-85a8b46a9e31882b2f989374256f55e3f6c9acf8755d0c8a61d884de4a2608b93</originalsourceid><addsrcrecordid>eNp9ksFu1DAQhiMEoqUg3gBZ4kA57GI7jmMfq9UWKiqQynKOvMk4uMraweOg8hI8M05ZWhYh5IPH4-__NTN2UTxndMloqd54t-S8pA-KY1ZxveCayYd3MVVHxRPEa0qZqKV4XBzNrJSaHhc_1gN8Mwk6YnxHcMJknM8nuBkjILrgSbAkfQGSovHYRjemOWlNm0JEsu4ju5XmgJM2-BTDgOTD-w0ZspHpgXTOWojgkzO3UudJth6Dx2wayGZ1RdD13mS-f1o8smZAeLbfT4rP5-vN6t3i8uPbi9XZ5aKtapEWqjJqK6TRUDKl-JZbrXRZC15JW1VQWtlq01pVV1VHW2Uk65QSHQjDJVVbXZ4Ur375jjF8nQBTs3PYwjAYD2HCRnMutKoEy-Tpf0lGuaJMZ0FGX_6FXocp5sZmqhS5Qlnqe6o3AzTO25An286mzRlXTEgqVJ2p5T-ovDrYuTxmsC7nDwSvDwTzU8BN6s2E2Fx8ujpk9923MSBGsM0Y3c7E77nOuVTVeNfMfySTL_YtTdsddHfc7w90Px7MV76H-GfPh14_AeqK0EE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1034893639</pqid></control><display><type>article</type><title>Elevated and sustained expression of the transcription factors Egr1 and Egr2 controls NKT lineage differentiation in response to TCR signaling</title><source>MEDLINE</source><source>Nature Journals Online</source><source>SpringerLink Journals - AutoHoldings</source><creator>Seiler, Michael P ; Mathew, Rebecca ; Liszewski, Megan K ; Spooner, Chauncey J ; Barr, Kenneth ; Meng, Fanyong ; Singh, Harinder ; Bendelac, Albert</creator><creatorcontrib>Seiler, Michael P ; Mathew, Rebecca ; Liszewski, Megan K ; Spooner, Chauncey J ; Barr, Kenneth ; Meng, Fanyong ; Singh, Harinder ; Bendelac, Albert</creatorcontrib><description>The mechanisms by which TCR signaling 'instructs' thymic lineages remain unclear. Bendelac and colleagues show that the TCR-induced transcription factor Egr2 specifies the early and late stages of differentiation into the natural killer T cell lineage.
Interactions driven by the T cell antigen receptor (TCR) determine the lineage fate of CD4
+
CD8
+
thymocytes, but the molecular mechanisms that induce the lineage-determining transcription factors are unknown. Here we found that TCR-induced transcription factors Egr2 and Egr1 had higher and more-prolonged expression in precursors of the natural killer T (NKT) than in cells of conventional lineages. Chromatin immunoprecipitation followed by deep sequencing showed that Egr2 directly bound and activated the promoter of
Zbtb16
, which encodes the NKT lineage–specific transcription factor PLZF. Egr2 also bound the promoter of
Il2rb
, which encodes the interleukin 2 (IL-2) receptor β-chain, and controlled the responsiveness to IL-15, which signals the terminal differentiation of the NKT lineage. Thus, we propose that persistent higher expression of Egr2 specifies the early and late stages of NKT lineage differentiation, providing a discriminating mechanism that enables TCR signaling to 'instruct' a thymic lineage.</description><identifier>ISSN: 1529-2908</identifier><identifier>EISSN: 1529-2916</identifier><identifier>DOI: 10.1038/ni.2230</identifier><identifier>PMID: 22306690</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>631/136/1660/1986 ; 631/250/1619/554/1775 ; 631/250/1619/554/383 ; 631/250/248 ; Animals ; Antigen receptors, T cell ; Biomedical and Life Sciences ; Biomedicine ; Cell Differentiation ; Cell Lineage ; Early Growth Response Protein 1 - genetics ; Early Growth Response Protein 1 - immunology ; Early Growth Response Protein 1 - metabolism ; Early Growth Response Protein 2 - genetics ; Early Growth Response Protein 2 - immunology ; Early Growth Response Protein 2 - metabolism ; Genetic aspects ; Humans ; Immunology ; Infectious Diseases ; Killer cells ; Kruppel-Like Transcription Factors - immunology ; Mice ; Mice, Knockout ; Molecular Sequence Data ; Natural Killer T-Cells - cytology ; Natural Killer T-Cells - immunology ; Natural Killer T-Cells - metabolism ; Physiological aspects ; Promoter Regions, Genetic ; Promyelocytic Leukemia Zinc Finger Protein ; Protein Binding ; Receptors ; Receptors, Antigen, T-Cell - immunology ; Receptors, Antigen, T-Cell - metabolism ; Signal Transduction ; T cells ; Transcription factors</subject><ispartof>Nature immunology, 2012-03, Vol.13 (3), p.264-271</ispartof><rights>Springer Nature America, Inc. 2012</rights><rights>COPYRIGHT 2012 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Mar 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c574t-85a8b46a9e31882b2f989374256f55e3f6c9acf8755d0c8a61d884de4a2608b93</citedby><cites>FETCH-LOGICAL-c574t-85a8b46a9e31882b2f989374256f55e3f6c9acf8755d0c8a61d884de4a2608b93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/ni.2230$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/ni.2230$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22306690$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Seiler, Michael P</creatorcontrib><creatorcontrib>Mathew, Rebecca</creatorcontrib><creatorcontrib>Liszewski, Megan K</creatorcontrib><creatorcontrib>Spooner, Chauncey J</creatorcontrib><creatorcontrib>Barr, Kenneth</creatorcontrib><creatorcontrib>Meng, Fanyong</creatorcontrib><creatorcontrib>Singh, Harinder</creatorcontrib><creatorcontrib>Bendelac, Albert</creatorcontrib><title>Elevated and sustained expression of the transcription factors Egr1 and Egr2 controls NKT lineage differentiation in response to TCR signaling</title><title>Nature immunology</title><addtitle>Nat Immunol</addtitle><addtitle>Nat Immunol</addtitle><description>The mechanisms by which TCR signaling 'instructs' thymic lineages remain unclear. Bendelac and colleagues show that the TCR-induced transcription factor Egr2 specifies the early and late stages of differentiation into the natural killer T cell lineage.
Interactions driven by the T cell antigen receptor (TCR) determine the lineage fate of CD4
+
CD8
+
thymocytes, but the molecular mechanisms that induce the lineage-determining transcription factors are unknown. Here we found that TCR-induced transcription factors Egr2 and Egr1 had higher and more-prolonged expression in precursors of the natural killer T (NKT) than in cells of conventional lineages. Chromatin immunoprecipitation followed by deep sequencing showed that Egr2 directly bound and activated the promoter of
Zbtb16
, which encodes the NKT lineage–specific transcription factor PLZF. Egr2 also bound the promoter of
Il2rb
, which encodes the interleukin 2 (IL-2) receptor β-chain, and controlled the responsiveness to IL-15, which signals the terminal differentiation of the NKT lineage. Thus, we propose that persistent higher expression of Egr2 specifies the early and late stages of NKT lineage differentiation, providing a discriminating mechanism that enables TCR signaling to 'instruct' a thymic lineage.</description><subject>631/136/1660/1986</subject><subject>631/250/1619/554/1775</subject><subject>631/250/1619/554/383</subject><subject>631/250/248</subject><subject>Animals</subject><subject>Antigen receptors, T cell</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Differentiation</subject><subject>Cell Lineage</subject><subject>Early Growth Response Protein 1 - genetics</subject><subject>Early Growth Response Protein 1 - immunology</subject><subject>Early Growth Response Protein 1 - metabolism</subject><subject>Early Growth Response Protein 2 - genetics</subject><subject>Early Growth Response Protein 2 - immunology</subject><subject>Early Growth Response Protein 2 - metabolism</subject><subject>Genetic aspects</subject><subject>Humans</subject><subject>Immunology</subject><subject>Infectious Diseases</subject><subject>Killer cells</subject><subject>Kruppel-Like Transcription Factors - immunology</subject><subject>Mice</subject><subject>Mice, Knockout</subject><subject>Molecular Sequence Data</subject><subject>Natural Killer T-Cells - cytology</subject><subject>Natural Killer T-Cells - immunology</subject><subject>Natural Killer T-Cells - metabolism</subject><subject>Physiological aspects</subject><subject>Promoter Regions, Genetic</subject><subject>Promyelocytic Leukemia Zinc Finger Protein</subject><subject>Protein Binding</subject><subject>Receptors</subject><subject>Receptors, Antigen, T-Cell - immunology</subject><subject>Receptors, Antigen, T-Cell - metabolism</subject><subject>Signal Transduction</subject><subject>T cells</subject><subject>Transcription factors</subject><issn>1529-2908</issn><issn>1529-2916</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9ksFu1DAQhiMEoqUg3gBZ4kA57GI7jmMfq9UWKiqQynKOvMk4uMraweOg8hI8M05ZWhYh5IPH4-__NTN2UTxndMloqd54t-S8pA-KY1ZxveCayYd3MVVHxRPEa0qZqKV4XBzNrJSaHhc_1gN8Mwk6YnxHcMJknM8nuBkjILrgSbAkfQGSovHYRjemOWlNm0JEsu4ju5XmgJM2-BTDgOTD-w0ZspHpgXTOWojgkzO3UudJth6Dx2wayGZ1RdD13mS-f1o8smZAeLbfT4rP5-vN6t3i8uPbi9XZ5aKtapEWqjJqK6TRUDKl-JZbrXRZC15JW1VQWtlq01pVV1VHW2Uk65QSHQjDJVVbXZ4Ur375jjF8nQBTs3PYwjAYD2HCRnMutKoEy-Tpf0lGuaJMZ0FGX_6FXocp5sZmqhS5Qlnqe6o3AzTO25An286mzRlXTEgqVJ2p5T-ovDrYuTxmsC7nDwSvDwTzU8BN6s2E2Fx8ujpk9923MSBGsM0Y3c7E77nOuVTVeNfMfySTL_YtTdsddHfc7w90Px7MV76H-GfPh14_AeqK0EE</recordid><startdate>20120301</startdate><enddate>20120301</enddate><creator>Seiler, Michael P</creator><creator>Mathew, Rebecca</creator><creator>Liszewski, Megan K</creator><creator>Spooner, Chauncey J</creator><creator>Barr, Kenneth</creator><creator>Meng, Fanyong</creator><creator>Singh, Harinder</creator><creator>Bendelac, Albert</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>3V.</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20120301</creationdate><title>Elevated and sustained expression of the transcription factors Egr1 and Egr2 controls NKT lineage differentiation in response to TCR signaling</title><author>Seiler, Michael P ; Mathew, Rebecca ; Liszewski, Megan K ; Spooner, Chauncey J ; Barr, Kenneth ; Meng, Fanyong ; Singh, Harinder ; Bendelac, Albert</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c574t-85a8b46a9e31882b2f989374256f55e3f6c9acf8755d0c8a61d884de4a2608b93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>631/136/1660/1986</topic><topic>631/250/1619/554/1775</topic><topic>631/250/1619/554/383</topic><topic>631/250/248</topic><topic>Animals</topic><topic>Antigen receptors, T cell</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cell Differentiation</topic><topic>Cell Lineage</topic><topic>Early Growth Response Protein 1 - genetics</topic><topic>Early Growth Response Protein 1 - immunology</topic><topic>Early Growth Response Protein 1 - metabolism</topic><topic>Early Growth Response Protein 2 - genetics</topic><topic>Early Growth Response Protein 2 - immunology</topic><topic>Early Growth Response Protein 2 - metabolism</topic><topic>Genetic aspects</topic><topic>Humans</topic><topic>Immunology</topic><topic>Infectious Diseases</topic><topic>Killer cells</topic><topic>Kruppel-Like Transcription Factors - immunology</topic><topic>Mice</topic><topic>Mice, Knockout</topic><topic>Molecular Sequence Data</topic><topic>Natural Killer T-Cells - cytology</topic><topic>Natural Killer T-Cells - immunology</topic><topic>Natural Killer T-Cells - metabolism</topic><topic>Physiological aspects</topic><topic>Promoter Regions, Genetic</topic><topic>Promyelocytic Leukemia Zinc Finger Protein</topic><topic>Protein Binding</topic><topic>Receptors</topic><topic>Receptors, Antigen, T-Cell - immunology</topic><topic>Receptors, Antigen, T-Cell - metabolism</topic><topic>Signal Transduction</topic><topic>T cells</topic><topic>Transcription factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Seiler, Michael P</creatorcontrib><creatorcontrib>Mathew, Rebecca</creatorcontrib><creatorcontrib>Liszewski, Megan K</creatorcontrib><creatorcontrib>Spooner, Chauncey J</creatorcontrib><creatorcontrib>Barr, Kenneth</creatorcontrib><creatorcontrib>Meng, Fanyong</creatorcontrib><creatorcontrib>Singh, Harinder</creatorcontrib><creatorcontrib>Bendelac, Albert</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Nature immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Seiler, Michael P</au><au>Mathew, Rebecca</au><au>Liszewski, Megan K</au><au>Spooner, Chauncey J</au><au>Barr, Kenneth</au><au>Meng, Fanyong</au><au>Singh, Harinder</au><au>Bendelac, Albert</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Elevated and sustained expression of the transcription factors Egr1 and Egr2 controls NKT lineage differentiation in response to TCR signaling</atitle><jtitle>Nature immunology</jtitle><stitle>Nat Immunol</stitle><addtitle>Nat Immunol</addtitle><date>2012-03-01</date><risdate>2012</risdate><volume>13</volume><issue>3</issue><spage>264</spage><epage>271</epage><pages>264-271</pages><issn>1529-2908</issn><eissn>1529-2916</eissn><abstract>The mechanisms by which TCR signaling 'instructs' thymic lineages remain unclear. Bendelac and colleagues show that the TCR-induced transcription factor Egr2 specifies the early and late stages of differentiation into the natural killer T cell lineage.
Interactions driven by the T cell antigen receptor (TCR) determine the lineage fate of CD4
+
CD8
+
thymocytes, but the molecular mechanisms that induce the lineage-determining transcription factors are unknown. Here we found that TCR-induced transcription factors Egr2 and Egr1 had higher and more-prolonged expression in precursors of the natural killer T (NKT) than in cells of conventional lineages. Chromatin immunoprecipitation followed by deep sequencing showed that Egr2 directly bound and activated the promoter of
Zbtb16
, which encodes the NKT lineage–specific transcription factor PLZF. Egr2 also bound the promoter of
Il2rb
, which encodes the interleukin 2 (IL-2) receptor β-chain, and controlled the responsiveness to IL-15, which signals the terminal differentiation of the NKT lineage. Thus, we propose that persistent higher expression of Egr2 specifies the early and late stages of NKT lineage differentiation, providing a discriminating mechanism that enables TCR signaling to 'instruct' a thymic lineage.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>22306690</pmid><doi>10.1038/ni.2230</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1529-2908 |
| ispartof | Nature immunology, 2012-03, Vol.13 (3), p.264-271 |
| issn | 1529-2908 1529-2916 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_922498541 |
| source | MEDLINE; Nature Journals Online; SpringerLink Journals - AutoHoldings |
| subjects | 631/136/1660/1986 631/250/1619/554/1775 631/250/1619/554/383 631/250/248 Animals Antigen receptors, T cell Biomedical and Life Sciences Biomedicine Cell Differentiation Cell Lineage Early Growth Response Protein 1 - genetics Early Growth Response Protein 1 - immunology Early Growth Response Protein 1 - metabolism Early Growth Response Protein 2 - genetics Early Growth Response Protein 2 - immunology Early Growth Response Protein 2 - metabolism Genetic aspects Humans Immunology Infectious Diseases Killer cells Kruppel-Like Transcription Factors - immunology Mice Mice, Knockout Molecular Sequence Data Natural Killer T-Cells - cytology Natural Killer T-Cells - immunology Natural Killer T-Cells - metabolism Physiological aspects Promoter Regions, Genetic Promyelocytic Leukemia Zinc Finger Protein Protein Binding Receptors Receptors, Antigen, T-Cell - immunology Receptors, Antigen, T-Cell - metabolism Signal Transduction T cells Transcription factors |
| title | Elevated and sustained expression of the transcription factors Egr1 and Egr2 controls NKT lineage differentiation in response to TCR signaling |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T08%3A34%3A44IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Elevated%20and%20sustained%20expression%20of%20the%20transcription%20factors%20Egr1%20and%20Egr2%20controls%20NKT%20lineage%20differentiation%20in%20response%20to%20TCR%20signaling&rft.jtitle=Nature%20immunology&rft.au=Seiler,%20Michael%20P&rft.date=2012-03-01&rft.volume=13&rft.issue=3&rft.spage=264&rft.epage=271&rft.pages=264-271&rft.issn=1529-2908&rft.eissn=1529-2916&rft_id=info:doi/10.1038/ni.2230&rft_dat=%3Cgale_proqu%3EA281460487%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1034893639&rft_id=info:pmid/22306690&rft_galeid=A281460487&rfr_iscdi=true |