Prognostic significance of using solid versus whole tumor size on high-resolution computed tomography for predicting pathologic malignant grade of tumors in clinical stage IA lung adenocarcinoma: A multicenter study
Objectives The present multicenter study compared the usefulness of the solid tumor size with that of the whole tumor size on preoperative high-resolution computed tomography for predicting pathologic high-grade malignancy (positive lymphatic, vascular, or pleural invasion) and the prognosis of clin...
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| creator | Tsutani, Yasuhiro, MD, PhD Miyata, Yoshihiro, MD, PhD Nakayama, Haruhiko, MD, PhD Okumura, Sakae, MD, PhD Adachi, Shuji, MD, PhD Yoshimura, Masahiro, MD, PhD Okada, Morihito, MD, PhD |
| description | Objectives The present multicenter study compared the usefulness of the solid tumor size with that of the whole tumor size on preoperative high-resolution computed tomography for predicting pathologic high-grade malignancy (positive lymphatic, vascular, or pleural invasion) and the prognosis of clinical stage IA lung adenocarcinoma. Methods We performed high-resolution computed tomography and F-18 fluorodeoxyglucose-positron emission tomography/computed tomography before curative surgical resection in 502 patients with clinical stage IA lung adenocarcinoma. The revised maximum standardized uptake values on F-18 fluorodeoxyglucose-positron emission tomography/computed tomography were used to correct interinstitutional discrepancies. The whole and solid tumor sizes on high-resolution computed tomography were then analyzed in relation to surgical results. Results The mean whole and solid tumor size was 1.97 ± 0.59 cm and 1.20 ± 0.88 cm, respectively. The receiver operating characteristics area under the curve for the whole and solid tumor sizes used to identify high-grade malignancy were 0.590 and 0.829, respectively. Multiple logistic regression analyses demonstrated solid tumor size ( P |
| doi_str_mv | 10.1016/j.jtcvs.2011.10.037 |
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Methods We performed high-resolution computed tomography and F-18 fluorodeoxyglucose-positron emission tomography/computed tomography before curative surgical resection in 502 patients with clinical stage IA lung adenocarcinoma. The revised maximum standardized uptake values on F-18 fluorodeoxyglucose-positron emission tomography/computed tomography were used to correct interinstitutional discrepancies. The whole and solid tumor sizes on high-resolution computed tomography were then analyzed in relation to surgical results. Results The mean whole and solid tumor size was 1.97 ± 0.59 cm and 1.20 ± 0.88 cm, respectively. The receiver operating characteristics area under the curve for the whole and solid tumor sizes used to identify high-grade malignancy were 0.590 and 0.829, respectively. Multiple logistic regression analyses demonstrated solid tumor size ( P < .001) and maximum standardized uptake values of the tumor ( P < .001) as independent variables for the prediction of high-grade malignancy. Multivariate Cox analysis of disease-free survival demonstrated the former (hazard ratio, 2.30; 95% confidence interval, 1.46-3.63; P < .001) and latter (hazard ratio, 1.08; 95% confidence interval, 1.00-1.17; P = .05) as independent prognostic factors. Conclusions The solid tumor size on high-resolution computed tomography and maximum standardized uptake values on positron emission tomography/computed tomography have greater predictive value for high-grade malignancy and prognosis in clinical stage IA lung adenocarcinoma than that of whole tumor size.</description><identifier>ISSN: 0022-5223</identifier><identifier>EISSN: 1097-685X</identifier><identifier>DOI: 10.1016/j.jtcvs.2011.10.037</identifier><identifier>PMID: 22104678</identifier><identifier>CODEN: JTCSAQ</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Adenocarcinoma - diagnostic imaging ; Adenocarcinoma - mortality ; Adenocarcinoma - pathology ; Adenocarcinoma of Lung ; Aged ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Cardiology. Vascular system ; Cardiothoracic Surgery ; Disease-Free Survival ; Female ; Fluorodeoxyglucose F18 ; Humans ; Japan ; Kaplan-Meier Estimate ; Logistic Models ; Lung Neoplasms - diagnostic imaging ; Lung Neoplasms - mortality ; Lung Neoplasms - pathology ; Male ; Medical sciences ; Middle Aged ; Multimodal Imaging ; Multiple tumors. Solid tumors. Tumors in childhood (general aspects) ; Neoplasm Grading ; Neoplasm Staging ; Pneumology ; Positron-Emission Tomography ; Predictive Value of Tests ; Prognosis ; Proportional Hazards Models ; Radiopharmaceuticals ; Risk Assessment ; Risk Factors ; Survival Rate ; Time Factors ; Tomography, X-Ray Computed ; Tumor Burden ; Tumors ; Tumors of the respiratory system and mediastinum</subject><ispartof>The Journal of thoracic and cardiovascular surgery, 2012-03, Vol.143 (3), p.607-612</ispartof><rights>The American Association for Thoracic Surgery</rights><rights>2012 The American Association for Thoracic Surgery</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2012 The American Association for Thoracic Surgery. Published by Mosby, Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c554t-1a2703e3ea8d52b28e2cdd5971a58968446339bf6242acbdd23b298b10fa17573</citedby><cites>FETCH-LOGICAL-c554t-1a2703e3ea8d52b28e2cdd5971a58968446339bf6242acbdd23b298b10fa17573</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jtcvs.2011.10.037$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25610611$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22104678$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tsutani, Yasuhiro, MD, PhD</creatorcontrib><creatorcontrib>Miyata, Yoshihiro, MD, PhD</creatorcontrib><creatorcontrib>Nakayama, Haruhiko, MD, PhD</creatorcontrib><creatorcontrib>Okumura, Sakae, MD, PhD</creatorcontrib><creatorcontrib>Adachi, Shuji, MD, PhD</creatorcontrib><creatorcontrib>Yoshimura, Masahiro, MD, PhD</creatorcontrib><creatorcontrib>Okada, Morihito, MD, PhD</creatorcontrib><title>Prognostic significance of using solid versus whole tumor size on high-resolution computed tomography for predicting pathologic malignant grade of tumors in clinical stage IA lung adenocarcinoma: A multicenter study</title><title>The Journal of thoracic and cardiovascular surgery</title><addtitle>J Thorac Cardiovasc Surg</addtitle><description>Objectives The present multicenter study compared the usefulness of the solid tumor size with that of the whole tumor size on preoperative high-resolution computed tomography for predicting pathologic high-grade malignancy (positive lymphatic, vascular, or pleural invasion) and the prognosis of clinical stage IA lung adenocarcinoma. Methods We performed high-resolution computed tomography and F-18 fluorodeoxyglucose-positron emission tomography/computed tomography before curative surgical resection in 502 patients with clinical stage IA lung adenocarcinoma. The revised maximum standardized uptake values on F-18 fluorodeoxyglucose-positron emission tomography/computed tomography were used to correct interinstitutional discrepancies. The whole and solid tumor sizes on high-resolution computed tomography were then analyzed in relation to surgical results. Results The mean whole and solid tumor size was 1.97 ± 0.59 cm and 1.20 ± 0.88 cm, respectively. The receiver operating characteristics area under the curve for the whole and solid tumor sizes used to identify high-grade malignancy were 0.590 and 0.829, respectively. Multiple logistic regression analyses demonstrated solid tumor size ( P < .001) and maximum standardized uptake values of the tumor ( P < .001) as independent variables for the prediction of high-grade malignancy. Multivariate Cox analysis of disease-free survival demonstrated the former (hazard ratio, 2.30; 95% confidence interval, 1.46-3.63; P < .001) and latter (hazard ratio, 1.08; 95% confidence interval, 1.00-1.17; P = .05) as independent prognostic factors. Conclusions The solid tumor size on high-resolution computed tomography and maximum standardized uptake values on positron emission tomography/computed tomography have greater predictive value for high-grade malignancy and prognosis in clinical stage IA lung adenocarcinoma than that of whole tumor size.</description><subject>Adenocarcinoma - diagnostic imaging</subject><subject>Adenocarcinoma - mortality</subject><subject>Adenocarcinoma - pathology</subject><subject>Adenocarcinoma of Lung</subject><subject>Aged</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Cardiology. Vascular system</subject><subject>Cardiothoracic Surgery</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Fluorodeoxyglucose F18</subject><subject>Humans</subject><subject>Japan</subject><subject>Kaplan-Meier Estimate</subject><subject>Logistic Models</subject><subject>Lung Neoplasms - diagnostic imaging</subject><subject>Lung Neoplasms - mortality</subject><subject>Lung Neoplasms - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multimodal Imaging</subject><subject>Multiple tumors. Solid tumors. Tumors in childhood (general aspects)</subject><subject>Neoplasm Grading</subject><subject>Neoplasm Staging</subject><subject>Pneumology</subject><subject>Positron-Emission Tomography</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>Radiopharmaceuticals</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Survival Rate</subject><subject>Time Factors</subject><subject>Tomography, X-Ray Computed</subject><subject>Tumor Burden</subject><subject>Tumors</subject><subject>Tumors of the respiratory system and mediastinum</subject><issn>0022-5223</issn><issn>1097-685X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFktuKFDEQhhtR3HH1CQTJjXjVY5I-CwrD4mFhQUEF70I6qe7J2N3pzWFkfFFfx-qZWQVvvAoJX_31p_5KkqeMrhll5cvdehfU3q85ZQxf1jSr7iUrRpsqLevi2_1kRSnnacF5dpE88n5HKa0oax4mF5wzmpdVvUp-fXK2n6wPRhFv-sl0RslJAbEdid5MPfF2MJrswfnoyY-tHYCEOFqH-E_EJrI1_TZ1gFwMBu_KjnMMoEmwo-2dnLcH0iE_O9BGhUVzlgGFbI9NRzlgWzkFgqg-9j3Ke2JQajAT-hmID7IHcr0hQ8Ry5CarpFNmsqN8RTZkjAP-AKYA6CtEfXicPOjk4OHJ-bxMvr57--XqQ3rz8f311eYmVUWRh5RJXtEMMpC1LnjLa-BK66KpmCzqpqzzvMyypu1KnnOpWq151vKmbhntJKuKKrtMXpx0Z2dvI_ggRuMVDIOcwEYvGs7zpsprimR2IpWz3jvoxOzMKN1BMCqWQMVOHAMVS6DLIwaKVc_O-rEdQf-puUsQgednQHqcVOcwPeP_ckXJaMkYcq9PHOA09gac8MoAJq2NAxWEtuY_Rt78U38Xznc4gN_Z6CYctGDCc0HF52X3ltVjqMjQRPYbjBnayw</recordid><startdate>20120301</startdate><enddate>20120301</enddate><creator>Tsutani, Yasuhiro, MD, PhD</creator><creator>Miyata, Yoshihiro, MD, PhD</creator><creator>Nakayama, Haruhiko, MD, PhD</creator><creator>Okumura, Sakae, MD, PhD</creator><creator>Adachi, Shuji, MD, PhD</creator><creator>Yoshimura, Masahiro, MD, PhD</creator><creator>Okada, Morihito, MD, PhD</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120301</creationdate><title>Prognostic significance of using solid versus whole tumor size on high-resolution computed tomography for predicting pathologic malignant grade of tumors in clinical stage IA lung adenocarcinoma: A multicenter study</title><author>Tsutani, Yasuhiro, MD, PhD ; Miyata, Yoshihiro, MD, PhD ; Nakayama, Haruhiko, MD, PhD ; Okumura, Sakae, MD, PhD ; Adachi, Shuji, MD, PhD ; Yoshimura, Masahiro, MD, PhD ; Okada, Morihito, MD, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c554t-1a2703e3ea8d52b28e2cdd5971a58968446339bf6242acbdd23b298b10fa17573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adenocarcinoma - diagnostic imaging</topic><topic>Adenocarcinoma - mortality</topic><topic>Adenocarcinoma - pathology</topic><topic>Adenocarcinoma of Lung</topic><topic>Aged</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Cardiology. Vascular system</topic><topic>Cardiothoracic Surgery</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Fluorodeoxyglucose F18</topic><topic>Humans</topic><topic>Japan</topic><topic>Kaplan-Meier Estimate</topic><topic>Logistic Models</topic><topic>Lung Neoplasms - diagnostic imaging</topic><topic>Lung Neoplasms - mortality</topic><topic>Lung Neoplasms - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multimodal Imaging</topic><topic>Multiple tumors. Solid tumors. Tumors in childhood (general aspects)</topic><topic>Neoplasm Grading</topic><topic>Neoplasm Staging</topic><topic>Pneumology</topic><topic>Positron-Emission Tomography</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>Proportional Hazards Models</topic><topic>Radiopharmaceuticals</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Survival Rate</topic><topic>Time Factors</topic><topic>Tomography, X-Ray Computed</topic><topic>Tumor Burden</topic><topic>Tumors</topic><topic>Tumors of the respiratory system and mediastinum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tsutani, Yasuhiro, MD, PhD</creatorcontrib><creatorcontrib>Miyata, Yoshihiro, MD, PhD</creatorcontrib><creatorcontrib>Nakayama, Haruhiko, MD, PhD</creatorcontrib><creatorcontrib>Okumura, Sakae, MD, PhD</creatorcontrib><creatorcontrib>Adachi, Shuji, MD, PhD</creatorcontrib><creatorcontrib>Yoshimura, Masahiro, MD, PhD</creatorcontrib><creatorcontrib>Okada, Morihito, MD, PhD</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of thoracic and cardiovascular surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tsutani, Yasuhiro, MD, PhD</au><au>Miyata, Yoshihiro, MD, PhD</au><au>Nakayama, Haruhiko, MD, PhD</au><au>Okumura, Sakae, MD, PhD</au><au>Adachi, Shuji, MD, PhD</au><au>Yoshimura, Masahiro, MD, PhD</au><au>Okada, Morihito, MD, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic significance of using solid versus whole tumor size on high-resolution computed tomography for predicting pathologic malignant grade of tumors in clinical stage IA lung adenocarcinoma: A multicenter study</atitle><jtitle>The Journal of thoracic and cardiovascular surgery</jtitle><addtitle>J Thorac Cardiovasc Surg</addtitle><date>2012-03-01</date><risdate>2012</risdate><volume>143</volume><issue>3</issue><spage>607</spage><epage>612</epage><pages>607-612</pages><issn>0022-5223</issn><eissn>1097-685X</eissn><coden>JTCSAQ</coden><abstract>Objectives The present multicenter study compared the usefulness of the solid tumor size with that of the whole tumor size on preoperative high-resolution computed tomography for predicting pathologic high-grade malignancy (positive lymphatic, vascular, or pleural invasion) and the prognosis of clinical stage IA lung adenocarcinoma. Methods We performed high-resolution computed tomography and F-18 fluorodeoxyglucose-positron emission tomography/computed tomography before curative surgical resection in 502 patients with clinical stage IA lung adenocarcinoma. The revised maximum standardized uptake values on F-18 fluorodeoxyglucose-positron emission tomography/computed tomography were used to correct interinstitutional discrepancies. The whole and solid tumor sizes on high-resolution computed tomography were then analyzed in relation to surgical results. Results The mean whole and solid tumor size was 1.97 ± 0.59 cm and 1.20 ± 0.88 cm, respectively. The receiver operating characteristics area under the curve for the whole and solid tumor sizes used to identify high-grade malignancy were 0.590 and 0.829, respectively. Multiple logistic regression analyses demonstrated solid tumor size ( P < .001) and maximum standardized uptake values of the tumor ( P < .001) as independent variables for the prediction of high-grade malignancy. Multivariate Cox analysis of disease-free survival demonstrated the former (hazard ratio, 2.30; 95% confidence interval, 1.46-3.63; P < .001) and latter (hazard ratio, 1.08; 95% confidence interval, 1.00-1.17; P = .05) as independent prognostic factors. Conclusions The solid tumor size on high-resolution computed tomography and maximum standardized uptake values on positron emission tomography/computed tomography have greater predictive value for high-grade malignancy and prognosis in clinical stage IA lung adenocarcinoma than that of whole tumor size.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>22104678</pmid><doi>10.1016/j.jtcvs.2011.10.037</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adenocarcinoma - diagnostic imaging Adenocarcinoma - mortality Adenocarcinoma - pathology Adenocarcinoma of Lung Aged Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Cardiology. Vascular system Cardiothoracic Surgery Disease-Free Survival Female Fluorodeoxyglucose F18 Humans Japan Kaplan-Meier Estimate Logistic Models Lung Neoplasms - diagnostic imaging Lung Neoplasms - mortality Lung Neoplasms - pathology Male Medical sciences Middle Aged Multimodal Imaging Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Neoplasm Grading Neoplasm Staging Pneumology Positron-Emission Tomography Predictive Value of Tests Prognosis Proportional Hazards Models Radiopharmaceuticals Risk Assessment Risk Factors Survival Rate Time Factors Tomography, X-Ray Computed Tumor Burden Tumors Tumors of the respiratory system and mediastinum |
| title | Prognostic significance of using solid versus whole tumor size on high-resolution computed tomography for predicting pathologic malignant grade of tumors in clinical stage IA lung adenocarcinoma: A multicenter study |
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